We describe the convenient synthesis of thymidine cyclic 3', 5'-phosphorofluoridate 6, which is superior to that previously reported. Our procedure is based on a sequence of reactions utilizing 3 as the key substrate. Similar sequence of reaction leads to the sulfur analogues of 6 the thymidine cyclic 3',5'-phosphorofluoridothioate 7.

Magnetic Resonance Spectroscopy↗

PubMedDate not supplied

[Lipoma of the corpus callosum].

The authors present a case of lipoma of corpus callosum in a 25-years old patient. The results of psychological testing, plain skull X-ray. EEG investigation, images of CT, MRI of the brain and right carotid angiography are presented. The patient refused surgical treatment. His neurological state after discharge from hospital was good.

Carotid Artery, Internal↗

PubMedDate not supplied

The Warsaw Society of the Friends of Sciences (WTPN).

Explore the source record for details and available documents.

History, 18th Century↗

PubMedDate not supplied

[Results of clinical management of patients with very active rheumatoid arthritis. Comparative demonstration of therapy with non-steroid antiphlogistics, gold salts and the immunosuppressive agents proresid and endoxan].

Explore the source record for details and available documents.

Adolescent↗

PubMedDate not supplied

Interference of psychotropic drugs with the injuring action of ethanol on gastric mucosal barrier.

The aim of this study was to establish whether some psychotropic drugs, applied to patients under influence of alcohol, may potentiate its damaging action on gastric mucosal barrier. A sensitive index of such damage is a decline of the potential difference (PD) across the stomach wall. The experiments were carried out on Wistar rats of either sex, anesthetized with urethane-chloralose. The PD values were assayed with an apolarization method. The investigated solutions were administered intragastrically by gavage. Ethanol at a concentration of 40% v/v depressed PD by 39%. The investigated psychotropic drugs did not change PD by themselves but given in combination with ethanol caused significant decline of PD: diazepam (0.4 mg/kg) by 58%, chlorpromazine (6.7 mg/kg) by 59%, imipramine (2 mg/kg) by 48%, amitriptyline (4 mg/kg) by 49%, phenytoin (4 mg/kg) by 53%, pyridinol (0.3 mg/kg) by 58%. Intragastric administration of water did not change PD. The results indicate that while psychotropic drugs given alone do not affect significantly the gastric mucosal barrier, they may potentiate the damaging action of ethanol on this barrier.

Animals↗

PubMedDate not supplied

[Idiopathic epidural lipomatosis of the vertebral canal].

Epidural lipomatosis is most frequently seen in patients on chronic steroid treatment. Only fourteen cases of idiopathic spinal epidural lipomatosis have been described. In this report we present an additional case of this condition in a 38 year-old man.

Adult↗