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Biomedical subjects

J Maier

Publications and source records attributed to J Maier.

71 records · Page 4Linked to original sources
PubMed1982

Rapid separation of immunoglobulin M by immunoaffinity chromatography for detection of specific antibodies to rubella and Treponema pallidum.

A rapid and easy method for isolating IgM from serum specimens in order to detect specific antibodies against Treponema pallidum and rubella virus by routine serologic procedures is described. Serum IgM was isolated by immunoaffinity chromatography using anti-human IgM antibodies covalently bound to controlled-pore glass beads in a microcolumn. The final concentration of the IgM in the samples tested amounted to at least 16% (average 32%) of the original concentration (corresponding to a serum dilution of 1 : less than 8). IgG contamination did not exceed 0.38% of the original serum concentration. The capacity of the column was stable for at least 50 absorption/elution cycles. The new technique enables rapid and reliable detection of specific IgM by the rubella hemagglutination inhibition and Treponema pallidum hemagglutination tests.

Animals↗
PubMed1979

[Diagnosis and therapy of pancreatic carcinoma (author's transl)].

Report of 143 cases of pancreatic carcinoma and the operations carried out. In 14 cases (operability rate 10%) a pancreaticoduodenectomy was performed. The operative lethality rate came to 14,3%. The longest survival time was 7 1/4 years, the shortest 11 months. Early diagnosis, early laparotomy and operation as radical as possible are emphasized.

Adult↗
PubMedDate not supplied

Mesoscopic fast ion conduction in nanometre-scale planar heterostructures.

Ion conduction is of prime importance for solid-state reactions in ionic systems, and for devices such as high-temperature batteries and fuel cells, chemical filters and sensors. Ionic conductivity in solid electrolytes can be improved by dissolving appropriate impurities into the structure or by introducing interfaces that cause the redistribution of ions in the space-charge regions. Heterojunctions in two-phase systems should be particularly efficient at improving ionic conduction, and a qualitatively different conductivity behaviour is expected when interface spacing is comparable to or smaller than the width of the space-charge regions in comparatively large crystals. Here we report the preparation, by molecular-beam epitaxy, of defined heterolayered films composed of CaF2 and BaF2 that exhibit ionic conductivity (parallel to the interfaces) increasing proportionally with interface density--for interfacial spacing greater than 50 nanometres. The results are in excellent agreement with semi-infinite space-charge calculations, assuming a redistribution of fluoride ions at the interfaces. If the spacing is reduced further, the boundary zones overlap and the predicted mesoscopic size effect is observed. At this point, the single layers lose their individuality and an artificial ionically conducting material with anomalous transport properties is generated. Our results should lead to fundamental insight into ionic contact processes and to tailored ionic conductors of potential relevance for medium-temperature applications.

Journal Article↗