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Biomedical subjects

J Mark

Publications and source records attributed to J Mark.

At least 145 records · Page 8Linked to original sources

Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.

Chromosomes of induced carcinomas in the oral mucosa and epidermis of rats were studied in vitro. The tumours were induced by repeated applications of one of two carcinogens: the fat-soluble 7,12-dimethylbenz (a) anthracene (DMBA) or the water-soluble 4-nitrochinoline N-oxide (4NQO). Non-random chromosomal patterns, different for each carcinogen, were revealed, irrespective of the location of the tumour. The DMBA-induced carcinomas showed the same karyotypic deviations as those in leukemias and sarcomas induced in the rat by the same carcinogen. The 4NQO-induced carcinomas displayed chromosome features similar to those previously observed in embryonic rat tissue subjected to malignant transformation by the same agent.

4-Nitroquinoline-1-oxide↗

Tumor etiology and chromosome pattern.

Fibrosarcomas induced in Chinese hamsters and rats by Rous sarcomla virus and 7,12-dimethylbenz(a)anthracene are associated with nonrandom chromosome variation. Although histologically indistinguishable, the tumors induced by the virus or chemical in each host species are characterized by completely different karyotypic patterns.

Animals↗