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Biomedical subjects

J Markowski

Publications and source records attributed to J Markowski.

33 records · Page 2Linked to original sources
PubMed1994

Antibiotic prophylaxis for urodynamic testing in patients with spinal cord injury: a preliminary study.

This study was performed in order to: (i) determine the incidence of symptomatic urinary tract infection (UTI) in patients with spinal cord injury after urodynamic testing; (ii) evaluate the role of antibiotic prophylaxis for such a procedure; and (iii) investigate whether pre-existing bacteriuria predisposes to the development of symptomatic UTI after urodynamic testing. Forty patients were prospectively randomized in a double-blind fashion to receive a 3-day oral course of either ciprofloxacin (18 patients) or placebo (22 patients), beginning 2 days prior to the urodynamic procedure. None of 18 (0%) patients who received ciprofloxacin developed symptomatic UTI within 5 days after the procedure compared with three of 22 (14%) subjects randomized to the placebo group; the protective efficacy of antibiotic prophylaxis, however, did not attain statistical significance (P = 0.24). None of the three bacterial isolates that were responsible for symptomatic infection were grown in corresponding urine cultures prior to the procedure. These findings may serve as a pilot for a larger study.

Adult↗
PubMed1993

Progression from asymptomatic to symptomatic urinary tract infection in patients with SCI: a preliminary study.

The purpose of this prospective pilot study was to (1) evaluate the role of pyuria in predicting the progression from asymptomatic to symptomatic urinary tract infection (UTI) in spinal cord-injured patients who undergo sterile intermittent bladder catheterization and (2) evaluate the impact of treating asymptomatic UTI on this progression. Twenty hospitalized patients were randomized to either the treatment group (10 subjects) or the control group (10 subjects). Weekly urine samples were obtained for quantitation of bacterial growth and pyuria. Neither the level nor the trend of pyuria helped predict the imminent progression to symptomatic UTI. Thirty percent of patients in the treatment group developed symptomatic UTI vs 70 percent of patients in the control group; it took a significantly longer time for patients in the treatment vs control group to develop symptomatic UTI (median number of days: 72 vs 7, respectively; p < 0.003). Further analysis of the long-term impact of antibiotic treatment of asymptomatic UTI is warranted.

Adult↗
PubMed1993

[A case of giant size lipoma of the submental region].

The authors described a case of giant size tumor of the submental region in a 53 year old patient. The very large tumor (fig. 1, 2, 3) was treated by total extirpation. Histological investigation had shown structure of lipoma.

Female↗
PubMed1992

[Septal fascioplasty as the method of surgical treatment of nose bleeding in patients with Rendu-Osler-Weber disease].

The authors describe an own method of surgical treatment of nosebleed caused by Rendu-Osler-Weber's disease. For closure of nasal septal defects we used free graft of fascia lata. In five patients treated by our method, the transplantation ended successful; during the several weeks after operations the fascia lata was covered with epithelium growing from the surrounding tissues. Control examinations did not demonstrate recurrences. In two patients our method was unsuccessful.

Epistaxis↗
PubMed1992

[Evaluation of frequency of recurrence in malignant head and neck neoplasms in the years 1980-1990].

During the years 1980-1990 in the Otolaryngological Department of the Silesian Medical Academy in Katowice 452 patients with malignant neoplasms of the head and neck were treated. 154 (35%) patients treated by radiotherapy. 140 (30%) were operated, 133 (29%) were treated by both methods and 25 (6%) were treated symptomatically. 139 (30%) out of them have had the recurrencies after the treatment. The authors made the analysis of frequency of recurrencies in years 1980-86 in comparison with period 1987-90. The statistically significant increase of frequency of recurrencies in years 1987-1990 was found.

Adolescent↗
PubMed1991

Eradication of colonization by methicillin-resistant Staphylococcus aureus by using oral minocycline-rifampin and topical mupirocin.

In an attempt to control the spread of methicillin-resistant Staphylococcus aureus (MRSA) within a spinal cord injury unit, we investigated the mode of transmission and implemented a multidisciplinary approach for control that consisted of grouping of patients into cohorts, contact isolation, and antibiotics. Surveillance cultures of patients and nose and hand cultures of medical personnel were performed. Of 11 colonized patients, 6 had MRSA isolates that shared a similar plasmid profile and antibiogram, raising the possibility of interpatient spread of the organism. Medical personnel had no evident role in transmitting MRSA. All patients' pretherapy MRSA isolates were susceptible to minocycline and, except for one, to rifampin. Time-kill studies showed an indifferent interaction of these two antibiotics. Ten colonized patients received a 2-week oral course of 100 mg of minocycline twice daily and 600 mg of rifampin once daily, while the 11th patient was treated for only 1 week. Patients with colonization of the nares also had twice daily nasal application of 2% mupirocin for 5 days. Colonization with MRSA cleared in 10 of 11 patients (91%) and 20 of 21 sites (95%). When the individual circumstances of a medical facility justify eradication of MRSA colonization, a multidisciplinary approach that includes antibiotic therapy with oral minocycline and rifampin, along with topical mupirocin for those with nasal carriage, may be successful.

Administration, Oral↗
PubMed1990

Galvanic couples of 316L steel with Ti and ion plated Ti and TiN coatings in Ringer's solutions.

Steel 316L was coated with titanium or titanium nitride by ion plating. The tightness of the coatings was examined electro-chemically. The galvanic effects for the galvanic couples steel-titanium, steel-titanium-coated steel and steel-titanium nitride-coated steel were studied. It was found that both titanium and titanium nitride coatings were non-porous in Ringer's solution; titanium served as an anode in the couple steel-titanium; it was oxidized according to the logarithmic law. For the other two couples, the coatings were the cathodes. The rate of dissolution of steel in these couples, was however, smaller than expected, owing to a strong polarization of the coatings. The potential of the couple was similar to that of steel.

Corrosion↗
PubMed1988

[Not Available].

Explore the source record for details and available documents.

General Surgery↗
PubMed1987

Differences between trunk heat patterns shown by complete and incomplete spinal cord injured veterans.

Thermograms showing heat patterns in the trunk of the body were taken of ten intact subjects, seven subjects with incomplete spinal cord injuries (SCI), and fifteen subjects diagnosed as having complete SCIs. Fourteen of the subjects with complete SCIs had a thermal demarcation line across the trunk. This line represented a temperature gradient of one to 2.5 degrees Celsius between a relatively warm upper level where sensations were normal and a relatively cool lower level in which sensations were either absent or different from pre-injury sensations. The transition zone was narrow and sharp for ten of the complete SCI subjects but was wide and gradual for the other five complete SCI subjects. The shape and width of the thermal transition zone corresponded to the location and degree of abruptness with which sensations changed from normal to abnormal. One of the subjects diagnosed as having a complete SCI failed to show a significant transition zone. The temperature difference between the upper and lower portions of his trunk was less than one degree Celsius. None of the intact or incomplete SCI subjects produced the transition zone. Only one incomplete SCI subject showed even a minimal difference in temperature between the normal sensation and abnormal sensation levels. A panel blind to the subjects' conditions was unable to differentiate between intact and incomplete SCI subjects but was able to sort complete from incomplete SCI subjects in all but the case with an indistinct transition zone.

Body Temperature↗
PubMed1986

Relationships between near surface blood flow and altered sensations among spinal cord injured veterans.

Ten patients with clinical diagnoses of complete transverse spinal cord tissue destruction were interviewed about any sensations they felt below the level at which normal feelings were evident. All ten reported experiencing various feelings most of the time and nine reported that some of those feelings were usually quite painful. Videothermographs showing differences in skin temperature of 0.1 degrees celsius were taken to evaluate blood flow patterns to a depth of 1.5 cm. Changes in blood flow patterns were found to correlate highly with the level at which sensations changed from normal to abnormal and to correlate virtually exactly with the locations of pain reported from supposedly desenate areas.

Accidents, Traffic↗
PubMed1981

Lymphedema incidence after specific postmastectomy therapy.

In a retrospective study the incidence of lymphedema was analyzed in 58 women, ages 35 to 81 years, who had received a specific treatment program after radical or modified radical mastectomy for breast carcinoma in a county hospital. Thirty-nine percent (23 patients) had cobalt treatment and 48% (28 patients) had delayed wound healing. Circumferential measurements of both upper limbs were obtained at specific corresponding sites. At the end of the 12 months, 69% of the patients had no lymphedema, 22.4% had slight lymphedema, 5.2% had moderate lymphedema and 3.4% had severe lymphedema. The benefits of close follow-up and specific treatment of mastectomized patients are evidenced in this study by the relatively large group of patients which was free of lymphedema over an extended period of time in spite of wound healing complications.

Adult↗
PubMedDate not supplied

Increased norepinephrine levels during catheterization in patients with spinal cord injury.

The hypothesis for this study was that catecholamine levels increase during urinary catheterization in human patients with spinal cord injury. Catecholamine levels, blood pressure, and pulse were measured prospectively in 40 subjects at baseline and during urinary catheterization. Results showed a significant increase in norepinephrine levels from baseline 245 +/- 240 pg (standard deviation (SD)) to 314 +/- 311 pg (SD) during catheterization (P = 0.018, Wilcoxon's). Results also showed a nonsignificant increase in epinephrine levels from baseline (56 +/- 70 pg, SD) to catheterization (84 +/- 125 pg, SD; P = 0.35, Wilcoxon's). Systolic blood pressure increased from 114 to 124 mm Hg (P = 0.004, paired t test). Diastolic blood pressure increased from 75 to 78 mm Hg (P = 0.11, paired t test). There was no significant change in diastolic blood pressure or pulse (P = 0.11 and P = 0.29, respectively, paired t test). In conclusion, norepinephrine levels increased during catheterization in patients with spinal cord injury. Knowledge of catecholamine levels in this process may assist in determining both pathophysiology and potential pharmacologic treatment options in future studies.

Adult↗