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Biomedical subjects

J Milner

Publications and source records attributed to J Milner.

At least 109 records · Page 6Linked to original sources
PubMed1975

Inequality of the services received by individuals: a suggested index and an illustrative application.

Population groups that are homogeneous with respect to such factors as insurance status, income level, and proximity to sources of care can still exhibit great internal inequality in the amount of care received by individuals. A statistical measure of this inequality is proposed and its application illustrated on employee groups living in two underdoctored areas. Utilization of physician services in these areas was found to be significantly less equal (as well as lower) than in comparable groups who live in areas with higher ratio of physicians to total population.

Adult↗
PubMed1975

Kidney preservation using combinations of Belzer and Collins techniques.

A study was designed to test the advisability of using combined Belzer and Collins preservation in kidney-sharing programs. Dogs were randomly assigned to seven groups and no donor pretreatment was used. In group 1, left kidneys were removed from dogs; were flushed with Collins solution; and were autotransplanted immediately. In groups 2 through 7, dog kidneys were preserved for 24 hr using combined techniques. The percentage of Collins preservation included in each group was increased progressively until, in Group 7, Collins alone was used. Contralateral nephrectomies were performed at the time of autotransplantation. Between 4 and 8 dogs survived in each group, yielding 43 6-week survivors. Sixty-six per cent of group 7 animals and greater than 90% of animals in other groups survived 6 weeks after transplantation. Average creatinine and blood urea nitrogen values on days 3,7, and 42 showed a progressive increase in kidney damage from groups 1 through 7. As the percentage of time the kidneys were subjected to Collins preservation was increased, the quality of kidney preservation decreased in a progressive manner. This study suggests that Belzer and Collins techniques can be combined, but superior preservation was obtained when the majority of preservation was on the Belzer apparatus.

Animals↗
PubMed1970

Prevalence of hemophilia in Ontario, 1966.

Records of admission to general hospitals throughout Ontario over a six-month period, together with an independently existing list of hemophiliacs known to the Canadian Haemophilia Society, furnish the basis for a statistical estimate of the prevalence of hemophilia in 1966. This is set at 1.44 or more per 10,000 males at birth. It is inferred from age-specific data that the prevalence among the general population may be rising beyond its present level of about 1 per 10,000 living males.

Adolescent↗
PubMedDate not supplied

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of p53 protein correlates with this commitment step. I show here that in unstimulated cells, a second form of p53 is synthesized and is restricted to G0.

Animals↗
PubMedDate not supplied

Clonazepam in childhood anxiety disorders.

OBJECTIVE: There is evidence for the efficacy and safety of clonazepam (CZP) in adult anxiety disorders, but no formal studies to substantiate clinical reports of similar benefit in children with anxiety disorders. METHOD: In this double-blind pilot study, 15 children, aged 7 to 13 years, entered a randomly assigned, double-blind crossover trial of 4 weeks of CZP (up to 2 mg/day) and 4 weeks of placebo. RESULTS: Twelve children completed the trial. All but 1 had a diagnosis of separation anxiety disorder, and all but 2 had comorbid diagnoses. Nine children appeared to have moderate to significant clinical improvement, but statistical comparisons on several ratings failed to confirm a trend in favor of CZP. Side effects of drowsiness, irritability, and/or oppositional behavior were notable in 10 children in the CZP phase compared with 5 in the placebo phase. CONCLUSIONS: Clonazepam was believed to have clinical benefit for some children, but this was not confirmed statistically in this small sample. Problematic side effects of drowsiness and disinhibition were common and possibly were due to rapid titration.

Age of Onset↗
PubMedDate not supplied

Nursing staff characteristics related to patient assault.

There is an underlying belief that there is something special about the victims of patient assault, that they possess certain characteristics or behave in a different way from those staff who are not assaulted. Is this a case of blaming the victims, or are there some actual differences between those staff members who are assaulted and those who are not? This study undertook this question. Its specific purpose was to (1) characterize staff victims and compare them to nonassaulted staff and (2) document outcomes on staff who were assaulted. The design included a prospective and retrospective phase. Nursing staff on two acute and four long-term psychiatric units were asked sociodemographic and job-related information at the beginning of the study. The frequency with which each staff member was assaulted was recorded. At the end of 1 year, staff who had been assaulted were compared with staff who had not been assaulted. Any staff members who were assaulated were interviewed to assess the physical and emotional effect of the assault on the victim. Findings indicated no difference between assaulted versus nonassaulted staff on sociodemographic factors, with the exception of marital status. Assessment of job-related factors suggested differences on position in the administrative hierarchy, type of activities involved in direct patient care such as medication administration, and education about handling the aggressive patient. Victim outcomes supported the existing literature. The most frequent site of injury was the head. Staff either did not take leave time or returned to work before they recovered, and many reported emotional stress.

Hospitals, Psychiatric↗