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Biomedical subjects

J Michael

Publications and source records attributed to J Michael.

156 records · Page 9Linked to original sources
PubMed1976

[Treatment of ulcus cruris. Clinical experiences using the Ulcrux cream and powder].

In an open trial 102 ulcera cruris of chronic venous genesis were treated locally with both Ulcrux Powder and Ointment in 54 female and 48 male patients over a period of 30 days. A positive result was obtained as to the shrinking of the wound area, the diminution of the substance defect, the development of granulations and the tendency towards epithelialisation. The influence on the cleansing of the wounds and on traumatic pain was also very favourable. Due to the rapid cleaning of the ulcera from necrotic films and to the good healing up tendency the therapeutic result was considered good to excellent with 81 patients (79,4%). Local side effects did not occur; the compatibility was also considered good in all cases. These test results prove that the combined treatment of chronic venous ulcera cruris with Ulcrux Ointment and Powder has real therapeutic advantages and seems to be superior to the traditional local forms of treatment.

Acetates↗
PubMed1976

Recurrent haematuria: role of renal biopsy and investigative morbidity.

The usefulness of renal biopsy in investigating unexplained haematuria was assessed by a study of 33 adults referred consecutively with this syndrome. Unequivocal abnormalities were seen on light microscopy or immunofluorescence in 31 of the 33 specimens of renal tissue examined. In 18 patients deposits of IgA were present in the mesangium. Loin pain occurred in only two of the 18 patients with mesangial IgA deposits, compared with 11 of the 15 patients without these deposits. Seven of the nine women in this series had had loin pain compared with only six of the 24 men. Thus a woman with loin pain and haematuria was not likely to have mesangial IgA nephropathy but this was found in 14 of the 18 men with unexplained painless haematuria. Failure to appreciate the role of renal biopsy in the investigation of unexplained haematuria may result in unnecessary radiology, considerable morbidity, and even in unjustified nephrectomy.

Adolescent↗
PubMed1974

Statistical inference for individual organism research: mixed blessing or curse?

Descriptive and inferential statistics are described as judgemental aids, stimuli to which the scientist can more easily react than to his raw experimental results. The increasing emphasis on the significance test as the main judgemental aid utilized in experimental psychology is credited with several harmful effects on experimental practice. The area known as "the experimental analysis of behavior" has so far escaped most of these harmful effects, but now we see an increased interest in the development of appropriate significance tests for individual organism research. This interest is based on the view that it is not possible to effect adequate levels of experimental control with much human applied research, and that in such cases a significance test would be quite valuable as a judgemental aid, both of which points are considered to be essentially incorrect, and if accepted, potentially harmful.

Journal Article↗
PubMedDate not supplied

A biotin-avidin based screening test for methamphetamine in urine.

A biotin-avidin based screening test for methamphetamine in urine samples has been developed. The assay method utilizes the immunoprecipitin reaction between an antibody to methamphetamine and a conjugate prepared by complexing avidin with a biotinyl amphetamine derivative. The rates of the immunoprecipitin reaction is monitored on the Beckman ARRAY 360 nephelometer. Methamphetamine inhibits the precipitin reaction, and the extent of inhibition allows the quantitation of methamphetamine in the urine samples. Using a cut-off value of 0.7 microgram ml-1, the assay correctly predicted 83 of 84 samples (98.8%) confirmed to be positive by GC-MS (> 500 ng ml-1). Of 59 GC-MS confirmed negative samples, 46 samples were found to be negative by this method as compared to 34 samples determined with the EMIT assay. Within-run and between-run relative standard deviations near the cut-off value were less than 4%. Cross-reactivity with amphetamine was < 7%.

Antibodies↗
PubMedDate not supplied

A pediatric survey for the National Highway Traffic Safety Administration: emergency medical services system re-assessments.

Emergency medical services for children, or EMSC, is still a relatively underdeveloped component of most state and local EMS systems. Advocacy and funding for EMSC from the federal EMSC Program, availability of many useful EMSC products, and the rapidly enlarging literature in EMSC have created heightened awareness and interest in improving systems for pediatric emergency, trauma, and critical care. The new National Highway Traffic Safety Administration (NHTSA) EMS Technical Assistance (TA) re-assessment program, the second version of the successful original TA Program from 1988 to 1996, provides an ideal opportunity for state EMS professionals to evaluate EMSC capabilities and to integrate new EMSC products and services. The history of the TA Program reflects the evolution of EMS itself and indicates a historical inattention to children's issues, but re-assessment TA teams now have much useful intervening EMSC history to draw upon and a clear philosophical mandate to integrate children more fully in EMS system planning and management. In order to facilitate state-of-theart reviews of EMSC within state EMS systems, a pediatric survey for the NHTSA re-assessments is presented. The survey, developed with the input of EMS administrators and physicians and approved by the National Association of State EMS Directors, follows the original ten-component model for EMS system review. It is intended for optional use within the overall EMS review process.

Child↗
PubMedDate not supplied

The treatment of diabetic renal failure by continuous ambulatory peritoneal dialysis.

During the 6-year period 1981-1987, 309 patients started chronic ambulatory peritoneal dialysis (CAPD), of whom 75 (24%) had diabetes. Despite severe peripheral vascular problems (20%), ischaemic heart disease (90%), and complete blindness (21%) the 1-year patient survival on CAPD was 88%. The actuarial patient survival for diabetic patients was similar to that of the non-diabetic cohort over the first 18 months but fell to 48% (compared to 70% in non-diabetic patients) at 3 years. Complications associated with CAPD, including the incidence of peritonitis, were no different between the diabetic and non-diabetic patient populations. Successful treatment for end-stage renal disease (ESRD) in diabetic patients can be achieved and justified in a liberal selection programme for the treatment of diabetic ESRD.

Adult↗
PubMedDate not supplied

Treatment of vasculitic IgA nephropathy.

BACKGROUND: Patients with IgA nephropathy and histological vasculitic/crescentic lesions have a poor prognosis. We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these lesions and thereby prevent progression to glomerular sclerosis and renal failure. METHODS: Sixteen patients with IgA nephropathy and a vasculitic/crescentic glomerulonephritis diagnosed by renal histology were treated with a reducing course of prednisolone (initial dose 60 mg/day). Six patients also received cyclophosphamide (2 mg/kg/day) for three months followed by azathioprine (100 mg/day) in five patients. Ten patients received azathioprine (100 mg/day) in addition to prednisolone. The median duration of treatment was 12 months (range 5-30 months). At the end of treatment each patient had a second renal biopsy. RESULTS: Following treatment there was a significant reduction in the proportion of glomeruli with acute vasculitic lesions from a median of 17.4% (range 4.8-57.5%) to 0 (range 0-15.8%) (p=0.001). There was an increase in the proportion of globally sclerosed glomeruli from a median of 13.4% (range 0-44.4%) to 21.5% (range 0-90%) after treatment but this did not significantly differ from baseline (p=0.24). The proportion of renal cortex with chronic tubular atrophy increased from 2.55% (0.4-57.7%) to 11.3% (0.3-61%) (p=0.09). The median duration of follow-up was 30 months (inter-quartile range 6-30 months). At both 12 and 24 months there was no significant increase in serum creatinine. Four patients, however, developed end-stage renal failure between 24 and 81 months. CONCLUSION: In this retrospective study we show that treatment with steroids and immunosuppressants leads to healing of vasculitic lesions and may thus arrest progression of glomerular scarring.

Adolescent↗