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Biomedical subjects

J McGuigan

Publications and source records attributed to J McGuigan.

At least 19 recordsLinked to original sources
PubMed2005

Life threatening hyperkalaemia with diarrhoea during ACE inhibition.

A 67 year old woman developed acute renal failure with serum potassium 9.4 mmol/l requiring emergency dialysis after seven days of diarrhoea while taking an ACE inhibitor for vascular disease. Review of the literature, the British National Formulary, and the patient information leaflets for each of the 11 ACE inhibitors currently marketed in the UK suggests that this potentially life threatening complication of ACE inhibition is not yet widely recognised.

Acute Kidney Injury↗
PubMed2003

Salmonella sepsis and miscarriage.

We present a case of a miscarriage at 16 weeks of gestation due to infection and transplacental passage of Salmonella group C. This was identified as being Salmonella Virchow from genital tract swab culture, and placental Gram-staining revealed numerous colonies of Gram-negative bacilli within the fibrin between the placental villi, confirming a true villitis associated with a hematogenous infection. Based on the patient's history, it was suggested that she had contracted the salmonella infection from eating undercooked eggs. Treatment of salmonella infection in pregnancy is controversial, and antibiotic therapy should be reserved for cases of invasive disease, using amoxicillin or a cephalosporin.

Abortion, Spontaneous↗
PubMed2003

Structure data entry using graphical input: recording symptoms for multiple sclerosis.

Structured Data Entry provides flexible and efficient input to the computer-based patient record. We have utilized the SDE approach to build a prototype interface for recording common symptoms associated with Multiple Sclerosis (MS). The software provides both graphical input and output, to facilitate efficient data entry and monitoring of data. Graphical input is transformed to textual information, which is stored in a database in a hierarchical tree structure. Pain management in MS may be achieved by careful monitoring of the symptom in response to treatment. Pain location is selected on a body image and severity and other attributes represented using a graphical visual analog scale, leading to more convenient input and a less ambiguous coding than is achievable with narrative text alone. This approach could provide an objective means of monitoring the progress of the disease and management of the symptoms. The intuitive interface may also facilitate self-monitoring.

Computer Graphics↗
PubMed2001

Objective psychomotor skills assessment of experienced, junior, and novice laparoscopists with virtual reality.

Objective assessment of psychomotor skills in surgery is now a priority; however, this assessment is difficult to achieve because of measurement difficulties associated with the reliability and validity of assessing surgical skills in vivo and in the laboratory. In this study virtual reality (VR) was used to overcome these problems in the objective psychomotor assessment of senior, junior, and novice laparoscopists. Twelve experienced laparoscopic surgeons (performed >50 Minimal Access Surgery (MAS) procedures), 12 inexperienced laparoscopic surgeons (<10 MAS procedures), and 12 laparoscopic novices (no MAS procedures) participated in the study. Each subject completed all six tasks of the Minimally Invasive Surgical Trainer; Virtual Reality (MIST VR). In comparison to the other groups, experienced laparoscopic surgeons performed the tasks significantly (p < 0.01) faster, had a lower error rate, were more economic in their movement of surgical instruments and in the use of diathermy. As a group they also showed greater consistency in their performance. MIST VR distinguished between the three groups of laparoscopists. VR provides a useful objective assessment tool for evaluating psychomotor skills for laparoscopic surgery.

Adult↗
PubMed2001

Virtual reality training leads to faster adaptation to the novel psychomotor restrictions encountered by laparoscopic surgeons.

BACKGROUND: The fulcrum effect of the body wall on instrument handling poses a major obstacle to the mastery of instrument coordination for junior laparoscopic surgeons. This study evaluated three types of laparoscopic simulator training to assess their ability to promote the user's adaptation to the fulcrum effect. METHODS: Thirty-two participants with no previous experience in laparoscopic surgery were randomly assigned to one of four groups representing different training conditions. One group was assigned to use a virtual reality simulator (MIST VR); two others were given a laparoscopic Z or U maze-tracking task. The control group received no training. Subjects were asked to perform a 2-min laparoscopic cutting task under normal laparoscopic imaging conditions first before and then after training. RESULTS: In the test trial, subjects who trained on MIST VR made significantly more correct incisions (p < 0.0001) and fewer incorrect incisions (p < 0.0001). CONCLUSION: Training on a virtual reality simulator such as MIST VR helps laparoscopic novices adapt to the fulcrum effect faster.

Clinical Competence↗
PubMed2001

Self-expanding oesophageal stents: strategies for re-intervention.

BACKGROUND AND STUDY AIMS: Self-expanding metal stents have become accepted palliation for inoperable malignant oesophageal obstruction, the cost of the devices being offset against the ease of insertion and the reduced complication rate. However, re-intervention is often required for obstruction, malposition, migration and tumour progression. The marginal cost of re-stenting is generally higher than other modalities. This study aims to determine the rate of re-intervention and the effectiveness of the various intervention modalities. PATIENTS AND METHODS: A population of 165 patients, treated in a tertiary referral oesophageal centre, (132 with oesophageal cancer, 31 with mediastinal metastases from other tumours, two with benign conditions) whose initial stent placement was performed between January 1994 and December 1998 was followed-up through July 1999 or till death. RESULTS: A total of 75 re-interventions were required in 44 patients and were successful in 51 (68%). Rigid oesophagoscopy and removal of food bolus was successful in three out of three, dilation in one of 11, rigid oesophagoscopy and physical debridement in 12 of 17 and laser debridement in 12 of 20. Re-stenting was the primary re-intervention in 10 cases and was ultimately necessary in 14 patients (with 11 self-expanding metal stents, three Celestin) who had previously undergone other forms of re-intervention. It was not successful in one case. The median survival following first re-intervention was 9.8 weeks (compared with 14.3 weeks for initial stenting) and was longer in those receiving radiotherapy (23.6 weeks) or chemotherapy (14.4 weeks). CONCLUSIONS: While repeated stenting is usually successful, debridement and laser vaporization are viable alternatives for proximal tumour overgrowth or ingrowth in the upper or middle third of the oesophagus. Distal tumour growth or ingrowth at the oesophagogastric junction are best treated with a second stent. Repeated treatment is justified, as survival following first re-intervention is comparable to that after initial stenting, particularly in those patients who are able to undergo chemotherapy or radiotherapy.

Equipment Design↗
PubMed2000

A comparison between randomly alternating imaging, normal laparoscopic imaging, and virtual reality training in laparoscopic psychomotor skill acquisition.

OBJECTIVES: To evaluate virtual reality as a laparoscopic training device in helping surgeons to automate to the "fulcrum effect" by comparing it to time-matched training programs using randomly alternating images (ie, y-axis inverted and normal laparoscopic) and normal laparoscopic viewing conditions. METHODS: Twenty-four participants (16 females and 8 males), were randomly assigned to minimally invasive surgery virtual reality (MIST VR), randomly alternating (between y-axis inverted and normal laparoscopic images), and normal laparoscopic imaging condition. Participants were requested to perform a 2-minute laparoscopic cutting task before and after training. RESULTS: In the test trial participants who trained on the MIST VR performed significantly better than those in the normal laparoscopic and randomly alternating imaging conditions. CONCLUSION: The results show that virtual reality training may provide faster skill acquisition with particular reference to automation of the fulcrum effect. MIST VR provides a new way of training laparoscopic psychomotor surgical skills.

Adult↗
PubMed2000

Routine follow-up office visits after total joint replacement: do asymptomatic patients wish to comply?

A total of 100 patients presenting for routine office follow-up after total hip or knee arthroplasty completed questionnaires evaluating whether they preferred to come to the office for routine follow-up evaluation or whether they would have preferred an evaluation without an office visit. Of 100 patients, 45 would have preferred not to come into the office for a routine evaluation. They were content to mail completed questionnaires and radiographs to their physicians. The other 55 patients preferred office visits. These 2 groups were comparable for age, sex, height, weight, and number of surgeries (P > .11) Preoperative and postoperative scores were similar between the 2 groups (P > .39). None of the patients that would have preferred not to come in to the office believed that quality of care would be compromised. A significant number (45%) of patients would prefer not to come to the office because of the wages saved and time spared. Routine office visits may be eliminated for these patients through the use of health outcome devices, such as the SF-36, along with routine radiographs. The potential to decrease healthcare costs and increase patient satisfaction warrants the identification of these patients. Assessment of the effect on quality of care with elimination of routine follow-up visits requires further study.

Aged↗
PubMed2000

Randomly alternating image presentation during laparoscopic training leads to faster automation to the "fulcrum effect".

BACKGROUND AND STUDY AIMS: The aim of this study was to evaluate four training programmes intended to help laparoscopic surgeons automate to the "fulcrum effect". METHODS: A total of 32 participants (16 men, 16 women), were randomly assigned to one of four different image-viewing conditions: full binocular, y-axis inverted, normal laparoscopic and randomly alternating (between y-axis-inverted and normal laparoscopic). The subjects were requested to perform 10 trials of a simple laparoscopic cutting task, each lasting 2 minutes. Each then completed a 2-minute test under normal laparoscopic imaging conditions. RESULTS: In the final test trial, participants who trained under the randomly alternating imaging conditions (y-axis inverted and normal laparoscopic) performed significantly better than those from the other groups. CONCLUSION: Training under a randomly alternating viewing condition helps laparoscopic trainees automate to the "fulcrum effect" faster.

Adolescent↗
PubMed1999

Total thoracic oesophagectomy for oesophageal carcinoma: has it been worth it?

OBJECTIVE: Anastomotic recurrence is a major cause of late mortality following oesophago-gastrectomy (OG) for carcinoma of the oesophagus and oesophago-gastric junction using either the Ivor Lewis or left thoraco-abdominal approach with intra-thoracic anastomosis. The aim of this study was to determine whether the more extensive total thoracic oesophagectomy (TTO) with cervical anastomosis would reduce the anastomotic recurrence rate while maintaining acceptable operative morbidity and mortality. METHODS: From January 1988 to December 1996, 108 total thoracic oesophagectomies and 66 oesophago-gastrectomies were performed with curative intent in 174 patients (125 males, mean age 62.4 years) with carcinoma (squamous cell carcinoma in 34 and adenocarcinoma in 140) of the middle (31 patients) and lower (44 patients) oesophagus and oesophago-gastric junction (99 patients). RESULTS: Minor complications occurred in 37 (34%) total thoracic oesophagectomy and 18 (27%) oesophago-gastrectomy patients, major complications in 15 (14%) and 5 (8%) and peri-operative death in 5 (4.6%) and 7 (11%) patients, respectively. Anastomotic leakage occurred in 10 (9%) total thoracic oesophagectomy and 5 (8%) oesophago-gastrectomy patients, and was fatal in 1 (1%) and 4 (6%). There was no incidence of tumour at or within 5 mm of the proximal limit in the total thoracic oesophagectomy group and this was reflected in the complete absence of anastomotic recurrence. In the oesophago-gastrectomy group there was a positive proximal resection margin in 13 (20%) and 13 anastomotic recurrences (22% of peri-operative survivors). The 5-year survival (including operative mortality) was 29% for total thoracic oesophagectomy compared with 21% for the other techniques (P = 0.028 log rank test). Median survival was 25.2 months after total thoracic oesophagectomy and 15.8 after oesophago-gastrectomy. CONCLUSIONS: Total thoracic oesophagectomy can be performed in oesophageal cancer patients with comparable morbidity to that of lesser resections. Incomplete proximal resection and anastomotic recurrence did not occur in this series of 108 total thoracic oesophagectomies and this is reflected in an increased medium term survival. The improved survival is most apparent for tumours of the oesophago-gastric junction.

Adenocarcinoma↗
PubMed1999

Virtual reality training in laparoscopic surgery: a preliminary assessment of minimally invasive surgical trainer virtual reality (MIST VR).

BACKGROUND: The "fulcrum effect" of the body wall on surgical instrument manipulation is a major hurdle for novice endoscopic surgeons. Virtual reality training has not previously been evaluated as a means to overcome this problem. MATERIALS AND METHODS: 16 participants with no experience of endoscopy were required to make multiple defined incisions under laparoscopic laboratory conditions within 2-minute periods. Half of the subjects were randomized to receive initial training on the Minimally Invasive Surgical Trainer, Virtual Reality (MIST VR) computer programme. RESULTS: Participants with MIST VR training made significantly more correct incisions (P = 0.0001) than the control group on test trial 1, and even after extended practice by both groups (P = 0.0001). They were also significantly more likely to actively use both hands to perform the endoscopic evaluation task (P = 0.01). CONCLUSIONS: Virtual reality training represents a potential, viable solution for junior endoscopists, for overcoming the "fulcrum effect", in a replicable, safe learning environment which allows objective and reliable quantification of skill levels by trainers.

Adult↗
PubMed1999

Experienced laparoscopic surgeons are automated to the "fulcrum effect": an ergonomic demonstration.

BACKGROUND AND STUDY AIMS: The inversion of the normal laparoscopic image around the Y-axis has been shown to facilitate the rate of learning of a laparoscopic task in novice subjects. The aim of this study was to investigate the effect of Y-axis image inversion on the performance of experienced laparoscopic surgeons; this had not been previously investigated. METHODS: A total of 16 experienced surgeons,who had already carried out more than 50 operative laparoscopic procedures, and 16 novice participants, who had carried out no procedures, were required to make multiple defined incisions under laparoscopic laboratory conditions within ten 1-minute periods. Participants were randomly allocated to perform the task under either normal or Y-axis inverted imaging conditions (eight experienced surgeons and eight novices in each condition). RESULTS: Y-axis inversion had a significant detrimental effect on the performance of the surgeons, whilst facilitating the performance of novices. The surgeons however, adapted to the inverted condition rapidly, showing a significant improvement in performance over the ten trials. CONCLUSIONS: The Y-axis-inverted image has a detrimental effect on the performance of experienced surgeons, indicating that they have automated to the "fulcrum effect" of the abdominal wall on instrument manipulation. Y-axis-image inversion was found to facilitate significant learning trends, regardless of the participants' level of experience.

Abdomen↗
PubMed1998

Ionising radiation during internal fixation of extracapsular neck of femur fractures.

This study analyses the relationship between the level of experience of both surgeon and radiographer and the radiation dose administered in theatre, during fixation of extracapsular proximal femoral fractures. From the 63 dynamic hip screw procedures performed, 10 were done by Senior House Officers (SHOs), 10 by Consultants and 43 by Registrars, whereas Basic Radiographers were involved in all cases. Fractures were classified as two part, three part or four part. A four part fracture required higher levels of radiation dose and screening time as compared with a two part fracture. All two part fractures were screened by radiographers of similar experience; however, the radiation dose and screening time were different amongst different levels of surgeon. The highest radiation dose and screening times were recorded when an SHO was the operating surgeon and the lowest when a registrar was the surgeon. The two part and three part fractures performed by registrars were subdivided according to the experience of the radiographer. In both cases a statistically significant difference was found between the dose of radiation administered in theatre and the years of experience of the radiographers (p < 0.05).

Aged↗
PubMed1998

An ergonomic analysis of the fulcrum effect in the acquisition of endoscopic skills.

BACKGROUND: The loss of three-dimensional visual depth cues has been thought to be the main hindrance to the acquisition of endoscopic skills. However, the "fulcrum effect" of the abdominal wall on the manipulation of instruments has not to our knowledge been previously investigated. METHODS: Subjects with no experience in endoscopy were required to make multiple defined incisions under laparoscopic laboratory conditions, within ten two-minute periods in the first study and 50 in the second. Eleven subjects operated under normal imaging conditions and 11 with the y-axis inverted. RESULTS: Subjects who operated with the image inverted made significantly more incisions and significantly more correct incisions than those working under normal conditions. This effect persisted over 50 trials. CONCLUSIONS: The fulcrum effect has a major detrimental influence on acquisition of endoscopic skills. Further work is required to investigate the role of image inversion in clinical endoscopic training.

Adult↗
PubMed1998

[Extirpation of the thoracic part of the esophagus using left lateral thoracoabdominal and cervical approach].

From 1988 to 1994 year extirpation of thoracic part of the esophagus with the use of left lateral thoracoabdominal and cervical approach was carried out in 81 patients with cancer of middle (27) and lower (25) thirds of the esophagus and cardia (29). Tumor was removed en bloc with regional lymph nodes, dissected stomach was fixed to the esophageal stump and transferred to the neck, where esophago-gastral anastomosis was created by uninterrupted one-layer suture. 5 patients (6.2%) died after the operation, insufficiency of sutures of the anastomosis was detected in 5 (6.2%) patients, the fistula being spontaneously closed up. Mean duration of the operation made up 309 +/- 48 min, hospitalization 18.4 + 10.9 days. Cumulative actuarial survival rate made up: 1- years--58.9 +/- 5.7%, 3 years--26.9 +/- 6.3%, 5 years-- 20.8 +/- 6.2%. Mean duration of life after the operation was 27.8 +/- 3.4 months.

Actuarial Analysis↗
PubMed1997

Reactions to managed care among psychologists and social workers.

Although the delivery system for mental health care is undergoing unprecedented changes with managed care, few empirical assessments of practitioners' responses exist. Directories of managed care providers were used to contact 139 providers of managed mental health care for an anonymous survey of experiences with case management and short-term therapy. The differential effects of managed care on the practices of doctoral-level psychologists, master's-level psychologists, and social workers were examined.

Adult↗
PubMed1996

Self-expanding stents for malignant dysphagia.

Self-expanding metallic stents have been employed successfully for vascular, urethral, and biliary strictures. In a prospective study we examined the efficacy of the 16 mm Wallstent for palliation of malignant dysphagia. Eight patients with severe dysphagia due to advanced primary (four) or secondary (four) oesophageal malignant disease were recruited and nine Wallstents were inserted (one patient required two). Dysphagia was reduced in all but one patient, who died after oesophageal perforation; a second patient had a self-limiting bout of haematemesis. Two patients required subsequent treatment for tumour ingrowth but five had no further palliative therapy from stent insertion to time of death. With careful patient selection and skillful application, a 16 mm self-expanding metal endoprosthesis affords effective palliation in malignant oesophageal obstruction.

Adult↗