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Biomedical subjects

J McGovern

Publications and source records attributed to J McGovern.

27 records · Page 2Linked to original sources
PubMed1987

Nucleolar organiser regions in small cell carcinoma of the bronchus.

An argyrophil technique for the demonstration of nucleolar organiser regions has been applied to routinely processed paraffin sections of 15 specimens of small cell carcinoma and 15 biopsy specimens infiltrated by lymphocytes. To avoid tautological problems, the nature of the specimens was confirmed by means of immunohistochemical staining for neurone specific enolase and leucocyte common antigen. The specimens of small cell carcinoma were readily differentiated from those containing lymphocytes by the argyrophil method, the range of mean number of nucleolar organiser regions per nucleus being 4.2-7.3 for small cell carcinoma cells and 0.9-1.7 for lymphocytes. This method separates malignant epithelial cells from benign lymphocytic cells and has potential in both clinical and research investigation of respiratory tumours.

Bronchial Neoplasms↗
PubMed1985

Immunohistochemical analysis of the early ontogeny of the neuropeptide Y system in rat brain.

The distribution of neuropeptide Y in the developing rat brain was studied with immunocytochemistry, using the peroxidase-antiperoxidase method. Immunoreactive perikarya were first seen on embryonic day 13 and staining of fibres appeared from embryonic day 15 onwards: perikaryal staining was generally more intense prenatally than after birth. Areas rich in neuropeptide Y immunostaining included the monoaminergic regions of the brain stem from embryonic day 13 (especially the lateral reticular nucleus and the medullary reticular formation), the dorsal mesencephalon (with spots of immunoreactivity in the outer subventricular zone at embryonic days 13 or 14 and many cells and fibres in the inferior colliculus from embryonic days 16-20) and the olfactory tubercle/ventral striatum from embryonic day 15 until birth. The period of development of cortical neurones extended from embryonic day 19 until postnatal day 21. A hitherto unreported feature unique to neuropeptide Y was the presence in certain parts of the cerebral cortex of transient cells at the base of the cortical plate bearing radial processes which transverse its width. They were present from embryonic day 17 until postnatal day 4 and were maximally developed at embryonic days 20 or 21, contributing at this age a substantial fibre projection through the immature corpus callosum. The abundance of neuropeptide Y in the prenatal rat brain suggests it may play an important role in development.

Age Factors↗
PubMed1981

An analysis of different techniques for distal hypospadias repair: the price of perfection.

We discuss the risks of total surgical correction of distal hypospadias with chordee, review 42 such cases and analyze 4 common surgical procedures that were used. The over-all complication rate was 16.6 per cent (7 of 42), with 9.5 per cent (4 of 42) of the cases requiring addition urethral reconstruction. All complications occurred following procedures designed to extend the urethral meatus to the tip of the glans (Horton-Devine 5 of 15 and Ombrédanne 2 of 8). In contrast, no complications occurred following urethral advancement or Allen-Spence repairs (0 of 19). The physician and family should be aware of the increased risk attendant with total anatomical urethral correction in contrast to less extensive surgery, which gives an excellent functional result with minimal risk.

Adolescent↗
PubMedDate not supplied

EXTEND: a prototype expert system for teaching nursing diagnosis.

In this article, the development and uses of EXTEND (Expert system for Education in Nursing Diagnosis), a computer assisted instruction package for teaching nursing diagnosis using the categories proposed by the North American Nursing Diagnosis Association, are described. EXTEND provides a knowledge base that is able to deduce a nursing diagnosis from case factors and extends the normal use of expert systems beyond diagnosis to diagnosis education by providing answers to student questions about a simulated client and by guiding them through the diagnostic task. Furthermore, EXTEND allows the teacher to record the steps taken by students in the assessment and diagnosis of the simulated client, and use this as the focus of further discussion. The system is a response to the problems of teaching nursing diagnoses cited in the professional literature.

Computer-Assisted Instruction↗