Biomedical subjects
Publications and source records attributed to J Mani.
This study evaluates the comparative efficacy of MRI and CT in evaluating facial tumors. MRI, with its excellent contrast on T2 weighted and post-gadolinium sequences, is superior to CT for delineating tumor extension, the information essential for appropriate surgical intervention. Both modalities can sometimes be helpful for tumor characterisation.
A case of postnephrectomy arteriovenous fistula of the right renal pedicle is reported here. The diagnosis was confirmed by angiography, and successful treatment was achieved using detachable balloon.
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The authors report three new cases of anterior ethmoidal dural fistulae: a pure pial and two dural and pial fistulae which presented in the form of rupture. The emphasise the computed tomographic features, revealing a unilateral frontopolar haematoma and the need for angiographic assessment including study of the internal and external carotid arteries. Carotid angiography of the fistula defines the therapeutic modalities which are generally surgical.
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Forty-six patients with defective erection of venous origin were treated by embolization of deep dorsal vein at the Santorini plexus level. Embolization was by insertion of disposable balloons after surgical approach to deep dorsal vein of penis. Follow up showed that 57% of patients had recovered satisfactory, normal sexual activity and 15% a fairly satisfactory sexual activity.
A case report concerning a left primary maxillary meningioma is presented. Clinical, conventional radiographic and CT signs are presented. The diagnosis was made after histologic examination of the specimen. The pathogenesis is discussed.
Twenty-one patients with hepatic metastases were treated by chemoembolization over a 2-year period, the technique consisting of selective injection of a mixture of Spongel powder and Adriamycin plus 5-FU into the hepatic artery. Indications and results are discussed as a function of clinical, biologic and radiologic criteria.
The authors report 25 cases of pre-operative embolisation of tumours of bone or muscle. The aim of this technique is to improve surgical safety by diminishing hemorrhage at operation and to preserve vessels in the region of the tumour especially if secondary intra-arterial chemotherapy is required.
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On computerized tomography the intracranial meningiomas are surrounded by a more or less extensive peritumoral oedema. Twenty patients presenting with a supratentorial meningioma have been studied by angiography and computerized tomography. A constant correlation between the presence of oedema and the type of vascular supply of the tumor has been demonstrated. When there is no oedema, the whole vascular supply of the tumor is provided by the meningeal branches of the external or the internal carotid arteries. When there is a peritumoral oedema, the vascular supply of the portion of the tumor adjacent to the oedema is provided by leptomeningeal branches of the internal carotid. No constant correlation has been demonstrated by the authors between the presence of oedema and the other factors previously described in the literature.
A simple and inexpensive method for the estimation of stannous ion, Sn (II), in radiopharmaceutical kits is described. The method used is a potentiometric titration of Sn (II) in 1 N HCI medium, using potassium iodate as the oxidizing agent in an atmosphere of nitrogen. The apparatus includes pH meter, a platinum electrode, and a simple titration cell. Several commonly used radiopharmaceutical kits were analyzed for their Sn (II) content using this method. These studies indicate that the procedure can be used, as a routine quantitative test for the Sn (II) content of various 99mTc-labeled radiopharmaceuticals.
Case reports of seven patients in whom unusual abnormalities caused widening of the cervical intervertebral foramen are presented. Plain roentgenographic and tomographic changes may be quite distinctive, especially in a patient with an absent pedicle or a tortuous vertebral artery. However, angiography has proved to be a useful adjunct to determine the etiology in many of these lesions.
Clinical findings are often insufficient to diagnose basal arachnoiditis and conventional neuroradiological techniques often fail to demonstrate the inflammatory process. Computed tomographic (CT) scans, however, usually can demonstrate the circle of Willis, and the basilar, sylvian quadrigeminal, and vermian cisterns. Cisternal anatomy can also be delineated on the CT scans by metrizamide cisternography. CT scanning may prove to be the most accurate and sensitive radiographic test for basal arachnoiditis. Findings in three patients are reported.
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In carefully selected cases, superficial temporal artery bypass appears to be a promising and useful method for bringing about an improved collateral supply in problems of occlusive cerebral vascular disease. Such a procedure appears to improve the quality of life.
Rabies caused by fox bite is uncommon, most cases being caused by bite of rabid dogs (95%). We report a 45-year-old lady with rabies encephalomyelitis caused by bite of a rabid wild fox (Vulpes vulpes), a species prevalent in the Deccan plateaus of Central India. Though foxes are known to be susceptible to rabies, literature on the pathological changes caused by fox bite rabies in humans is scarce. Unlike the mild histological alterations described in canine rabies, a florid encephalitic process evolved in fox bite rabies, in our case, with intense microglial reaction, neuronophagia and perivascular inflammatory infiltrates despite clinical manifestation as a paralytic rabies. Immunostaining using polyclonal antibodies to the rabies viral nucleocapsid antigen and to the whole virion demonstrated high viral load within neurons with extensive spread along dendritic arborization and axonal tracts. Genomic sequence analysis demonstrated close homology with canine virus strain with only minor variations.