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Biomedical subjects

J Medlin

Publications and source records attributed to J Medlin.

12 recordsLinked to original sources
PubMed2001

Array of hope for gene technology.

A Washington-based bioinformatics company is developing sophisticated DNA microarrays that should help researchers measure and analyze gene expression faster, more economically, and with greater precision than ever before possible. The FlexJet system, as the microarray product is known, uses inkjet technology to propel microscopic strands of DNA nucleotides onto slides, "printing" arrays of DNA molecules in a process not unlike the manner in which a printer deposits ink onto paper, forming distinct patterns of characters and images. Microarray technology may revolutionize the field of toxicogenomics by helping scientists target new drugs, discover gene function, determine biologic pathways, and better understand diseases such as cancer, cystic fibrosis, and cardiovascular disease at the molecular level.

Computers↗
PubMed2000

Expression of zebrafish fkd6 in neural crest-derived glia.

The zebrafish fkd6 gene is a marker for premigratory neural crest. In this study, we analyze later expression in putative glia of the peripheral nervous system. Prior to neural crest migration, fkd6 expression is downregulated in crest cells. Subsequently, expression appears initially in loose clusters of cells in positions corresponding to cranial ganglia. Double labelling with a neuronal marker shows that fkd6-expressing cells are not differentiated neurones and generally lie peripheral to neurones in ganglia. Later, expression appears associated with the posterior lateral line and other cranial nerves. For the posterior lateral line nerve, we show that fkd6-labeling extends caudally along this nerve in tight correlation with lateral line primordium migration and axon elongation. Expression in colourless mutant embryos is consistent with these cells being satellite glia and Schwann cells.

Animals↗
PubMed1999

New microscope gives scientists the inside scoop on living cells.

Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmental insults to live cells.

Cell Physiological Phenomena↗
PubMed1997

Germ warfare.

Explore the source record for details and available documents.

Anti-Infective Agents↗