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Biomedical subjects

J Modestin

Publications and source records attributed to J Modestin.

72 records · Page 4Linked to original sources
PubMed1976

[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].

Results of investigations concerning the correlation between plasma concentrations and clinical effect of neuroleptics and antidepressives are summarised. In the case of neuroleptics there is in general no relationship between clinical parameters of activity and plasma concentration. For antidepressives there is, in most cases, a correlation between side-effects and plasma concentrations. Whether the therapeutic effect is dependent on the plasma concentration or not, is however open to some doubt. The practical value of plasma concentration estimations during therapy with the above mentioned drugs is therefore limited. Inadequate efficacy and/or poor tolerance can occasionally be explained by estimating plasma concentrations which alone, however, scarcely allow one to make prophecies. In determination of the optimal individual dosage must continue to be an empirical process based on clinical observations and experience.

Amitriptyline↗
PubMed1975

[The problem of masked depression].

The term "masked depression" appears to be increasingly used as a diagnostic label, but underlying the label are a multitude of problems. Questions of definition, diagnosis, nosologic classification and differential diagnosis are discussed in detail.

Acting Out↗
PubMedDate not supplied

Follow-up study on borderline versus nonborderline personality disorders.

Using a semi-structured interview, 18 DSM-III borderline personality disorder (BPD) patients and 17 other (nonborderline) personality disorder (OPD) patients were compared blind 4 1/2 years after their index discharge. Although significantly younger and mostly single, BPD patients did not differ from OPD patients in the degree of overall psychopathology or in the level of psychosocial functioning and adjustment. They do not seem to represent a particularly severe personality disorder group. Those characteristics differentiating BPD patients from affective disorders and schizophrenia may be nonspecific regarding other personality disorder types. As such, more attention should be paid to cases of OPD in the future.

Adult↗
PubMedDate not supplied

Is the diagnosis of hysterical psychosis justified?: Clinical study of hysterical psychosis, reactive/psychogenic psychosis, and schizophrenia.

Using the method of a "blind" retrospective evaluation of clinical charts, 21 female patients with hysterical psychosis were compared with 21 patients diagnosed as suffering from nonhysterical reactive/psychogenic psychosis and 42 patients diagnosed as schizophrenic according to the Ninth Revision of the International Classification of Diseases (ICD-9). All three groups were restricted to first admissions and matched with regard to sex, age, and year of admission. Many significant differences were found between hysterical psychosis and schizophrenia; the only significant differences between hysterical and nonhysterical reactive/psychogenic psychosis were the presence of histrionic personality and the frequent shift in symptomatology in the former. Thus, both disorders seem to be identical.

Adolescent↗
PubMedDate not supplied

Study on suicide in depressed inpatients.

Seventy-five depressed clinical suicides were compared with 50 depressed non-suicide clinical controls, using the method of stepwise logistic regression analysis. A set of the six best discriminating variables was identified, which comprised male sex, suicidal behavior at index admission and during index hospitalization, number of previous psychiatric hospitalizations, broken home and social exits. These factors should be taken into consideration when estimating suicidal danger in all types of depressed inpatients.

Depressive Disorder↗
PubMedDate not supplied

[Psychotherapy of acute suicidality. "The anti-suicide promise" as a method of preventing suicide].

A trustful therapeutic relationship is considered to be the most important suicide-preventing measure. Furthermore, it has frequently been recommended to have the severely suicidal patient promise not to commit suicide within a certain period of time. Using three clinical examples the unreliability of this suicide-preventing method is demonstrated. When the patient can give such a promise responsibly, it probably is no longer necessary. Also, the patient's giving such a promise can negatively influence the development of the therapeutic relationship. A reciprocal contract should be preferred: the patient contacts the therapist whenever he feels to loose control over his suicidal potential whereas the therapist offers his availability to the patient.

Acute Disease↗