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Biomedical subjects

J Mattes

Publications and source records attributed to J Mattes.

32 records · Page 2Linked to original sources
PubMed1993

Efficacy and safety of b.i.d. doses of venlafaxine in a dose-response study.

In this study, 312 depressed outpatients received either placebo or one of three venlafaxine doses twice daily (b.i.d.) for up to 6 weeks. The total daily doses of venlafaxine were 25, 50-75, and 150-200 mg/day. Hamilton Rating Scale for Depression (HAM-D) and Montgomery-Asberg Depression Rating Scale (MADRS) total scores at Week 6 were significantly lower for the high-dose group than for the placebo group. A positive dose-response trend for the primary efficacy parameters was demonstrated as early as Week 1. Venlafaxine was well tolerated at all dose levels. The most common side effects of clinical interest were nausea and dry mouth. The frequency of nausea in the venlafaxine groups was essentially the same (25-29%), whereas the frequencies of dry mouth, somnolence, and sweating were dose related. The results indicate that b.i.d. doses of venlafaxine are safe and effective in treating depression.

Adolescent↗
PubMed1990

A double-blind comparison of fluvoxamine, desipramine and placebo in outpatients with depression.

1. The efficacy of fluvoxamine is compared to that of desipramine in a multicenter double blind placebo controlled six-week flexible dose trial of 90 outpatients with major depressive disorder. 2. Although overall drug effects were relatively weak, there were trends suggesting separation of both active drugs from placebo at week six. Both drugs were well tolerated. 3. Studies of major depression ought to be designed to last 8-10 weeks in order to demonstrate placebo active drug differences and the stability of such a difference should it occur in the first six weeks.

Adult↗
PubMed1986

Predictors of benefit from art, movement, and poetry therapy: a pilot study.

No validated criteria exist for assigning patients to the creative arts therapies. This paper reports on a pilot study attempting to identify predictors of benefit from art, movement, and poetry therapy. Based on a priori hypotheses, selected psychological tests were administered to 31 patients who each received all three modalities of treatment. The relationships of these test scores and therapist prediction of benefit ratings to outcome were then evaluated statistically; outcome was measured by patient ratings and figure drawings. Results showed few significant predictors, though several findings requiring confirmation may provide a framework for future research. Implications and possible explanations of these results, as well as design and other research issues relevant to further work in this area, are discussed.

Art Therapy↗