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Biomedical subjects

J Mirouze

Publications and source records attributed to J Mirouze.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Blood glucose self-monitoring: visual or automated read-out? Comparative study of 6 methods of blood glucose determination by reactive strips].

Home blood glucose monitoring is becoming increasingly popular in diabetic patients. The purpose of this work was to determine the accuracy of this technique. We have compared plasma glucose obtained in the laboratory and two reagent strips (Dextrostix and Haemoglukotest 20-800). No differences were found among visually-read values and meter-read values using either Dextrometer, Glukometer, Hypocount or Glucochek. Thus, visually-read strips seem to be sufficient for clinical purposes with best results for HGT. The performances of different meters are similar. Nevertheless must patients favoured the use of a meter because of the apparent "objectivity" of the values. Furthermore, meters provide to patients a better involvement in the management of their disease.

Automation↗
PubMed1984

[Acute renal failure and hepatitis induced by clometacin].

Various types of allergic accidents have been reported with clometacin (Duperan), a synthetic analgesic introduced in France in 1971. The most prominent is hepatitis in elderly women, with hyperglobulinemia, eosinophilia, autoantibodies and giant multinucleated hepatocytes. The case presented herein concerns a 73-year-old woman who, on two separate occasions after the ingestion of clometacin at recommended dosages, developed at the same time typical acute hepatitis and non-oliguric acute renal failure. The second episode came soon after the medication was inadvertently reintroduced. Both hepatic and renal involvements were fully reversible. A renal biopsy showed predominant lesions of acute interstitial nephritis and tubulonecrosis. Three possible mechanisms are discussed: 1) sensitivity of the kidney to drugs because of preceding angiosclerosis, 2) impaired regulation of renal blood flow because of clometacin provoked decrease of prostaglandin synthesis, and 3) as in the case of nephrotoxicity due to other medications, allergic mechanisms.

Acute Kidney Injury↗
PubMed1983

[Pseudo-hypercalcemia of erythrocytic origin. Increased passive membrane permeability to potassium].

Pseudo-hyperkaliemia is a biochemical abnormality suspected when the blood level of K is increased, contrasting with the absence of usual symptoms of hyperkaliemia. The diagnosis is confirmed by the discrepancy between K+ blood levels which are normal if measured immediately after the blood sample is drawn, and increased if the blood sample is incubated at room temperature. In our case, the pseudo-hyperkaliemia is due to the passage of K outside the erythrocytes through increased passive membrane permeability to K. In vivo, this increased passive outflow of K seems to be compensated by an increased active inflow of K dependent on the sodium pump. This explains the absence of true hyperkaliemia and clinical symptoms. In vitro, it seems that the sodium pump is no longer able to ensure this increased activity. Therefore, the abnormality becomes overt, mirrored by a delayed increase in kaliemia.

Adult↗
PubMed1983

[Efficaciousness of enteral feeding at continuous low flow in the treatment of anorexia nervosa].

Metabolic studies were performed in 8 of 14 patients with severe anorexia nervosa (AN) before and after nutritional therapy. The decrease of lean body mass, as judged by the low values of the creatinine-height index (CHI), and the normal levels of visceral proteins demonstrate the marasmic pattern of undernutrition in AN. Low 24-hour urinary 3-methylhistidine and urea levels agree with adaptation to malnutrition by decreasing in muscular breakdown. With enteral and oral feeding, weight gain was impressive and CHI reached normal values; 3-methylhistidine increased, reflecting enhancement of myofibrillar protein metabolism. By the end of refeeding, the levels of rapid-turnover proteins (prealbumin, retinol-binding protein) were higher than normal. Thus enteral feeding appears to be an efficient treatment of malnutrition in severe AN.

Adolescent↗
PubMed1983

[Value of continuous registration of blood D-beta-hydroxybutyrate and glucose. Application in a case of acromegaly].

We describe the use of an autoanalyzer II for continuous whole blood D-beta-hydroxybutyrate and glucose monitoring. The former is analyzed by an enzymatic-fluorimetric determination. This method is simple, reliable and sensitive at low cost. It permits to record dynamic patterns of the two major energetic substrates in response to various stimuli, as shown in an acromegalic patient following a glucose load.

3-Hydroxybutyric Acid↗
PubMed1983

[Pseudohyperkalemia of erythrocyte origin. Passive increase of membrane permeability to potassium].

The pseudo-hyperkalemia is a biochemical abnormality suspected when the blood level of K is increased, contrasting with the absence of usual symptoms of hyperkalemia. The diagnosis is confirmed by the discrepancy between K+ blood levels which are normal if measured immediately after the blood sample is drawn, and increased if the blood sample is incubated at the room temperature. In our case, the pseudo-hyperkalemia is due to the passage of K outside the erythrocytes by an increased passive membrane permeability to K. In vivo, this increased passive outflow of K seems to be compensated by an increased active inflow of K dependent of the sodium pump. Therefore is explained, the absence of true hyperkalemia and clinical symptoms. In vitro, it seems that the sodium pump is no longer able to assure this increased activity. Therefore the abnormality appears as a late increase of kalemia.

Adult↗
PubMed1982

[Personalized diet based on the assessment of caloric levels in the treatment of obesity].

The diet with individual evaluation of the "caloric level" consists in a severe hypocaloric diet (400-800 calories) gradually increased by 100-200 calories every 2-3 days in order to find the level at which the weight loss ceases. This level is usually far higher than that of a conventional diet. The final diet is then obtained by decreasing the intake again by 200 to 300 calories. These diets have been studied in hospitalized then ambulatory patients. 429 patients, some of whom have been followed for over six years, have been studied. The results show that, although the initial weight loss is less important than with a conventional diet, the long-term results are satisfactory in 2/3 of the patients. Patients are distributed equally into four groups according to the degree of weight loss: -10 to -15%, -15 to -20%, -20 to -30%, greater than -30%. Maintenance of the weight loss is as good or even better than with a conventional diet, but with a more liberal program.

Adult↗
PubMed1982

[Comparative study of porcine and human regular insulins using an artificial pancreas].

Porcine extracted monocomponent insulins and human semi-synthetic insulins obtained by enzymatic conversion of porcine insulin had exactly the same clinical effectiveness on blood glucose balance when compared with an artificial pancreas during two 48-hour studies 2 or 3 days apart. There was no significant difference between maximum and minimum blood glucose variations, glycaemic falls and Schlichtkrull coefficient. Glycaemia increased and decreased during meals at a slightly slower rate with human insulin than with porcine insulin, but the differences were not significant. With both types of insulin therapy, insulin requirements per gram of ingested carbohydrates were proportionally more important in the morning than during the rest of the day, dans baseline requirements tended to increase during the day.

Animals↗
PubMed1982

[Metabolic adaptation to chronic denutrition in anorexia nervosa. Effects of realimentation. Value of the assay of urinary 3-methylhistidine].

Nutritional studies conducted in 9 patients suffering from anorexia nervosa showed a marasmus-like pattern with predominant depletion of lean body mass rather than of visceral proteins. In addition, adaptation to insufficient food intake led to a decrease in myofibrillar breakdown, as evidenced by low levels of urinary 3-methylhistidine. Low-flow enteral feeding resulted, within a few weeks, in return to normal of plasma proteins (particularly those with short half-life), while a dramatic increase in urinary 3-methylhistidine suggested acceleration of muscle protein turnover under adequate calorie-protein intake.

Adolescent↗