Biomedical subjects

J McRae

Publications and source records attributed to J McRae.

At least 37 records · Page 2Linked to original sources

PubMed1976

Determination of trace hazardous organic vapor pollutants in ambient atmospheres by gas chromatography/mass spectrometry/computer.

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Air Pollutants↗

PubMed1976

Technetium radiopharmaceuticals as diagnostic organ imaging agents.

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Humans↗

PubMed1976

Chemistry of 99mTc tracers. II. In vitro conversion of tagged HEDP and pyrophosphate (bone-seekers) into gluconate (renal agent). Effects of Ca and Fe (ii) on in vivo distribution.

Sodium gluconate transforms the bone-seekers 99mTc-HEDP and 99mTc-pyrophosphate into the renal agent 99mTc-gluconate. In these in vitro processes, pyrophosphate is displaced faster than HEDP, while the HEDP reaction is accelerated by calcium ions. The in vivo distributions of these bone and kidney agents are altered by the prior local injection of calcium or iron(II). These transformation and translocation phenomena are explained in terms of the mechanistic behavior of Tc(IV) complexes.

Animals↗

PubMed1975

The distribution of various water soluble radioactive metalloporphyrins in tumor bearing mice.

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Animals↗

PubMed1975

Chemistry of technetium radiopharmaceuticals. I. Exploration of the tissue distribution and oxidation state consequences of technetium (IV) in Tc-Sn-gluconate and Tc-Sn-EHDP using carrier 99Tc.

The distribution in rats of the renal agent Tc-Sn-gluconate using both 99mTc and carrier amounts of 99Tc was similar. The same behavior was shown with the bone agent Tc-Sn-EHDP. The radiopharmaceutical consequences of the observed Tc(IV) oxidation state in these systems are explored.

Animals↗

PubMed1974