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Biomedical subjects

J Massey

Publications and source records attributed to J Massey.

At least 37 records · Page 2Linked to original sources
PubMed1981

Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis.

Metabolically inert L-[1-14C]glucosylceramide is stored predominantly in the liver after intravenous administration to mice. The half-time of this glycolipid analogue in the liver is 3.5 days and its clearance occurs predominantly via the bile. Within the limited number of Gaucher specimens available for examination very high levels of glucosylceramide were found in the bile of one patient and in the liver of two patients with biliary obstruction. The question of a possible relationship between biliary excretion of glycolipid and the pathogenesis of Gaucher's disease will require further studies.

Animals↗
PubMed1981

Disopyramide and neuromuscular transmission.

The effect of disopyramide on neuromuscular transmission has been studied using the rat isolated phrenic nerve-diaphragm preparation. The response of the muscle to indirect nerve stimulation was decreased in the presence of disopyramide 5.6 x 10(-6) mol litre-1 (P less than 0.05), total blockade occurring at 5.6 x 10(-4) mol litre-1. Marked augmentation of the response to direct muscle stimulation was recorded in the presence of disopyramide 1.8 x 10(-4)-5.6 x 10(-4) mol litre-1. Disopyramide 5.6 x 10(-6) mol litre-1 caused a leftward shift of the log concentration response for tubocurarine and decreased the antagonist effect of neostigmine.

Animals↗
PubMed1980

Migraine.

Explore the source record for details and available documents.

Cerebral Infarction↗
PubMed1975

Low-dose heparin prophylaxis against fatal pulmonary embolism.

A prospective randomised controlled trial in 500 patients over the age of 50 who were undergoing major surgery showed that low-dose subcutaneous heparin was an effective prophylactic measure against fatal pulmonary embolism. None of the 252 patients who received perioperative heparin cover died of fatal pulmonary embolism while eight of the 236 who did not receive heparin prophylaxis died of fatal pulmonary embolism. These results were statiscally significant (P less than 0.01).

Aged↗