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Biomedical subjects

J Maldonado

Publications and source records attributed to J Maldonado.

At least 91 records · Page 5Linked to original sources
PubMed1989

Post-remission therapy in acute myeloblastic leukemia. A randomized trial comparing early consolidation plus maintenance versus maintenance therapy alone.

During a 5-year period 203 previously untreated patients with acute myeloblastic leukemia entered an intensive induction chemotherapy regimen with daunorubicin, cytosine arabinoside, 6-thioguanine, vincristine and prednisone (DATOP). The complete remission rate was 64%. Patients in complete remission were randomly assigned to 3 courses of early consolidation with DATOP at lower dosage followed by maintenance chemotherapy, or to the same maintenance regimen in the absence of any consolidation courses. No significant differences were found between these options concerning disease-free survival (median 7.0 vs. 9.8 months; p greater than 0.10) or survival (median 15.8 vs. 19.4 months; p greater than 0.10). This study, in addition to the few previously reported randomized trials, suggests that early low-dose consolidation adds no benefit to maintenance chemotherapy in acute myeloblastic leukemia once complete remission has been achieved.

Adolescent↗
PubMed1989

[Lipomeningocele: review of 44 cases].

On a review of 500 spina bifidas, the authors presents 44 lypomeningoceles (8.8%). During de first two years of age a clinical follow-up with a T.A.C. and myelography is performed. Depending on the symptoms the surgical intervention is performed after two years of age. The authors described the surgical technique. Urological, gastroenterological and orthopedics sequelae are presented and reviewed.

Female↗
PubMed1989

[Treatment of esophageal stenosis in children].

Esophageal stenoses, both congenital and acquired, represent a serious problem in childhood due to the deleterious effects, of these anomalies in the patients nutritional state and lifestyle. Choosing the best way to the solution of such problems is of primary importance, paying special attention to the techniques that may not compromise irreversibly the continuity of the alimentary tract. The authors experience on the treatment of 77 esophageal stenoses, 8 of which were congenital and 69 acquire, is reported. Of this group, 24 are sequelae of esophageal atresias, 33 are of caustic origin and 12 of peptic nature. In 3 congenital stenoses with a cartilaginous matrix, surgical repair was undertaken. In the remaining cases forward and retrograde dilatation guided by a thread, through the gastrostomy orifice were performed, in accordance to the length and severity of the stenoses. Duration of the treatment varied broadly, ranging from 3-5 anterograde sessions, in the cases of esophageal atresia sequelae, to several years with an average monthly periodicity of one session in cases of total pharyngoesophageal caustic burn. As for complications, there were three cases of mediastinitis and two of subcutaneous infiltrations at the cervical level that were solved with antibiotics. The authors believe, on the basis of their experience, the absence of mortality and the scarce morbidity that, in the pediatric patients the treatment of choice of esophageal stenoses consists of dilatations on their different modalities. A yearly follow-up must be strictly maintained until the patients have completed their growth. We reject esophageal coloplasties in the pediatric age because of their complications rate.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMed1989

[Bolande's tumor: significance of its early diagnosis and treatment].

Four patients diagnosed of having a tumor of Bolande and treated at our institution in the past ten years are presented. In two of them, early diagnosis was aided by prenatal echographic techniques; the other two diagnoses were suspected ar three and ten days of age because of an abdominal mass. The four of them underwent a complete study which included: a plain abdominal film, an ultrasound scan and an intravenous urogram; the last three patients were also surveyed by a CT scan of the abdomen. Surgery was undertaken early on all the patients, the time of operation being in every instance within the first month of life. A laparotomy was performed and, once the contralateral kidney had been carefully examined, a nephroureterectomy was implemented, having been able to preserve in all the cases the suprarenal gland in view of the benign nature of the tumor. A histologic study confirmed the diagnosis and revealed the complete delimitation of the tumor by the renal capsule. The authors underscore the importance of this tumor's suspicion in the face of any solid renal mass detected by prenatal echography or in the neonatal period, since early diagnosis and treatment are imperative in order to prevent the ensuing complications in the rare and unfortunate cases that show a malignant tumoral trend.

Female↗
PubMed1988

Apparent nitrogen balance and 3-methylhistidine urinary excretion in intravenously fed children with trauma and infection.

This study was designed to compare and evaluate the effects of two isocaloric parenteral nutrition infusions, FreAmine and F080, differing in their amino acid composition, on the apparent nitrogen balance and urinary excretion of 3-methylhistidine in children with trauma (n = 27) or grave infection (n = 24). Trauma patients at the beginning of parenteral nutrition showed a more negative nitrogen balance than infected children, but in all children the apparent nitrogen balance increased to become positive and the 3-methylhistidine urinary excretion dropped. No differences related to the amino acid composition of the parenteral nutrition solutions were found. Apparent nitrogen balance and 3-methylhistidine excretion were correlated in all study groups irrespective of urine sample time. The enriched branched chain amino acid solution used for parenteral nutrition of trauma and infected children did not show a better effect than the non-enriched one in terms of muscle catabolism and nitrogen balance. The use of adequate nutritional support including both amino acids and energy source is of major importance in children recovering from trauma and infection.

Amino Acids↗
PubMed1988

Changes in the fatty acid profiles of plasma lipid fractions induced by dietary nucleotides in infants born at term.

This study was designed to determine the polyunsaturated fatty acid (PUFA) composition of plasma lipid fractions in newborn infants fed human milk (HM), milk formula (MF) or nucleotide-supplemented milk formula (NMF) during the first month of life. Linoleic acid was increased in infants fed formulas in all plasma lipid fractions with respect to those fed HM. Plasma phospholipids in MF-fed infants had lower percentages of PUFA of both omega 6 and omega 3 series, namely arachidonic and docosahexaenoic acids, than those fed HM or NMF; the unsaturation index was decreased in infants fed MF as compared to those fed HM or NMF. Arachidonic acid showed a similar behaviour in plasma cholesteryl esters as in phospholipids. No changes for long chain PUFA among the groups studied were observed for plasma triglycerides and free fatty acids. These results support previous findings that dietary nucleotides are involved in the regulation of desaturation and elongation of linoleic and linolenic acid to their longer superior homologous fatty acids. We suggest that dietary nucleotides may reverse the partial inhibition of delta 5-desaturase caused by an excess of linoleic acid in the diet during early postnatal life.

Delivery, Obstetric↗
PubMed1988

A novel CaCl2 continuous infusion screening method for antiarrhythmic and/or calcium antagonist drugs in rat.

The authors describe a new method to screen antiarrhythmics drugs by continuous infusion of calcium chloride in albino rat. Results are compared with those of a single injection method. Three reference compounds were tested: verapamil, nifedipine and trimetazidine. Verapamil and trimetazidine were shown to be equally active by the two methods. A fourth compound, synthetized in the laboratory, was active in the various arrhythmia models and, in particular, in the novel model described.

Anesthesia↗
PubMed1985

The significance of the reflex bronchoconstriction provoked by gastroesophageal reflux in bronchial asthma.

To demonstrate the existence and assess the magnitude of reflex bronchoconstriction in asthmatics, triggered by gastroesophageal reflux, pulmonary function studies (forced expiratory spirogram, flow-volume loops and airway resistance) were performed during a Bernstein test in 21 adult patients with intrinsic asthma and in 15 controls. Six asthmatics and 7 controls had symptomatic reflux test and a positive standard acid reflux test. Bernstein test was positive in all symptomatic individuals and in 2 asthmatics with a negative standard acid reflux test. Changes in pulmonary function occur only in asthmatics with symptomatic reflux. Decreases were: FEV1 8.4 +/- 3.4; FEF25-75% 45 +/- 7.3; Vmax 15 +/- 8.4; and Sgaw 16 +/- 3.7. Although changes were statistically significant (p less than 0.05), the magnitude of decrease is rather small and unlikely to be felt by an asthmatic or produce wheezy dyspnea. Therefore, even though the presence of acid in the lower esophagus may produce reflex bronchoconstriction in some asthmatics with symptomatic reflux, this appears to be of little significance.

Adult↗