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Biomedical subjects

J Metz

Publications and source records attributed to J Metz.

At least 289 records · Page 16Linked to original sources
PubMed1972

Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.

The effect of trimethoprim in various concentrations was tested on the folate-dependent deoxyuridylate methylation reaction in human bone marrow cultures. A slight effect was demonstrated at a concentration similar to that achieved in the plasma in patients taking the conventional therapeutic dose of trimethoprim. When a tenfold greater concentration was used, the effect became more pronounced. These findings are in agreement with reports of some mild haematological changes associated with the use of trimethoprim and offer an explanation for such changes.

Anti-Infective Agents↗
PubMed1971

Impaired cellular immunity in kwashiorkor with improvement after therapy.

Children with kwashiorkor showed a high incidence of deranged cellular immunity as evidenced by impairment of delayed cutaneous hypersensitivity reactions to candida and diphtheria toxoid antigens and of lymphocyte transformation after phytohaemagglutinin stimulation. This may contribute to their susceptibility to infection. A correlation was shown between the degree of impairment of tests of cellular immunity and the severity of the kwashiorkor. Once recovery was initiated the skin tests gave the expected positive results and the lymphocyte transformation index improved. Protein deprivation may result in impaired deoxyribonucleic acid (DNA) synthesis and in atrophy of both the thymus and the lymphoid tissue.

Antigens↗