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Biomedical subjects

J Mancebo

Publications and source records attributed to J Mancebo.

68 records · Page 4Linked to original sources
PubMed1986

Effect of intrinsic positive end-expiratory pressure on respiratory compliance.

We evaluated the influence of intrinsic positive end-expiratory pressure (PEEPi) on the measurement of static respiratory compliance in 15 adult patients with acute respiratory failure under mechanical ventilation. Modifying the inspiratory/expiratory ratio from 1:2 to 2:1, and the respiratory frequency from 15 to 20 and 25 breath/min significantly changed compliance values. Because PEEPi can increase the work of breathing, we suggest adjusting ventilatory variables to minimize PEEPi.

Adult↗
PubMed1986

Post-neurosurgical and spontaneous gram-negative bacillary meningitis in adults.

In order to evaluate the clinical aspects of gram-negative bacillary meningitis (GNBM) we reviewed the charts of 20 adult patients with the discharge diagnosis of meningitis caused by gram-negative bacilli (bacteriologically proved) seen between 1973 and 1984. Nine patients had post-neurosurgical (post-NS) GNBM and 11 patients spontaneous (S) GNBM; the mean age of the former was 42 +/- 16 years and of the latter 56 +/- 14 years (p less than 0.05). The overall mortality rate was 50% (33% in the post-NS group and 64% in the S group). The glucose levels in CSF were significantly lower in the patients who died. Patients treated with combined aminoglycoside therapy presented a lower mortality rate than those treated with intravenous aminoglycoside only (25% versus 70%). We suggest that if aminoglycoside therapy is employed, these antibiotics must be administered both intravenously and directly into CNS.

Adult↗
PubMed1985

Pulmonary compliance measurement in acute respiratory failure.

Many automatic devices to measure effective compliance can now be incorporated in mechanical ventilators. We compared measurements from these devices against those obtained from a pressure-volume curve made with a super-syringe. The methods produced closely correlating results (r = 0.854; p less than .001) in 20 adult patients with acute respiratory failure. Both techniques provide useful information about the elastic properties of the lung and can be used to adjust mechanical ventilation.

Adult↗
PubMed1980

Diffuse intratubular undifferentiated germ cell tumor in both testes of a male subject with a uterus and ipsilateral testicular dysgenesis.

A case of müllerian pseudohermaphroditism in a male subject with a uterus is described. The patient showed normal secondary sex characteristics as well as normal external genitalia, except for right cryptorchidism and a painful tumoral mass in the left testis. Examination of surgical specimens revealed a uterus attached to the left ductus deferens. Areas of seminoma and embryonal carcinoma were present in the left testis. In addition, there was a thin insufficiently collagenized albuginea that contained a cellular connective tissue resembling the ovarian stroma, as well as hypoplastic and atrophic seminiferous tubules. In the testicular parenchyma most of the seminiferous tubules located far away from the tumor possessed the atypical malignant germ cells characteristic of intratubular undifferentiated germ cell tumors. No spermatogenesis was seen. The right abdominal testis was atrophic and showed a normal albuginea. However, there was an undifferentiated germ cell tumor similar to that observed in the left testis. We describe the first case of a tumor in a scrotal testis of a male subject with a uterus. The occurrence of this tumor is discussed with regard to tubular dysgenesis present in both testes and supported by the intrinsically abnormal germ cells as well as by the immature Sertoli cells found in both testes.

Adult↗