Search PubMed⌕ Search

Biomedical subjects

J McCormick

Publications and source records attributed to J McCormick.

At least 91 records · Page 5Linked to original sources
PubMed1984

Angiotensin sensitivity and prostaglandins in dogs with renal hypertension.

During established two-kidney one clip hypertension in dogs blood pressure is elevated despite only slightly raised plasma renin activity. Dose dependent effects of exogenous angiotensin II on systemic and renal haemodynamics were examined before and after induction of this type of hypertension in conscious dogs. There was no difference in the response of blood pressure to angiotensin II in each group, suggesting that altered pressor sensitivity to angiotensin II is not the cause of the persisting hypertension. However sodium excretion, effective renal plasma flow and glomerular filtration rate were all decreased by angiotensin II in the normotensive group, but were unchanged or increased in the hypertensive group. Renal prostaglandin E excretion was also increased in the hypertensive animals, and further increased during infusion with angiotensin II. The altered renal response to angiotensin II in the hypertensive group may reflect changes in occupancy of angiotensin II receptors and/or enhanced renal release of vasodilator prostaglandins.

Angiotensin II↗
PubMed1983

Bulimia nervosa.

Explore the source record for details and available documents.

Adolescent↗
PubMed1983

Living together.

Explore the source record for details and available documents.

Humans↗
PubMed1982

Haemorrhagic fever in Gabon. I. Incidence of Lassa, Ebola and Marburg viruses in Haut-Ogooué.

A serological enquiry aimed at determining the incidence of infection with Lassa, Ebola and Marburg viruses was conducted on the human population of the region of Haut-Ogooué (Gabon) and on primates. The results, obtained by the indirect immunofluorescence technique, showed that more than 6% of the human population had had contact with Ebola virus but no antibodies against Marburg or Lassa viruses were found. Most sera reacted to an Ebola antigen from a Zairian strain, but showed little or no reaction to an antigen from a Sudanese strain.

Adult↗
PubMed1981

Effects of salt and water depletion on the early phase of hypertension in Goldblatt two-kidney hypertensive dogs.

1. Hypertension was induced in dogs by partial occlusion of one renal artery, the opposite kidney remaining intact, and the changes in blood pressure, plasma renin activity, aldosterone and prostaglandin E (PGE) were monitored. 2. Two days after induction of hypertension, the retained sodium and water were removed by haemodialysis and the animals were then maintained on a low dietary intake of sodium for the following 7 days. 3. Removal of the accumulated sodium and water had no immediate effect on blood pressure, but during the ensuring 7 days there was a small decrease in blood pressure, which again increased after re-institution of a normal sodium intake. 4. Plasma renin activity and aldosterone increased during development of hypertension and remained elevated during the period of sodium restriction. 5. Sodium and water retained during the development of hypertension was not responsible for the elevated blood pressure. 6. The concentration of PGE in arterial plasma and renal venous plasma from the unclamped kidney were unchanged during the study, although we have previously shown that in the absence of sodium depletion, PGE rises. 7. PGE released from the kidney may be important in mediating the excretion of sodium and water that is retained during the development of renal hypertension.

Aldosterone↗
PubMed1980

Pneumonitis caused by gold salt therapy: evidence for the role of cell-mediated immunity in its pathogenesis.

Gold salt-related pneumonitis is now an established clinical entity, but the mechanism for the induction of the pulmonary disease is not known. In 2 patients with this disorder, we observed elaboration of the lymphokines, migration inhibition factor (MIF) and macrophage chemotactic factor (MCF), by peripheral blood lymphocytes after incubation with gold salt. Incorporation of [3H]thymidine was not seen with several different dosages of gold salt. Control lymphocytes from normal subjects, from patients with rheumatoid arthritis but not receiving gold salt, and from patients with rheumatoid arthritis receiving gold salt but without hypersensitivity manifestations, were all unresponsive to the drug. These results suggested that the pneumonitis associated with chrysotherapy is also associated with a specific cellular immune response to the drug. Further, they point to the necessity of evaluating multiple parameters of cellular immunity, because in these patients there was a dissociation between blast transformation and mediator production. In addition, they underscored the need for further observations of cellular responsiveness in patients receiving gold salt therapy with and without overt pulmonary disease.

Female↗
PubMed1976

Classification criteria for systemic lupus erythematosus. Frequency in normal patients.

One hundred healthy women were examined prospectively during their annual physical examination for any of the preliminary criteria of systemic lupus erythematosus (SLE). No patient had more than three of the criteria; 50 (50%) had none. The preliminary criteria were effective in excluding normal patients. Three of 19 patients taking oral contraceptives had serum antinuclear antibody (ANA), whereas only one of 81 non-pill users had serum ANA (P less than .05). None of these patients with positive ANA had clinical evidence of SLE.

Adult↗
PubMed1976

The hospital pyramid.

Explore the source record for details and available documents.

Education, Medical, Graduate↗
PubMed1976

Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.

Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera.

Animals↗