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Biomedical subjects

J McCauley

Publications and source records attributed to J McCauley.

125 records · Page 7Linked to original sources
PubMed1980

Nucleotide sequences at the terminal of La Crosse virus RNAs.

The 5' and 3'-terminal sequences of the three RNA molecules which make up the genomes of La Crosse virus are reported. Eleven nucleotides at both the 5' and 3' termini of all three RNAs are conserved and complementary. In addition more extensive unique sequence complementarity is present in at least two of the three RNAs.

Base Sequence↗
PubMed1980

Structure and synthesis of influenza virus complementary RNAs.

Two classes of genome transcript are involved in the replication of influenza viruses, both of which contain molecules complementary to all eight genome RNAs. One of these classes, which comprises the viral mRNAs, consists of transcripts that have additional 5' terminal non-viral sequences including "cap" structures and 3' terminal polyadenylate sequences but which lack sequences corresponding to nucleotides 1-16 at the 5' termini of the virus RNAs. The members of the other class are complete genome transcripts with no additional sequences and these are thought to be the templates for genome replication. The syntheses of the two classes of molecules have a number of distinctive features which together with their structural properties indicate that they are synthesized by different mechanisms.

Base Sequence↗
PubMedDate not supplied

Percutaneous transluminal renal angioplasty in nonatherosclerotic renovascular hypertension. Long-term results.

Nineteen stenotic arteries in 16 patients with severe renovascular hypertension of nonatherosclerotic nature (fibromuscular dysplasia in 13, neurofibromatosis in 3) were treated with percutaneous transluminal renal angioplasty. The procedure was technically successful in 12 of 14 (86%) stenoses in the fibromuscular dysplasia subgroup but in only one of five (20%) lesions in the neurofibromatosis subgroup. Hypertension was abated (3 patients) or disappeared (8 patients) in 11 of the 12 (92%) patients with fibromuscular dysplasia who had a technically successful angioplasty, an effect that was sustained at latest follow-up (avg, 37 mo; range, 10-73 mo). The only complication encountered was a retroperitoneal hematoma that resolved uneventfully. Coupled with those from other centers, the results of the present study indicate that angioplasty offers a strong potential for curability in patients with renovascular hypertension caused by fibromuscular dysplasia and that percutaneous transluminal renal angioplasty should be considered the treatment of choice for the initial management of all patients with fibromuscular renovascular hypertension.

Adolescent↗
PubMedDate not supplied

Interviewing style and response to family information by family practice residents.

The visits of 50 new patients seeing 20 family practice residents were audiotaped. Analysis of transcripts of all conversation involving family-related content showed that the resident physicians used a high control interviewing style consisting mostly of closed-end questions and declarative statements. They rarely asked open-end questions. After eliciting family information, the residents missed numerous opportunities to express empathy or concern verbally. The physicians seldom connected family information obtained during the visit with the patient's ongoing or potential health problems. Of 12 patients reporting a life-threatening familial illness in a close relative, only one received any relevant patient education. The closed style of interviewing appeared to interfere with the physicians' gathering and responding to family information.

Family Practice↗