Biomedical subjects

J Mark

Publications and source records attributed to J Mark.

203 records · Page 12Linked to original sources

PubMedDate not supplied

Cytogenetical observations and hormone receptor expression in five extra-uterine leiomyomas.

The chromosomes were studied by an in vitro technique in four parametrial and one gastric leiomyomas. The findings in parametrial myomas (the present four cases and one published earlier) differed from the observations in uterine cases by the absence of normal stemlines and the absence of 1p,6p and 7q changes. As has been shown earlier for intraocular melanomas, the location within an organ or organ system could be the explanation for the chromosomal differences. The scanty data for leiomyomas in the digestive tract (the present case and two in the literature) suggest evolutionary patterns different from those in myomas in the genital tract. The reasons for this are unknown but differences in hormonal sensitivity, as reflected by estrogen and progesterone receptor expression, might at least be a contributory factory.

Adult↗

PubMedDate not supplied

Cytogenetical observations in nine ocular malignant melanomas.

The cytogenetical findings in one conjunctival and eight uveal melanomas are reported. Six of the intraocular tumors displayed clonal abnormalities. In two of these cases there were both extensive numerical and structural aberrations. Only the single ciliary body melanoma showed the deviations monosomy 3 and gain of 8q considered typical of uveal melanomas. No preferential pattern could be discerned for the clonal abnormalities in the other uveal melanomas. The one conjunctival tumor, arising in an area of precancerous melanosis, showed only a small clone with a 4q+marker. The clonal abnormalities in the nine cases showed no similarities to those on record for cutaneous melanomas.

Aged↗

PubMedDate not supplied

Complex chromosomal changes in a primary squamous carcinoma of the parotid gland.

The chromosomal observations in a cultured primary epidermoid carcinoma of the parotid gland are reported. The tumour had a flat hyper-triploid mode with 7 recurrent wholly or partially identified marker types and 7-13 additional, mostly recurrent, markers, whose origin could not be clarified. There were also many recurring numerical deviations in most tumour cells. The picture was consistent with a neoplasma in an advanced stage of chromosomal progression. So far, 6q-markers with varying morphology are the only deviations found in most types of malignant salivary tumours and, in particular, in a high percentage of adenoid-cystic carcinomas. One possible explanation for these observations is the occurrence of one or more suppressor genes in 6q which may have relevance for malignant neoplasia in salivary gland tissues.

Carcinoma, Squamous Cell↗

PubMedDate not supplied

Cytogenetical observations in a cultured polymorphous low-grade adenocarcinoma originating from the minor salivary glands.

The cytogenetical findings in a cultured polymorphous low-grade adenocarcinoma (PLGA) of the minor salivary glands are reported. The deviations observed showed similarities to those found in the only hitherto studied case originating in the minor glands. Both these cases, however, showed a picture completely different from that in the two reported cases of parotid PLGA, constituting the malignant component in carcinomas ex pleomorphic adenoma. The most probably reasons are believed to be aetiological differences.

Adenocarcinoma↗

PubMedDate not supplied

Cytogenetics of parametrial leiomyoma.

The cytogenetical findings from a parametrial leiomyoma are presented. The results, together with those of five previously presented cases, show obvious differences when compared to the chromosomal findings in uterine myomas. Ontogenic factors are proposed to be causative for the cytogenetical differences.

Aged↗