Caloric expenditure in cold-acclimating rats: an isogravimetric comparison.
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Biomedical subjects
Publications and source records attributed to J Mayer.
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No anatomical connections have yet been demonstrated from the ventromedial ("satiety") to the lateral ("feeding") areas of the hypothalamus. Lesions were induced with goldthioglucose in mice in the ventromedial region, including the arcuate and ventromedial nuclei. With the Fink-Heimer stain for degenerating axons, fiber connections between these two areas were demonstrated.
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This is not the place to consider the medical significance of obesity in terms of conditions such as heart disease and hypertension, diabetes, and arthritis. These very complex interrelationships have been dealt with elsewhere (69). We hope that enough evidence has been presented to demonstrate that energy balance is normally maintained by a precise and reliable physiologic mechanism, and that the energy surplus represented by obesity may reflect direct failure of this mechanism or some combination from a variety of neurological, endocrine, enzymatic, and psychological disorders. Environmental conditions as well as genetic and traumatic factors may contribute to the development of obesity. If increasing mechanization brings tus below the level of energy expenditure at which food intake is properly regulated, appropriate habits of exercise will have to be established and maintained.
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