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Biomedical subjects

J McKenzie

Publications and source records attributed to J McKenzie.

At least 73 records · Page 4Linked to original sources
PubMed1984

Costs and benefits of two doses of fluphenazine.

The relative costs and benefits of low- and conventional-dose neuroleptic maintenance therapy were evaluated in a double-blind comparison of 5 and 25 mg of fluphenazine decanoate administered every two weeks. Subjects were 50 patients fulfilling DSM-III criteria for schizophrenic disorder who had been successfully maintained with 25 mg or less of fluphenazine decanoate. A one-year survival analysis disclosed that there were no statistically significant differences between the two doses insofar as preventing relapse. Patients receiving the higher dose appeared to feel more uncomfortable, as indicated by higher scores on subscales of the Hopkins Symptom Checklist-90. In addition, patients receiving the higher dose had higher side-effect scores. These findings suggest that a substantial proportion of patients who are presently maintained with 25 mg or less of fluphenazine decanoate every two weeks will do just as well with as little as 5 mg.

Adult↗
PubMed1982

Delayed stimulus control: recall for single and relational stimuli.

In a discrete-trial symbolic matching-to-sample procedure, pigeons' left-key responses were reinforced following presentation of one center-key sample, and right-key responses were reinforced following presentation of another. Recallability was measured by the difference between log ratios of left to right responses following each sample. In Experiment 1, samples were successively presented same or different wavelengths in the relational discrimination, or individual wavelengths in the single discrimination. The rate at which recallability decreased with increasing delay since sample presentation was the same for single and relational discriminations, but the initial level of performance differed, indicating that the relational discrimination was more difficult. In Experiment 2, recall functions for easy and difficult discriminations between individual wavelengths also differed in levels of initial performance but not in rate of decrement of recallability over time. Recall for stimuli differing in complexity may therefore reflect differences in discrimination difficulty.

Animals↗
PubMed1979

Personality correlates in a sample of male nurses in the British Royal Air Force.

This descriptive study provides data relevant to two currently popular views of the male nursing image. Firstly, that male nurses tend to prefer the more technological or administrative aspects of nursing and secondly, that they exhibit to an unusually high degree what are commonly thought of as being amongst the more feminine personality traits. The sample consisted of 91 male RAF nurses working in RAF hospitals, and was of predominantly English nationality. Of the 39 SRNs in the sample 65.8% preferred general nursing to the more technical areas such as intensive care, operating theatre, orthopaedic and renal. The preference for general nursing was even greater, 76.1%, amongst the 30 SENs surveyed. The Eysenck Personality Questionnaire (EPQ) and a Level of Aspiration Test (LOA) were used to obtain measures of the personality traits of the sample. The scores obtained showed that the male RAF nurses were significantly less psychotic than male civilian nurses, male civilians or serviceman of similar age. They were also significantly less extraverted than servicemen as a whole and significantly more stable than the male civilian norm. A comparison of SRNs with SENs revealed only two significant differences. The SRNs were significantly less extraverted and had a significantly higher level of adpiration than the SENs.

Adult↗
PubMed1978

A study of three protocols of blood transfusion before renal transplantaion in the dog.

Three protocols of blood transfusion were evaluated in a canine model for (1) the strength and breadth of leukocytotoxin induction, (2) the induction of cell-mediated immunity against the blood donors, (3) haemagglutinin production, and (4) any effect on kidney graft survival. At the end of the transfusion schedule, each dog received a kindey graft and was given azathioprine and prednisolone postoperatively. All dogs were unrelated and blood donors were not used as kidney donors. All three transfusion protocols, comprising i.v. injections of blood twice weekly or every 2 weeks from one or three donors, induced unacceptably strong and broad leukocytotoxins. All transplants performed across a positive crossmatch failed to function. However, where a negative crossmatch was available, the trend of results was that the transfused dogs had better graft survival than nontransfused animals similarly treated with azathioprine and prednisolone. Only one dog produced haemagglutinins. Several animals had positive cell-mediated immunity against the blood donors, but the response was not strong and was frequently not sustained.

Animals↗
PubMed1977

Vater syndrome: hypothesis and report of two further cases.

Two cases are reported of the association of a group of abnormalities defined as the Vater syndrome, together with a hypothesis, based on the presence of normal cell death during embryogenesis, on how they occur together so frequently. Although the mechanism of normal cell death is unknown, adjacent cells are probably affected sublethally and subsequently recover. A teratogenic situation introduced simultaneously with the occurrence of normal cell death may further diminish the viability of those adjacent cells, causing increase in the necrotic zone and loss of both normal tissue and growth potential.

Abnormalities, Multiple↗