Biomedical subjects

J Metz

Publications and source records attributed to J Metz.

At least 253 records · Page 14Linked to original sources

PubMed1975

[Acquired epidermolysis bullosa in Crohn's disease].

A case of epidermolysis bullosa acquisita associated with colitis granulomatosa (Crohn's disease) is reported. Although the cutaneous lesions of this unusual disease resemble in their clinical, histological and ultrastructural features to those of the hereditary epidermolysis bullosa dystrophica, the epidermolysis bullosa acquisita has to be regarded as a separate entity among the blistering epidermolysis because of its late manifestation in adults without evidence of hereditary disorders. The deposits of immunoglobulins in the involved skin of the acral areas demonstrated fluorescentmicroscopically are discussed in regard of a possible etiopathogenic relation with the primary irritated intestinal disease.

Adult↗

PubMed1975

Vitamin B12 and its binding proteins in the serum of some wild game species.

The concentration of vitamin B12 and its binding proteins was measured in the impala, nyala, wildebeest, zebra, bushpig, warthog, and rhino, all existing in their natural state. Marked differences were found between some species. The variations observed are probably true species differences, unrelated to environmental factors.

Animals↗

PubMed1975

[Demonstration of pathogens in lymphogranuloma inguinale. An electron microscopy study].

A case of lymphogranulomatosis inguinalis is reported, in which the definite diagnosis was made by the electronmicroscopical demonstration of Chlamydia lymphogranulomatosis in the lymphnode. The value of this diagnostical method is discussed in regard to verifying the diagnosis and in comparison with other methods. The lifecycle of the Chlamydia lymphogranulomatosis could be demonstrated electronmicroscopically. Its exceptional position in microbiological classification is discussed.

Adult↗

PubMed1975

Normal vitamin B12 turnover in subacute combined degeneration of the spinal cord.

Vitamin B12 turnover studies were carried out in 2 patients with pernicious anemia and subacute combined degeneration of the spinal cord. The retention of a tracer dose (0.5 mug) of intravenously administered 58Co-labeled vitamin B12 in these 2 patients was measured by whole-body monitoring over periods of 94 and 134 days. Vitamin B12 turnover (per cent per day) was calculated and the results compared with normal subjects and with pernicious anemia patients having no neurologic dysfunction. The loss of radioactive-B12 from the body was described by a single exponential model, confirming that the loss of vitamin B12 takes place as though from a single pool. There was no difference in vitamin B12 turnover between the patients with subacute combined degeneration of the spinal cord and normal subjects or other pernicious anemia patients without neurologic involvement. These findings contradict the suggestion that the development of neuropathy in vitamin B12 deficiency might be related to an increased requirement for vitamin B12.

Adult↗

PubMed1975

[Differences in concentration of free amino-acids in fetal and maternal compartments at the end of normal and pathologic pregnancies (author's transl)].

Free amino-acids in the fetal and maternal compartments towards the end of normal and pathologic pregnancies were examined with gas chromatography. Blood was obtained from the cubital and uterine veins and the femoral artery of the mother, from the umbilical artery and vein and the amniotic fluid during Caesarean section. There were only minor differences of concentration of free amino-acid between normal and pathologic pregnancies. Since it is possible in principle that there is mutual balance between maternal and fetal compartments, assessment of changes in amino-acid concentration during dia- and paraplacentar exchanges is usable only with reservations.

Amino Acids↗

PubMed1974