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Biomedical subjects

J Messer

Publications and source records attributed to J Messer.

At least 127 records · Page 7Linked to original sources
PubMed1979

[Peripheral retinal lesions in the premature infant].

The periphery of the retina was examined with the use of contact lenses at the age of 5 years in children who were born prematurely and weighed less than 1,500 g at birth. In this retrospective series 65% of the children were found to have lesions similar to the classical findings in retrolental fibroplasia although only to a minor degree. Low oxygen levels with a short duration of the exposure cannot completely prevent these sequalae. This retinopathy which is limited to the periphery, may account for the frequency and severity of myopia in children who were premature. Later in childhood and more rarely retinal detachment or tears may occur which cause severe visual impairment.

Child, Preschool↗
PubMed1979

Right-to-left ductal shunt and transcutaneous PO2.

The continuous monitoring of the PO2 with double sensors, pre- and post-ductal, is very interesting during the neonatal period; the magnitude of the right-to-left ductal shunting, related to high pulmonary vascular resistance, is well evaluated by the hyperoxemia test. This noninvasive method allows a reliable observation of the pulmonary vascular response to oxygen, alkaline solutions, or tolazoline infusion.

Blood Gas Analysis↗
PubMed1979

[Present status of retrolental fibroplasia in France].

A national survey showed that retrolental fibroplasia still exists in France, as it does in other countries of the world. Retrolental fibroplasia is a condition that principally affects low birth weight premature babies in whom oxygen therapy has not been adequately controlled. The premature babies who have apnaeic attacks are most risk. Strict control of all oxygen therapy, preferably using continuous monitoring techniques together with other changes in the methods of treatment should reduce the incidence of this condition.

Apnea↗
PubMed1978

[Visual future of prematures].

The retinal periphery of 60 premature children now between 5 and 8 years of age and with a weight at birth equal or less than 1,500 g has been investigated. In 20% of these children, pigmentary modifications were noted which were often associated with chorioretinal atrophy. Polymorphic vascular abnormalities were seen in 14% of the cases, i.e. sinuous vessels of irregular caliber or neovascularization. Abnormalities of the vitreous body were also noted in 12% of the patients with glial bags on the periphery and sometimes potentially dangerous tractions folds (4%). All these abnormalities could cause complications such as retinal tear, retinoschisis or retinal detachment. Even if these signs are discrete, they can later on be the source of complications. Refraction studies revealed 30% of myopic children. The most important group had myopias equal or higher than 8 d. The characteristics of the myopia of premature children are its constancy (all premature children are myopic at birth); its importance (it depends on birth weight and on the severity of the retinopathy), and its evolution (the myopia of premature children does not evolve or evolves very slightly).

Birth Weight↗
PubMed1978

The diagnostic significance of the immunoglobulin A to M and A to total ratios in the pancreatoduodenal fluid of patients with benign and malignant pancreatic diseases.

Immunoglobulins A, M and G in the pancreato-duodenal fluid (PDF) of 35 pancreatic disease-free individuals and 48 patients with chronic pancreatitis (25), hypersecretory disorders (10), renal transplanted (4) and with pancreatic cancer (9), were determined by a single radial immunodiffusion method. Although a trend of immunoglobulin hypersecretion in benign diseases and hyposecretion in malignancies was present, individual levels of Ig-A and Ig-M differed statistically only between cancer and other groups. Calculating the ratios of Ig-A to Ig-M (A/M) and Ig-A to total immunoglobulin contents (A/T) in the PDF of patients with chronic pancreatitis or cancer, however, a significantly higher or lower ratio, respectively, was found compared to control group. Differences in A/M ratios could not be detected between patients with benign diseases, but were constantly present when these patients were compared to pancreatic cancer. The underlying mechanism(s) of the disturbed immunosecretory system in pancreatic diseases remains speculative. Nevertheless, immunoglobulin measurements in the PDF of patients with pancreatic diseases offer a simple diagnostic aid in clinical differentiation of pancreatic pathology.

Body Fluids↗
PubMed1978

[Retinal dysplasia with hydrocephalus (author's transl)].

A Study is described of a family in which four children of the same generation died during early childhood; three of them had an obvious hydrocephalus. Two of the latter could be examined clinically, and their eyes removed for pathology. One of them presented clinically bilateral leucocoria; histology showed a total detachment of a dysplastic retina, with absence of development of the vitreous. The other child had apparently normal eyes. Yet on microscopical examination there was a discrete retinal dysplasia without retinal detachment in both eyes, and a persistent hyaloid artery, in one. This association of hydrocephalus with retinal dysplasia is clinically and genetically different from other types of retinal dysplasia.

Abnormalities, Multiple↗
PubMed1978

[Neo-natal neutropenia induced by anti-NA 2 allo-immunization. Serological and clinical study of 2 cases in a family].

A severe neutropenia in a 2 day old newborn drew attention to anti-HLA and NA 2 antigranulocytic antibodies in the maternal serum. Close supervision from birth of a younger sibling demonstrated a neutropenia on the 5th day of life. Serological investigation showed the anti-NA 2 antibody to be responsible in both cases. A good result with total blood replacement of leucocyte-free blood in the second case would advocate this treatment in cases of severe immunological neutropenia.

Agranulocytosis↗
PubMed1977

A long term evaluation of infants who received a beta-mimetic drug while in utero.

The administration of beta-mimetic drugs to pregnant women poses the problem of possible long-term repercussions in the children born to these mothers. 42 children from women who had been treated with 60-80 mg a day of ritodrine hydrochloride (Pre-par), during a period varying from 3 to 93 days, were closely matched with infants from untreated mothers. Each child, (aged from one to 3 years), was fully investigated on the basis of: a detailed questionnaire to the mother; careful clinical examination; assessment of psychomotor development; the Denver test; electrocardiography and urine analysis. There was no statistically significant difference between the two groups for any of the variables of development that were studied. One child had left ventricular hypertrophy, which was probably incidental. It is concluded that administration of ritodrine hydrochloride to pregnant women induces no harmful long-term effects in their offspring.

Body Height↗
PubMed1976

[Severe hyperosmolarity caused by dietary error in the newborn. A disorder of particular concern in migrants].

Hyperosmolarity as a result of dietary error is a fairly common condition. It is more grave than "thirst fever", the benign reputation of which should not be taken too lightly. The consequences may be serious: death or sequelae related to vascular thrombosis or cerebral lesions. Prevention should be possible in most instances as long as obstetricians, paediatricians, midwives and nursery nurses are aware of the danger of overconcentrated milk formula. Its treatment remains fraught with hazard.

Animals↗