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J Marx

Publications and source records attributed to J Marx.

206 records · Page 12Linked to original sources
PubMedDate not supplied

Severe acid-base abnormalities associated with cocaine abuse.

Severe acid-base disorders accompanying cocaine abuse have been reported but not emphasized in the literature. We report three cases of cocaine toxicity associated with profound acid-base derangements. Two cases demonstrated severe metabolic acidosis, one of which was not associated with known seizure activity. In addition, one case of profound alkalosis associated with cocaine use is presented. These cases are reported to emphasize the marked acid-base changes that can occur as a result of cocaine toxicity.

Acid-Base Imbalance↗
PubMedDate not supplied

Detection of villous conidia of Conidiobolus coronatus in a blood sample by scanning electron microscopy investigation.

Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules develop that are attached to the underlying tissues but not to the skin. No morphological studies are available in the literature on the morphology of C. coronatus in vivo and all morphological studies have been conducted on in vitro cultures. Here the authors report on the ultrastructural pathology as seen with a scanning electron microscope (SEM) of villous conidia of C. coronatus, detected in a 37-year-old woman who presented to the casualty department at Pretoria Academic Hospital, South Africa with left-sided facial pain and headache. The diagnosis of C. coronatus was confirmed by LightCycler real-time flourescence PCR technique. Research shows that typically diagnosis of the pathogen is established only on histological examination, and in over 85% of cases cultures for the causative organism is negative. This pathogen has not previously been found in a blood sample and the authors present for the first time the morphology of C. coronatus in blood using the SEM.

Adult↗
PubMedDate not supplied

Structural changes in the fibrin network of a pretoria family with dysfibrinogenemia: a scanning electron microscopical study.

Inborn errors of fibrinogen structure are by definition congenital dysfibrinogenemias. The present study assesses the scanning electron microscope characteristics in the fibrin network morphology in a Pretoria family with an amino-acid substitution defect at position 139 on the gamma chain where the cystein residue is replaced by tyrosine. This anomaly results in a disturbance of the interchain disulfide bond, an ultrastructural defect that interferes with fibrin polymerization. Clinical manifestations showed that 2 of the family members presented with thrombosis, as well as a bleeding tendency, while 2 were asymptomatic. Fibrin clot analysis revealed that in all 4 family members a tighter fibrin network with increased fibrin density and reduced pore size was present. The fibers showed a "stellate" appearance where they converge and some were fused longitudinally to form sheets of "matted" fibrin. Furthermore, there was a conspicuous absence of platelets. Fibrin dysfunction is associated with the development of vascular complications, while proneness to the formation of tight and rigid fibrin networks is independently associated with thrombotic disease. Although this does not explain the proneness of some family members who present with excess bleeding, bleeding might be related to the defective binding of fibrin to activated platelets, resulting in inadequate prothrombotic stimulus that is normally enhanced by the second wave of thrombin generation, which occurs on the platelet surface.

Afibrinogenemia↗
PubMedDate not supplied

Ultrastructural investigation of Zimmermann-Laband syndrome.

Zimmermann-Laband syndrome (ZLS) is a very rare autosomal dominant inherited condition characterized by 3 major clinical findings of which gingival hyperplasia are always present. The great heterogenicity of the syndrome is illustrated by the numerous variable clinical findings described in the literature. The purpose of the study was to examine a patient diagnosed with ZLS and to describe possible new characteristics of this rare syndrome, including the ultrastructural morphology using a transmission electron microscope (TEM) of the gingival and dermal fibroblasts. The ultrastrucutral morphology as has not previously been described in the literature. Tissue was collected from the alveolar ridge and skin of the forearm for TEM. TEM studies indicated the presence of prominent fibroblasts situated among numerous regular dense connective tissue bundles. Genetic analysis showed a new chromosomal insertion, ins(12;8)(p11.2;q11.2q24.3), suggesting that the gene responsible for the syndrome lies on chromosome 8.

Abnormalities, Multiple↗
PubMedDate not supplied

Genital infections with herpes simplex virus in a university student population.

The frequency of clinically evident genital infections with herpes simplex virus among students attending a large urban public university was studied. One-hundred ninety-eight students experienced 222 episodes of this disease over a one-year period. The mean age of the students, both undergraduate and graduate, with the diagnosis of genital herpes ranged from 23.6 years for those with a single initial episode to 24.9 years for those with recurrent episodes. The male-to-female ratio and socioeconomic class of students with genital herpes were not significantly different from those of the general university population. The incidences of both initial and recurrent episodes of genital herpes were statistically significantly higher during the months of July through October (with the exception of September). Genital herpes was a frequently diagnosed sexually transmitted disease among this student population.

Adult↗
PubMedDate not supplied

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History, Modern 1601-↗