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Biomedical subjects

J Meng

Publications and source records attributed to J Meng.

At least 127 records · Page 7Linked to original sources
PubMed1994

[Careful dissection of the pelvic plexus helps alleviate urinary retention following radical hysterectomy].

Radical hysterectomy remains to be the treatment of choice for carcinoma of the uterine cervix. As pelvic nerve plexuses are distributed in the operative field, damage to the plexuses is likely to occur, which is responsible for the post-operative atonia of the urinary bladder and urinary retention. To reduce the incidence of this postoperative complication, the composition and distribution of the pelvic nerve plexuses in relation to the utero-sacral ligament and cardinal ligament of the uterus and paravaginal tissues were carefully dissected on 11 adult female cadavers. Based on the anatomic study, due precautions were made to avoid damage to the pelvic nerve plexuses during pelvic dissection for radical hysterectomy. As a result, the duration of postoperative urinary retention was significantly reduced while the 5- and 10-year survival rates remained unchanged.

Adult↗
PubMed1994

Morphologic changes of apoptosis induced in human chronic myelogenous leukemia "blast" cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase.

Several inhibitors of the arachidonic acid-metabolizing enzyme, 5-lipoxygenase reduce proliferation of hematopoietic and non-hematopoietic cells and cell lines and some cells undergo limited differentiation. Cells were cultured from patients with chronic myelogenous leukemia in "blast" crisis with the selective inhibitor of 5-lipoxygenase, SC41661A[3-(3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)hiol]-N-me thyl-N-[2-(2- phridinyl-propanamide)]. Cells cultured for 3 to 5 days with 40 microM SC41661A exhibited reduced cellular numbers along with ultrastructural changes and DNA laddering characteristic of apoptosis. Similar culture conditions reduced proliferation of U937 monoblastoid cells. In U937 cells, the ultrastructural features of apoptosis were not observed at 72 hours, when DNA laddering was present and cell numbers were reduced, but was present after 144 hours of culture. Dissociation between certain morphologic and biochemical sequelae of apoptosis has been described in other systems. These observations are of interest since the induction of apoptosis in dividing chronic myelogenous leukemia (CML) cells by a non-cytotoxic agent suggests paradigmatically new sites for therapeutic intervention.

Amides↗
PubMed1994

Carbohydrate drinks and cycling performance.

We compared the effects of similarly tasting orange flavored drinks containing 0% (P), 6.4% (E1), and 10% (E2) carbohydrate (CHO) using 12 well-trained cyclists (VO2max = 5.0 l/min-1) on metabolic responses to exercise (EX) and a sprint type performance ride (PR). Each subject completed 3 separate 2 h EX bouts at 65% VO2max followed by a PR identified as the time in sec to complete 500 revolutions at a constant belt resistance of 29.4 N (ANOVA*). The CHO feedings or placebo of 3 ml/kg body weight were given double blind and counter-balanced at 0 min and every 20 min thereafter during EX. Blood samples were drawn and core temperature (Tr) was recorded at 0, 30, 60, 90, and 120 min of EX and 1 min post PR. Blood samples were analyzed for glucose (G) and lactate [LA-]. Blood G at 0 min were similar; however, at 120 min, G was 3.96 mM for P*, 4.57 mM for E1, and 4.77 mM for E2. Blood [LA-] remained similar throughout EX averaging (P, 2.6 mM; E1, 2.9 mM; E2, 2.5 mM). Tr at 120 min was also similar (P, 38.5 degrees C; E1, 38.6 degrees C; E2, 38.3 degrees C). Mean PR times for P(264.4 s)**, E1 (255.3 s)*, E2 (252.4 s)* indicate consumption of a CHO drink during EX improves PR. Furthermore, a 10% CHO drink improves PR more than a 6.4% CHO drink.

Adolescent↗
PubMed1993

Modeling lag phase of nonproteolytic Clostridium botulinum toxigenesis in cooked turkey and chicken breast as affected by temperature, sodium lactate, sodium chloride and spore inoculum.

The length of the lag phase (LP) of toxigenesis in commercially cooked turkey meat stored under vacuum was determined as affected by 0, 1.2, 2 and 3% sodium lactate (L), 0, 1 and 2% NaCl (S), spore (pool of nonproteolytic B and E strains: B2, B17, B197, B706, E211, E250, E KA-2 and E Beluga) inoculum (I) of 10(-2) to 10(4), storage temperature (T) of 4, 8, 12, 16, 20 and 30 degrees C and their interactions. The time from inoculation to the detection of first toxic sample was defined as LP. Using regression analysis the following model predictive of LP of C. botulinum toxigenesis in the cooked turkey breast was derived: Log(1/LP) = -2.2877 -0.1235(S) -0.2174(L) +0.4391(square root of T) +0.0204(square root of T) (I). The model explained 94.5% of the variation in results, in which square root of T was the most influential factor (65%), followed by L (21.2%), interaction of I and square root of T (4.9%) and S (3.4%). The model predicted LPs longer than those observed in 28.3% of the comparisons, but only in 1% of the comparisons when the lower limit of the 90% confidence interval of LP was used. Similar trends on the effect of L on C. botulinum were observed in an inoculated chicken meat study. This study demonstrated quantitatively that increasing L and S concentrations and lowering of T had a beneficial effect on delaying toxigenesis.

Analysis of Variance↗
PubMed1992

Boy with a chromosome del (3)(q12q23) and blepharophimosis syndrome.

We report on a 6-year-old boy with de novo 46,XY,del(3)(q12q23) and bilateral blepharophimosis, ptosis, epicanthus inversus, in addition to multiple other anomalies. Since 4 previously reported cases of interstitial deletion of 3q involving 3q23 band are clinically similar, we propose this blepharophimosis sequence due to 3q23 deletion as a further "contiguous gene syndrome."

Adult↗
PubMed1992

Two patients with chromosome 6q terminal deletions with breakpoints at q24.3 and q25.3.

We report on 2 patients with de novo terminal deletion of 6q. The first was a 4-month-old boy whose karyotype was 46,XY,del(6)(q24.3); the second a 2-year-old girl whose karyotype was 46, XX, del(6)(q25.3). The main anomalies in both patients included mental retardation, minor craniofacial and cerebral anomalies, and cardiac defects. The characteristic manifestations were imperforate anus in the first patient, and retinitis proliferans and a triatrial heart in the other. Comparison of clinical findings of our 2 patients with those of 18 previously reported patients with similar phenotypes suggests that terminal deletion of the 6q23 or 6q25 band is critical in producing the main anomalies of del(6q) syndrome.

Abnormalities, Multiple↗
PubMed1992

[Effect of electroacupuncture on myocardial oxygen metabolism and pH of coronary sinus blood during experimental angina pectoris].

The experiments were performed on 30 healthy mongrel dogs, intubation was taken in the left anterior descending coronary (LAD), the blood in carotid was transported to LAD through a peristalic pump, the blood flow was reduced to 3-5 ml/min, thus acute myocardial ischemia was produced. Basing on this condition, 0.1-0.16 ml bradykinin (2 ug/ml) was given into LAD coronary before recording to produce angina pectoris. The effects of electroacupuncture (EA) at "Neiguan" area on myocardial oxygen metabolism, pH of coronary sinus blood and myocardial contractile force were observed (EA intensity 5 volts, frequency 1-20 Hz). The results are as follows: 1. EA could reduce obviously A-V difference of blood oxygen capacity (Ca-vO2) and the rate of myocardium extracting oxygen (O2E), thus reduced obviously oxygen consumption of ischemic myocardium. 2. EA could reduce V-A difference of carbon dioxide partial pressure (Pv-aCO2), prevent the decrease of pH of coronary sinus blood (PHv), this indicated that EA could prevent accumulation of acidic metabolic products. 3. EA could increase myocardial developed tension (DT) of ischemic area, strengthen myocardial contractile force of ischemic area. Above results indicated that EA could reduce oxygen consumption of ischemic myocardium, prevent the decrease of pH of coronary sinus blood, thus myocardial cell acidosis was prevented, myocardial contractile force was strengthened. It might be the mechanism of acupuncture treating coronary heart disease.

Angina Pectoris↗
PubMed1991

[The absorption of Fe, Zn, Cu in siwu, sijunzi, and Liuwei dihuang decoction by small intestine in rats].

In this study the absorption of Fe, Zn and Cu in decoctions of siwu decoction, sijunzi decoction and liuwei dihuang decoction by the small intestine in anesthetized rats was observed. The experimental results showed that the absorption of Cu and Fe from siwu decoction was much higher than that from other decoctions which might be related to the hematopoietic function of Cu and Fe rich in the decoction.

Animals↗
PubMed1990

[Change of myocardial glucose and free fatty acid metabolism and effect of electroacupuncture on them during experimental myocardial angina].

This study was designed to observe the effect of electroacupuncture applied at "Neiguan" point on myocardial Glucose (GLU) and Free fatty acid (FFA) metabolism of dogs with experimental myocardial angina, experimental myocardial angina model was set up in 20 healthy mongrel dogs with reducing the volume of blood flow of left anterior descending coronary (LAD) and intracoronary administration of bradykinin. The results showed that arterial-venous difference of glucose (GLUa-v) was increased significantly and arterial-venous difference of free fatty acid (FFAa-v) was decreased significantly after experimental myocardial angina. with prolongation of the period of myocardial ischemia and increase of the times of myocardial angina, in control group, GLUa-v was increased lightly and FFAa-v was markedly decreased (P less than 0.05), this showed that FFA uptake of ischemic myocardium was markedly decreased. Electroacupuncture at bilateral "Neiguan" point resulted significant decrease of GLUa-v and slight increase of FFAa-v. There were statistical significance between the two groups (P less than 0.05) in GLUa-v and FFA-v. Aterial blood free fatty acid had not significant change after experimental myocardial angina and electroacupuncture had not marked effect on it. The above results indicated that experimental myocardial angina result in metabolic disorders of myocardial glucose and free fatty acid. Electroacupuncture may reduce glucose uptake and increase free fatty acid uptake of ischemic myocardium. Thus improved metabolic disorder of ischemic myocardium.

Acupuncture Therapy↗
PubMed1990

[The comparison of changes of the facial temperature after acupuncturing point of hand and foot-yangming meridians by the thermography].

With thermographic technique, We observed changes of the facial temperature after acupuncturing Hegu (L14) and Zusanli (S36) in 65 patients (103 cases in all) with facial nerve paralysis. The observation showed that the average of Hegu group was higher than that of Zusanli group. The result explained that the effect of acupuncture at points of hand-yangming meridian was bigger than that of foot-yangming meridian on the facial temperature.

Acupuncture Points↗
PubMed1990

Effects of the heat-tonification method on the surface temperature of the body observed by infra-red thermography.

With the infra-red thermography, 73 tests of the effect of Heat-Tonification maneuvers on body surface temperature were made. The experiments showed that application of Heat-Tonification produced marked elevation of temperature at the site of puncture, over the face and the front of the neck. The differences between pre- and post-needling temperatures were statistically significant (P less than 0.02 and P less than 0.01). Furthermore, 44.8% of the tests showed elevation of temperature over the trunk and extremities, and the distribution of temperature elevation followed the course of the meridians mostly. The findings demonstrated that the Heat-Tonification method mobilized Qi and activated Blood through influence over the vegetative nervous system that led to readjustment of blood circulation.

Acupuncture Therapy↗