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Biomedical subjects

J Michel

Publications and source records attributed to J Michel.

265 records · Page 15Linked to original sources
PubMedDate not supplied

[Generalized congenital fibromatosis. A new case report (author's transl)].

The authors report a new case of generalized congenital fibromatosis in a young white girl who presented at birth a sub-cutaneous frontal localization with osteolytic lesions. At three and a half months of age, a complete auriculo-ventricular block was discovered secondary to a myocardial localization and she died of acute respiratory failure without showing early anormal pulmonary radiological lesions. In reviewing ten cases of this generalized congenital form of the osteolytic lesions encountered, and stress the fact that the discrete radiological pulmonary signs that condition the prognosis. The then discuss the utility of distinguishing diffus and generalized forms of congenital fibromatosis.

Female↗
PubMedDate not supplied

[Research concerning the spontaneous course of 135 cases of Menière's disease. Critical study of operative indications (author's transl)].

135 cases of Ménière's disease were observed for five and a half years. Out of 1120 Ent patients, one suffered from Ménière's disease. Out of 1 000 audiogram, 8 involved cases of Ménière's disease. Of 9 cases of non-traumatic vertigo where a vetsibular origin was suspected, I was Ménière's disease. The morbidity was 75 per million. Hearing was stable in 62% of cases, worsened in 15%, improved in 15% whilst in 8% there was total deafness before the onset of vertigo. Vertigo disappeared in 94% of cases. Bilateral Ménière's disease is associated with a particularly unfavourable course with regard to general condition, since the disease would appear to be the consequence of a more deep-seated organic disorder. These figures are exactly the same as those found after vestibular neurectomy. In 98% of cases surgery is useless and hence dangerous.

Aged↗
PubMedDate not supplied

Combination chemotherapy with cisplatin, etoposide, and vindesine in non-small cell lung carcinoma: a clinical trial of the EORTC lung cancer working party.

A combination of cisplatin (60 mg/m2 on Day 1), etoposide (120 mg/m2 on Days 3, 5, and 7), and vindesine (1.5 mg/m2 on Days 1 and 7), repeated every 3 weeks, was administered to 73 patients with non-small cell bronchogenic carcinoma. After two full courses, the results could be evaluated in 62 patients, 25 (40.3%) of whom responded (five complete responses, 20 partial responses). The median survival for the responding patients (12 months) was significantly superior (P = 0.02) to that of the nonresponding patients. There were three early toxic deaths from sepsis associated with granulocytopenia, and seven patients presented peripheral neuropathy. Although active in non-small cell bronchogenic carcinoma, the combination of cisplatin, etoposide, and vindesine does not appear to be superior to cisplatin-etoposide or cisplatin-vindesine when our previous experience and the results reported from other institutions are considered.

Adult↗
PubMedDate not supplied

[Sound sensations produced by electric stimulation of the structures of the middle ear and the tympanic chord].

Certain facts must be clearly understood before any attempt is made to analyse the sensations produced by electrical stimulation of the structures of the middle ear. Firstly, when the current passes from an electrode to the skin or to any polarised structure whatsoever, the point at which the electrode is applied and the skin behave like the two plates of a condenser microphone. Electrical vibrations are transformed into ordinary acoustic resonances which can travel through air or bone. These acoustic resonances are fairly pure in comparison with electrical vibrations, judged by the standards under investigation. If a continuous polarisation potential, which gives better distribution of the electrical charges, is added, the capacity of the microphone is increased and greater purity obtained. Consequently, the quality of sound heard in this way depends not only on the quality of this electro-physiological microphone but also on the quality of the internal ear. The acoustic effect produced in this way is called an electrophonic effect. Stevens, Jones and Flottorp described this. Therefore an internal ear which has lost the ability to hear high-pitched sound cannot hear them by means of this electrophonic effect any more than it can by ordinary auditory stimulation. Stimulation of the skin of the mastoid and of the external auditory meatus can be sensed by means of this electrophonic effect. Next, sensations recorded by means of direct stimulation of the acoustic nerve (DJOURNO and EYRIES) or by implantation of intra-cochlear electrodes (SIMMONS, DOYLE, MICHELSON) were studied. Sounds heard through stimulation of the structures of the middle ear should be analysed in the light of these findings and bearing in mind that very strong stimulation of the promontory or of the auditory meatus always causes an auditory sensation without frequency awareness due to global stimulation of the acoustic nerve (faciaestations appeared when experiments, the results of which are described, were carried out, although there is a possibility of episode vestibular irritation. These stimulations were in fact always very weak. Our results were analysed in relation to the quality of the internal ear: completely deaf, serious condition, internal ear normal. The impulses were provided by a direct current battery: these were square with a frequency of between 50 and 900 Hertz, a tension of 0 to 8 volts per 1/10 volt. The electrode was bipolar. The experiments were monitored from time to time by oscilloscope. Mention should be made of the technical and psychological precautions to be observed when stimulation of this kind is carried out if results of any value are to be obtained: a relaxed, sensible patient with whom one can communicate easily. Not much can be gathered from a person deaf in both ears. With the ear opened, the posterior part of the tympanum pulled forward, stimulation of the round window always results in production of a sound at a threshold of 0.5 to 2.5 volts.

Acoustic Stimulation↗