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Biomedical subjects

J Margraf

Publications and source records attributed to J Margraf.

At least 19 recordsLinked to original sources
PubMed2000

[Are eight-year olds already suffering from panic disorder? Investigation of prevalence with focus on panic disorder and agoraphobia].

A representative sample of 826 eight-year-old second-graders in Dresden was examined in a two-stage procedure to ascertain the 6-month prevalence of DSM-IV anxiety disorders. Particular care was taken to assess panic disorder. The eight-year-olds had already been interviewed personally in a screening session and in 230 children an individual diagnostic examination with a structured diagnostic interview was carried out. The total prevalence of anxiety disorder was 9.5%. No case of either panic disorder or agoraphobia was found. For the diagnosis of agoraphobia the DSM-IV diagnostic criterion was lacking in which situations typical to agoraphobia are feared or avoided because escape would be difficult or it would be difficult to reach help. Eight-year-olds do not forge this cognitive link. In agoraphobic situations 2.5% of the children (almost exclusively, girls) suffer from a specific phobia. The prevalence of anxiety disorders is markedly higher among girls than in boys.

Agoraphobia↗
PubMed2000

[Anxiety and depression in students. A study in Dresden middle schools and high schools].

OBJECTIVES: Recent investigations by the WHO have shown once again the high prevalence of mental disorders in European countries. Mainly in the field of mental disorders considerable deficits exist particularly with regard to primary prevention. METHODS: Although there is no doubt as to the importance of primary prevention within the scope of Public Health, there are deficits in this branch in Germany. This is unfortunate, considering that the proof of successful interventions is evidence for causal risk models. The current investigation is part of a study focusing upon the development, implementation and evaluation of a prevention program for anxiety and depression in adolescents and young adults. RESULTS: Presented here are the prevalence rates of anxiety disorders and depression ascertained in the first cross-sectional study carried out in secondary schools and high schools. A total of 627 high school students and 485 secondary school students in grades nine and ten in Dresden were examined.

Adolescent↗
PubMed2000

[Separation anxiety and agoraphobia in 8-year-old children].

In the literature on the aetiology of panic disorder, the separation-anxiety-hypothesis is discussed, in which separation anxiety disorder is conceived as a precursor of panic disorder. Using the representative sample of the Dresden Child Anxiety Study (DKAS) we examined weather agoraphobic and separation anxiety symptoms do already co-occur systematically in eight-year-olds. After N = 826 children had been screened, N = 230 took part in an individual diagnostic interview. With a total prevalence of 9.5% for all anxiety disorders, the prevalence rate for separation anxiety amounted to 2.8%. Another 2.5% of the children (almost exclusively girls) received a diagnosis of specific phobia in agoraphobic situations. Separation anxiety, social anxiety, agoraphobic anxiety and panic anxiety were assessed on a dimensional level, as well. However, no specific pattern of co-morbidity could be found in terms of an increased frequency of agoraphobic fears and separation anxiety occurring simultaneously. The symptom profiles of children with separation anxiety and those with agoraphobic anxieties differed considerably. Children currently living in a separation situation do not exhibit separation anxiety or agoraphobia more frequently than the rest of the children.

Agoraphobia↗
PubMed1999

Explicit memory in anxiety disorders.

Two experiments were conducted to study selective memory bias favoring anxiety-relevant materials in patients with anxiety disorders. In the 1st experiment, 32 patients with generalized anxiety disorder (GAD), 30 with social phobia (speaking anxiety), and 31 control participants incidentally learned GAD-relevant words, speech anxiety-relevant words, strongly pleasant words, and words with a neutral valence. Participants did not show any explicit memory bias for threatening materials. Thirty patients suffering from panic disorder (PD) with agoraphobia and 30 controls took part in the 2nd experiment. The design was similar to the 1st experiment. This time a highly specific selective memory bias for threatening words was found. Words describing symptoms of anxiety were better recalled by PD patients. Results are consistent with previous findings but are inexplicable by existing theories.

Adult↗
PubMed1998

Cognitive aspects of hypochondriasis and the somatization syndrome.

The aim of this study was to evaluate whether specific cognitive aspects are present in patients suffering from somatoform disorders. With a sample of 493 patients from a center for behavioral medicine, the authors evaluated a questionnaire assessing typical cognitions concerning body perception, illness behavior, and health. The authors further examined 225 participants, including patients with a somatization syndrome, patients with somatization syndrome and additional hypochondriasis, patients with hypochondriasis, patients with other mental disorders (clinical control group), and nonclinical controls. The results showed that not only patients with hypochondriasis but also patients with somatization syndrome had cognitive concerns and assumptions that were specific for the disorder. These patients had a self-concept of being weak and unable to tolerate stress. A catastrophizing interpretation of minor bodily complaints found in hypochondriacal patients in earlier studies was also found for patients with multiple somatization symptoms.

Adult↗
PubMed1998

Psychopathology in children of patients with panic disorder or animal phobia.

Several studies reveal a heightened risk for anxiety and other mental disorders in the offspring of patients with panic disorder and other anxiety disorders. Data on the specific type of transmitted disorders, however, are inconsistent. We investigated the specificity of the relationship between parents' and children's psychopathology. We assessed current and past mental disorders in 5- to 15-year-old children of patients with panic disorder (CPAN, n = 34), children of parents with no diagnosis of a mental disorder (CCON, n = 30) and children of animal phobics (CPHOB, n = 23) using a structured diagnostic interview according to DSM-III-R criteria. Diagnoses are based on parent as well as child information. CPAN and CPHOB had significantly more often at least one current mental disorder than children of the healthy control parents. Compared to CPHOB and CCON, children of panic patients had significantly more severe diagnoses and more often multiple diagnoses. Furthermore, a higher rate of internalizing anxiety disorders, particularly separation anxiety disorder, was found in CPAN. In contrast, children of animal phobics showed a higher rate of externalizing anxiety disorders. Our results suggest a specific transmission of such disorders that share common features of parental symptomatology.

Adolescent↗
PubMed1996

[Panic disorder and its psychological treatment].

Over the past decade, panic disorder has become a major research focus in psychopathology and treatment. Initial interest in the causes of the disorder was triggered by biological theories and investigators. More recently, however, research on newly developed psychological approaches has advanced our understanding of panic disorder and has led to the development of specific treatment programs. This review describes symptomatology and course, the psychophysiological model of panic and a psychological treatment that directly targets panic attacks and the fears and behaviors associated with them.

Fear↗
PubMed1995

[When can the family physician do?].

Even when a specific psychotherapy is undertaken, the family physician can be of use for the patient by using appropriate medicine. Hints for the communication, consultation, self-help, and the definite information exchange are given for different forms of anxiety diseases. The adequate diagnosis' elucidation of an anxiety disease is of great importance. The correct sequence of the arguments is helpful in reducing the resistance and for the acceptance of explanations. The problem of a patient's referral to a specialist is discussed.

Anxiety Disorders↗
PubMed1994

Memory bias in panic disorder.

We investigated selective memory effects in patients with panic disorder. Thirty patients with panic disorder and 20 normal controls learned panic-related, strongly pleasant, and strongly unpleasant words. During the incidental learning task, Ss imagined scenes combining the referent of a presented word with themselves. After a distractor task, Ss took a free-recall test. Panic Ss showed enhanced memory for panic-related words but not for positive or negative words.

Adult↗
PubMed1994

[Recommendations for the use of measuring instruments in clinical anxiety research].

The Arbeitskreis Angstforschung (AKA) brings together investigators active in the field of anxiety research and representatives of anxiety disorder outpatient clinics in German speaking countries. During its regular meetings, the decision was made to develop recommendations for the assessment of anxiety disorder patients in clinical studies. A task force of experts in pharmacological and psychotherapeutic treatments established a consensus of opinion to improve standardisation and comparability of studies originating from different centres. The AKA specifically recommends the following set of variables to be collected in all studies: (1) Demographic data: age, gender, marital status, education, employment, and living situation. (2) DIAGNOSIS: diagnoses should be obtained by clinically experienced personnel with special training in the particular assessment instruments. Structured interviews, according to the current versions of the DSM or ICD classifications are recommended. Published reliability and validity data should be available for the interviews. Examples of specific instruments meeting these criteria are given. (3) Symptoms and course: Data on the course of the disorder should cover onset, type of course, timing of episodes, currently active or in remission, as well as a complete treatment history. In addition, patient self-ratings and observer ratings should be obtained in order to allow comparisons across studies, assess the severity and measure treatment outcome. (4) Disability and restrictions in quality of life: these variables should be assessed by rating scales covering work, social and leisure activities, and family relationships. The AKA expects that these recommendations will be helpful to clinical anxiety researchers. Acceptance of common standards should improve the quality and comparability of pharmacological and psychotherapeutic studies in the complex field of anxiety disorders.

Anti-Anxiety Agents↗