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Biomedical subjects

J Metzger

Publications and source records attributed to J Metzger.

At least 271 records · Page 15Linked to original sources
PubMedDate not supplied

[Neurological follow-up of glioblastomas treated by chemotherapy. Therapeutical incidences (author's transl)].

The authors describe the essential neurological complications observed during the follow-up of glioblastomas treated by sequential chemotherapy. They were studied on the basis of clinical, isotopical, CT scanner and or anatomical data. The most frequent complications are: epilepsy, acute neurological deficiency and intracranial hypertension. The diagnostic significance of the complications are discussed. Usually, they expresse a tumour extension. However, the recurrence presents varied aspects. It can be infiltrating and extensed, multifocal, focal, cystic ou pseudocystic. In the majority of cases the morphological, topographical and evolutional characters can determine the therapeutical attitude.

Adult↗
PubMedDate not supplied

[Clinical and therapeutic pitfalls of a bilateral acoustic neurinoma (author's transl)].

A case of bilateral fluctuating deafness accompanied by vertigo and assumed to be Menier's syndrome, a diagnostic hypothesis supported by the effectiveness, on repeated occasions, of medical treatment. In fact, progressive worsening of hearing led to the finding of a bilateral perceptive deafness with a complex vestibular syndrome, whilst tomograms of the petrous temporal bones revealed bilateral acoustic neurinomas. The results of special investigations in this case are analysed: audiometry, Sisi (?) test adaptation, nystagmography, in the light of the radiological findings. It was decided to operate upon the tumour which was larger radiologically. In addition, it revealed multiple neurofibromas of neighboursing nerves (von Recklinghausen's disease). The mid-term course is described. The article ends with a review of clinical concepts in such cases and an attempt to classify therapeutic attitudes to bilateral acoustic neuromas.

Adult↗
PubMedDate not supplied

[Three hypothalamic tumours: clinical, biologic, X-ray and therapeutic study (author's transl)].

On the basis of 3 cases of hypothalamic tumours (glioma of the hypothalamus or of the stem of the pituitary, glioma of the hypothalamus or of the optic chiasma, pinealoblastoma), the authors emphasise: (1) the existence of a special endocrine "formula" since it often combines anterior pituitary insufficiency, diabetes insipidus and moderate hyperprolactinaemia; (2) the remarkable efficacy, in all 3 cases, of cobalt therapy, tumour regression becoming complete during the 6 to 10 months following the end of radiotherapy; (3) the post-radiotherapeutic endocrine complications, endocrine deficit becoming greater whilst the tumour disappeared; (4) the diagnostic possibilities and above all regular surveillance now made possible by tomodensitometry.

Adolescent↗