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Biomedical subjects

J Marsh

Publications and source records attributed to J Marsh.

138 records · Page 8Linked to original sources
PubMed1978

Biologic half-life and organ distribution of radiolabeled human PiM and PiZ alpha-1-antitrypsin in the dog.

Highly purified A-1-A.T., prepared from blood obtained from donors of known PiZZ and PiMM phenotype, was radiolabeled with 125I or 131I and injected intravenously into dogs. The radiolabeled proteins retained their prelabel electrophoretic and trypsin-inhibitory characteristics. The biologic t1/2 of both M and Z protein in the circulation were similar, averaging 71 hr for M protein and 80 hr for Z protein. The label was shown to remain tightly bound in vivo for 2 days after injection. The material was nonpyrogenic in rabbit and dog. No arteriovenous differences in radioactivity could be detected at 2 or 20 min after injection. However, surface scanning disclosed substantial pulmonary deposition of radioactivity for the first 9 hr after injection. At 48 hr, intense radioactivity was present in the spleen, but not in the liver. These studies indicate the feasibility of similar studies in man, including noninvasive assessment of body distribution of M and Z protein by surface scanning techniques.

Animals↗
PubMed1978

Phase II study of vinblastine, methyl-CCNU, and medroxyprogesterone in advanced renal cell cancer.

One hundred and sixty-five patients with advanced renal cell cancer were evaluable for combination or single-agent therapy with methyl-CCNU, vinblastine, and medroxyprogesterone. A low order or response was observed, and these agents were not proven effective as treatment for metastatic renal cell cancer. Performance status and a relatively long symptom-free interval from primary tumor to metastatic disease were found to be the most prognostically significant factors for survival.

Adenocarcinoma↗
PubMed1975

Acute perforated duodenal ulcer. An evaluation of surgical management.

The surgical management of acute perforated duodenal ulcer has been evaluated in 360 patients. Simple closure was done in 254 patients, with a mortality of 6.7%, a morbidity of 21%, and an average hospital stay of 11.9 days. In 106 patients (29%) who underwent definitive operation for treatment of duodenal ulcer disease at time of perforation, the mortality was 2.8%, the morbidity was 15%, and the average hospital stay was nine days. Follow-up studies of simple closure in patients with no previous ulcer symptoms showed that 72% of the patients remained asymptomatic; in patients with previous ulcer symptoms, only 23% were asymptomatic. Definitive operation for acute perforation is indicated in good-risk patients who have a history of ulcers. Parietal cell vagotomy and simple closure was used in four patients with excellent early results.

Adult↗
PubMed1975

One hundred consecutive operations for diverticulitis of the colon.

This report describes 100 consecutive patients treated surgically for diverticulitis of the colon. The main indications for operation were recurrent attacks (33), rapid progressive symptoms (17), bleeding (16), palpable mass (14), or combinations of the above. Eighty-four patients had primary resection (two deaths), ten had staged procedure (two deaths), and six had Hartmann procedures (one death). The mortality was highest in staged procedures as this group of patients included those with complications resulting in the greatest operative risks. No deaths occurred in the elective cases. In 25 cases, various complications developed. The most common was wound infection and sepsis. The five deaths in the series are reported in detail with an evaluation of possible alternative methods of treatment. Follow-up of the series showed only one recurrence in the two years after operation.

Adult↗
PubMed1975

Thymoma and systemic lupus erythematosus.

The simultaneous occurrence of a thymoma and systemic lupus erythematosus (SLE) is reported. Disease state associated with thymoma are reviewed and the possible immunological basis for this spectrum of diseases is discussed. The role of angiography in the diagnosis of thymic tumours is described.

Humans↗