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Biomedical subjects

J Mignot

Publications and source records attributed to J Mignot.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Histomorphometric study of lymphocyte population in thyroid in Graves' disease after treatment (author's transl)].

The degree of lymphocyte infiltration in subtotal thyroidectomy specimens from patients with treated Graves' disease varies greatly from one case to another. A morphometric study, employing standard and immunofluorescent slides was conducted to evaluate possible statistical correlations between clinical and morphological findings. Quantitative lymphoplasmocytic cellularity differences appeared to be related to the course of the disease. Lymphocyte infiltration was greater in patients with long-standing disease and/or relapses.

Fluorescent Antibody Technique↗
PubMed1981

[Histological morphometric methods. I. Semi-automatic methods on graphic tables (author's transl)].

Two kinds of parameters are accessible by histological morphometric methods: --actual quantitative ones (e.g. length, area) --discontinuous ones (e.g. cells, nucleus or mitochondrium counting). Measures were all achieved by manual methods in past. Nowadays, apparatus are existing that can solve semi-automatically histomorphometric problems. These apparatus are variously named digitizer, digitizing table, digitalizing table, graphic table and so on. Two histomorphometric examples are described one concerning breast carcinoma the other myocardial vascularization in rats. They both have been treated on a graphic table. Problems and their solutions are developed.

Animals↗
PubMed1979

[Measurement of the position and intensity of chromosomal denaturation bands by an automatic system].

The band density profile of a marked chromosome was obtained using a photodiode collector combined with a minicalculator, working with an ordinary photographic document. The measurement was carried out over 10 to 20 300-point lines oriented longitudinally along the chromosome. The profile obtained corresponds to the sum of the values of each of these lines. The proposed systems's originality resides in its ability to determine the position and intensity of a band over the entire thickness of the chromosome.

Autoanalysis↗
PubMed1979

[Quantitation of myelofibrosis in blood diseases by electronic image analysis (author's transl)].

Normal and pathologic reticulin networks colored black by silver nitrate can be automatically quantitated by electronic image analysis. By using this technique, different parameters can be obtained, such as the average density, the surface of network meshes, the thickness of the fibers, the complexity of the reticulum, and the heterogeneity of the myelofibrosis distribution. All of these parameters were obtained in 83 osteomedullar biopsies of blood diseases (primary splenomegaly, chronic myeloid leukemia, polycythermia vera, acute leukemia, and aplastic anemia). We have shown that there is no relation between the different parameters obtained and the medullary richness, hematopoietic center, or patient survival. On the other hand, the histomorphometric parameters can be used to distinguish acute leukemia and chronic myeloid leukemia myelofibrosis, while the parameters in primary splenomegaly are shown to be very heterogeneous.

Acute Disease↗
PubMed1979

[Quantitative study of hepatic fibrosis in Hodgkin's disease (author's transl)].

The construction of a prototype apparatus adapted to the constraints of tissue structures has permitted not only the quantification of fibrosis within the liver but also analysis of its distribution. The cumulative histograms thus achieved permit the characterization of the liver in Hodgkin's disease and its differentiation from other forms of hepatic fibrosis.

Biopsy↗
PubMed1977

[Electronic microscopic study of a sacral chordoma. Characterization of various development stages of the tumor cells].

The electron microscopic study of a sacral chordoma, the cells of which contain variable amounts of glycogen, allowed to characterize different stages in the evolution of the tumoral cells. The young cells contain almost no glycogen ; progressively it becomes more abundant and fills up almost the whole cytoplasm. At the end of the evolution glycogen disappears while the cell becomes vacuolated. This suggests that enzymatic lysis of this polysaccharide could be the cause of the vacuolation which finally produces the physaliferous cell. Comparison between the cells of the chordoma and those of the normal notochord shows some morphological similarities in the development of these cells. These different data may be useful for a classification of the various types of chordomas.

Adult↗
PubMed1975

[Bone marrow biopsy in the diagnosis of hematopoietic tuberculosis].

The authors report 6 cases of tuberculosis of the bone marrow, in which the diagnosis was made by biopsy. Three of these cases, included peripheral blood abnormalities, such as pancytopenia, whereas in the three other, nothing special was found on routine blood examination. All the patients, except one who died from intercurrent infection, became cured thanks to anti-tuberculosis treatment. Marrow biopsy thus permits early diagnosis, miliary tuberculosis, even when usual radiological and bacteriological investigations are negative.

Adult↗