Imipramine, doxepin, mianserin, pipotiazine and sulpiride, all active upon behavioural despair test of Porsolt and coll. in unique administration, are devoid of activity, with the exception of mianserin and sulpiride, in repetitive administration. It would be possible that a diminution of cerebral levels of neurotransmitters NA and DA after repetitive administration of imipramine, doxepin and pipotiazine (or an over-sensitivity to serotonin in the case of imipramine and doxepin) and an increase of these levels after repetitive administration of mianserin and sulpiride (with an antiserotonin activity for mianserin) would be responsible for these discrepancies.

Animals↗

PubMedDate not supplied

[Prevalence of drepanocytosis in Guadeloupe. A systematic detection in kindergartens].

The authors appreciate the prevalence of drepanocytosis in a supposed healthy group of blood donors at the Transfusion Center. They propose to carry out a systematic detection of the various hemoglobin types existing in the isle at all stages of active-life: birth, school-time, prenatal consultations, controls for enrolment in the army, etc. They describe the action of the "mother and child protection service" which could develop information and genetic advice to try to limit the dissemination of the drepanocytic tract as well as to avoid the birth of homozygotes. To improve the control, they suggest to print the hemoglobin type on the blood group card of each citizen.

Adult↗

PubMedDate not supplied

[Effect of sulpiride on the nalorphine withdrawal symptoms in the macaca].

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Animals↗

PubMedDate not supplied

[Determination of the monkey Macaca of pentazocine tolerance and research using the nalorphine test, on the physical dependence it can induce].

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Animals↗

PubMedDate not supplied

[In vivo evaluation of insulin sensitivity and clinical applications].

During the past decade, the potential implications of insulin resistance were recognised by clinicians ranging from endocrinologists to cardiologists. Central to this expanding interest is Reaven's hypothesis that tissue resistance to the effects of insulin is a factor linking various metabolic disorders and coronary heart disease. This review critically describes the different approaches for the evaluation of insulin sensitivity in vivo. Qualities and limitations of several investigative techniques are discussed, such as anthropometric indexes, basal biological indexes, insulin suppression tests and insulin tolerance tests. The two most widely used methods for quantifying insulin sensitivity are the euglycaemic hyperinsulinaemic clamp and the intravenous glucose tolerance test with minimal model analysis. Insulin resistance occurs in many aetiologically diverse human disorders. Genetic syndromes with extreme insulin resistance are very uncommon. Insulin resistance is frequently associated with obesity, type 2 diabetes and essential hypertension. The insulin resistance syndrome called syndrome X includes impaired insulin-mediated glucose uptake, impaired glucose tolerance, hyperinsulinaemia, hypertension, dyslipidaemia and haemostatic disorders. Finally, the clinical significance of high values of insulin sensitivity is discussed.

Animals↗