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Biomedical subjects

J McKinley

Publications and source records attributed to J McKinley.

10 recordsLinked to original sources
PubMed2003

Comparison of the lateral release rates in the press fit condylar prosthesis and the PFC Sigma prosthesis.

There are many different total knee replacements on the market. Most have undergone design changes since they were introduced. The manufacturers claim these changes are necessary to improve outcomes of their products. Johnson and Johnson changed their press fit condylar (PFC) knee to PFC Sigma. One of the reasons for the change was to improve patella tracking by combining the deeply radiused trochlear groove of the PFC cruciate sacrificing knee with the natural asymmetrical valgus angle of the PFC cruciate retaining knee. In 1995 we started a prospective audit of our knee replacements. We analysed our early outcomes to test this theory. Group 1 consisted of 468 patients who underwent 543 PFC replacements. Group 2 consisted of 359 patients who underwent 423 Sigma knee replacements. An audit nurse saw all the patients preoperatively and an American Knee Society Score was done. Operative details were recorded. Patients were followed up by an audit nurse at a dedicated knee clinic. The same surgeons using the same instrumentation carried out the operations. The change in design reduced the lateral release rate by 50% from 32 to 16%. The complications were similar in both groups and there was no difference in the outcomes at 6 months. The change in design from the PFC to the Sigma knee has had an effect in reducing the lateral release rate, without affecting the early outcomes. We plan to continue this audit to see if the change leads to less patellar problems in the future.

Arthroplasty, Replacement, Knee↗
PubMed2001

Generation of full-length cDNA libraries enriched for differentially expressed genes for functional genomics.

Here, we describe the application of a RecA-based cloning technology to generate full-length cDNA libraries enriched for genes that are differentially expressed between tumor and normal tissue samples. First, we show that the RecA-based method can be used to enrich cDNA libraries for several target genes in a single reaction. Then, we demonstrate that this method can be extended to enrich a cDNA library for many full-length cDNA clones using fragments derived from a subtracted cDNA population. The results of these studies show that this RecA-mediated cloning technology can be used to convert subtracted cDNAs or a mixture of several cDNA fragments corresponding to differentially expressed genes into a full-length library in a single reaction. This procedure yields a population of expression-ready clones that can be used for further high-throughput functional screening.

DNA, Complementary↗
PubMed1999

The quality of surgical information on the Internet.

The quality of surgical information on the Internet is variable. Content variation limits the use of the Internet as a reliable and safe information source both for both health professionals and patients. Medical information is a particularly sensitive area. Incorrect or misleading information may lead to potentially dangerous health behaviour, patients reading information intended for health professionals may misunderstand information or may get wrong expectations regarding treatment options.

Abstracting and Indexing↗
PubMed1997

Variable budgeting for staffing. Analysis and evaluation.

A successful resource-management system must be based on variable budgeting principles to account for fluctuation in patient census, methodically prepared through historical analysis of operations, carefully executed and monitored by accountable multidisciplinary managers. Significant attention must be paid to communication, positioning and stability of the patient care organization.

Budgets↗
PubMed1981

Experience with germ cell tumors of testicle at University of Iowa.

Between 1964 and 1979, 219 patients with germ cell testicular tumors were treated at the University of Iowa. In 79 nonseminomatous germ cell tumors various chemotherapeutic regimens were used. The response, salvage, and survival rates are compared. There is a definite trend toward better response rates and survival using the combination cisplatinum, vinblastine (Velban), and bleomycin. With this combination, 75 per cent of Stage II and III patients survived two years. The over-all response rate was 85 per cent, and 87 per cent of those with a complete response survived two years. Eighty per cent of deaths occurred within two years and 90 per cent within three years.

Antineoplastic Agents↗