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Biomedical subjects

J Mohr

Publications and source records attributed to J Mohr.

At least 73 records · Page 4Linked to original sources
PubMed1980

[Purification and specificity control of labelled antibodies (author's transl)].

A review is given about causes of unspecific binding and the possibility of its prevention. Unspecific binding can be caused by: binding of proteins and glycoproteins on cells or tissues by non-covalent links, undesirable antigen-antibody-reactions, non-immune affinity reactions, changes of the charge of antibodies depending on the labelling procedure. A method for fractionation of labelled antibodies by using precipitation with protamine sulphate is described.

Animals↗
PubMed1979

Familial partial 7q monosomy resulting from segregation of an insertional chromosome rearrangement.

A family with an insertional type of chromosome rearrangement involving chromosomes 7 and 13 is reported. An interstitial deletion of a segment of chromosome 7 (7q32 leads to 34) had been inserted into the long arm of chromosome 13 at breakpoint q32. Segregation of this chromosome rearrangement gave rise to three subjects who were monosomic for the involved segment of chromosome 7. The karyotypes were: 46,XX, or XY,der(7)ins(13;7) (q32;q32q34). All three subjects were mentally retarded and had minor dysmorphic features. The Kidd, Colton, and Kell blood group systems were investigated, but were not informative.

Child↗
PubMed1978

Neonatal and maternal lymphocytes in whole-blood cultures: absence of strong interaction.

The relative growth of neonatal and maternal lymphocytes was studied in PHA-stimulated mixed short-time whole-blood cultures, with particular regard to a possible inhibition of the maternal cells. For comparison, neonatal and maternal cells were grown separately. No uniform inhibition was observed, although there was an average 34% depression of growth of the maternal cells in the mixed cultures.

Female↗
PubMed1977

Colton blood groups: indication of linkage with the Kidd (Jk) system as support for assignment to chromosome 7.

A material of normal Danish families was tested for a number of genetic marker systems and analyzed for linkage. For the Colton-Kidd relationship the lod score was + 2.57. The Kidd system has earlier been tentatively assigned to chromosome 7 (Schokeir et al. 1973). The present data therefore permit a tentative assignment to chromosome 7 of the Colton system as well. The data also suggest that the discovery by Chapelle et al. (1975) of a conjunction of monosomy for chromosome 7 in the bone marrow of certain leukemia patients and absence of Colton antigen from the red cells may now be interpreted as being connected with location on chromosome 7 of the Colton system.

Blood Group Antigens↗
PubMed1977

Affinity chromatography of serum proteins using immobilized lectin from Vicia faba.

When human serum is applied to a column of Sepharose-insolubilized lectin from Vicia faba, some serum proteins are bound which can be eluted by means of 0.1 M glucose solution. These proteins are parts of the immunoglobulins IgA, IgG, IgM, and the alpha2-macroglobulin. These particular types of serum protein are bound specifically, due perhaps to some structural variation in the carbohydrate moieties they contain.

Blood Proteins↗
PubMed1977

Cerebral angiography in acute cerebral infarction.

Cerebral angiography in the acute phase of clinically diagnosed stroke syndromes was evaluated in a prospective study of 104 consecutive patients over an eight month period at the Massachusetts General Hospital to determine the diagnostic yield. Of 68 patients subsequently documented to have retinal or cerebral hemispheric infarction, 63 (92.6%) had angiographic demonstration of occlusive lesions which appeared to correlate with the clinical deficit. These results are discordant with prior angiographic reports, 2,17,18,20 suggesting that delayed carotid artery angiography fails to show occlusive lesions (embolic) which may be shown acutely.

Acute Disease↗
PubMed1976

[Experimental and clinical investigations on the effects of carbon dioxide gas during hysteroscopy (author's transl)].

The acute toxicity, lethal dosage and mechanical effects of carbon dioxide gas were studied in the waking dog by intravenous and intra-arterial insufflation. The threshold dosage for toxicity was 400 ml per minute in the dog. The important factor in the toxicity was not the total volume of carbon dioxide but the volume per unit of time. Metabolic acidosis was responsible for changes in the EKG, the heart rate and the respiratory rate. These findings are discussed in relationship to the usage of carbon dioxide gas for hysteroscopy in the human female. During carbon dioxide gas hysteroscopy blood gas analyses were done in 40 patients. 28 patients had a hysteroscopy under general anaesthesia and 12 patients under local anaesthesia. It was found that the volume of carbon dioxide used for the creation of a pneumometra in hysteroscopy has no side effect. The necessary gas flow is too small for toxic side effects or mechanical side effects such as a gas embolisation.

Acidosis, Respiratory↗
PubMed1976

The Hysteroflator 1000S.

A new electrical apparatus for CO2 hysteroscopy is described. It adds an electric suction pump to the insufflator to fix the cervical cup securely and maintain the seal indefinitely. The apparatus was used in 257 patients without any untoward effects.

Adult↗