[Effective suicide prevention telephone service. Voluntary workers needed].
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Crisis Intervention↗
Biomedical subjects
J Mattila
Publications and source records attributed to J Mattila.
Concentrations of metronidazole and tinidazole in female reproductive organs after a single intravenous infusion and after repeated oral administration.
Concentrations of metronidazole and tinidazole in serum and gynecological organs were analyzed after a single 500 mg intravenous infusion and after three days of treatment with 400 mg t.i.d. of metronidazole or 500 mg b.i.d. of tinidazole. The studies were performed in 67 patients subjected to hysterectomy and/or oophorectomy because of myomatosis uteri, carcinoma uteri or endometriosis. At the time of organ removal (about 30 min after infusion), metronidazole and tinidazole levels in serum were 14.5 +/- 0.45 mg/l and 12.3 +/- 0.38 mg/l, respectively. Concentrations of both drugs in the uterus and Fallopian tube were about the same as the simultaneous serum levels and concentrations in the ovaries about 55% thereof. At steady-state, the concentrations of tinidazole in serum (23.5 +/- 1.0 mg/l) were remarkably higher than those of metronidazole (13.5 +/- 0.84 mg/l) about three hours after the last oral dose. Drug concentrations in organs of the female reproductive tract were 70 to 100% those of the simultaneous serum levels.
Administration, Oral↗
Pharmacokinetics of sustained-release verapamil after a single administration and at steady state.
Pharmacokinetics of conventional 80 mg tablets and two types of sustained-release (SR) tablets containing 120 and 200 mg of verapamil were compared cross-over in 12 healthy volunteers. Serum concentrations of verapamil and norverapamil were analyzed both after a single oral dose and at steady state after t.i.d. administration of conventional tablets and b.i.d. administration of SR tablets. After 120 mg SR tablets serum concentrations of verapamil usually remained below 100 ng/ml for 5 days. This inadequate bioavailability was caused by very slow absorption. The relative bioavailability of verapamil in 200 mg SR tablets was 93-96% as compared to the conventional tablets. After 200 mg X 2 and 80 mg X 3, the peak serum levels were about 300 and 190 ng/ml, respectively and the trough levels 123-153 and 52-56 ng/ml, respectively. The verapamil/norverapamil ratio varied from 0.69 to 0.84 after a single dose and from 0.8 to 0.93 at steady-state. By the 4th days of treatment, the accumulation ratios ranged between 1.75-2.07 and 1.30-1.75 for verapamil and norverapamil, respectively. For each preparation studied, the apparent Cltot of verapamil was significantly reduced at steady-state. These results show that 200 mg SR verapamil tablets fulfill the basic requirements of retard preparations allowing for twice or even once daily administration.
Adult↗
Is "indeterminate colitis" Crohn's disease in the long-term follow-up?
The diagnosis of "indeterminate colitis" was found in 6 patients of 147 operated patients (4%) as compared to the indeterminate diagnosis in 59 of 465 non-operated colitis patients (13%) at the register of inflammatory bowel diseases of Tampere University Hospital. The long-term natural course of the six surgically treated "indeterminate colitis" patients was analysed. The term "indeterminate colitis" included macroscopically either Crohn's colitis or ulcerative colitis which histologically remained indeterminate both pre and peroperatively. Clinicopathological follow-up after the median 5 1/2 years indicated typical Crohn's disease in one case and probable in two cases. However, the final diagnosis remained indeterminate in three cases. The results of the present study showed that patients with indeterminate colitis may have a tendency for Crohn's colitis in the long-term follow-up and thus should be considered when planning an ileal pouch-anal anastomosis.
Abscess↗