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Biomedical subjects

J Madsen

Publications and source records attributed to J Madsen.

At least 145 records · Page 8Linked to original sources
PubMed1980

Skin temperature and subcutaneous adipose blood flow in man.

The abdominal subcutaneous adipose tissue blood flow (ATBF) was measured bilaterally by the 133Xe washout method. At one side of the skin (epicutaneous) temperature was varied with a temperature blanket, the other side served as control. There was a significant (P less than 0.001) positive correlation between skin temperature and ATBF. In the range from 25 to 37 degrees CATBF increased 9% of the control flow on average per centigrade increase in skin temperature. ATBF at the control side was uninfluenced by the contralateral variations in skin temperature. Although no better correlation could be demonstrated between ATBF and subcutaneous temperature than between ATBF and skin temperature, arguments are presented in favour of the hypothesis that ATBF is influenced by the subcutaneous temperature rather than via reflexes from the skin. Infiltration of the 133Xe depots with 20 microgram histamine increased ATBF 6 fold on average.

Adipose Tissue↗
PubMed1979

Prevalence of epilepsy in children of Melipilla, Chile.

The prevalence of epilepsy among children born in 1966 and reaching the age of 9 years during 1975 was investigated in Melipilla, Chile, using questions similar to those used by Rose et al. (1973). Of 2,104 potential respondents, 2,085 were interviewed. A sample of 593 children received neurological examination and 455 received an electroencephalogram. The prevalence rates for epilepsy were higher than those reported in two American studies using the same methodology. The possibility of socioeconomic factors to account for these differences was considered. Prevalence rates for simple febrile convulsions and minimal brain dysfunction were similarly calculated.

Attention Deficit Disorder with Hyperactivity↗
PubMed1978

Human adipose tissue blood flow during prolonged exercise II.

Subcutaneous and perirenal adipose tissue blood flows (ATBF) were measured by the 133Xe washout method before, during and after 4h exercise on a bicycle ergometer. The load corresponded to about 50% of VO2 max (i.e. about 1.7l/min). Subcutaneous and perirenal ATBF increased at an average to 3--400 and 700% of their initial control values respectively. In six of nine measuring sites ATBF remained increased in the hour following work. During work plasma glycerol concentrations increased 8 fold. The core temperature increased 0.9 degree C, skin temperature did not change significantly. During passive elevation of body temperature (core temperature +1.5 degree C; skin temperature +3 degree C) neither subcutaneous ATBF nor plasma glycerol concentrations changed significantly. It is concluded that the increase in subcutaneous ATBF during exercise is not a reaction to increased body temperature.

Adipose Tissue↗
PubMed1978

Occlusive arterial disease of the child and young adult. Clinical electroencephalographical analysis of 26 cases.

26 patients suffering from acute arterial disease, predominant in childhood and young adults, have been studied. Convulsive symptom and electroencephalographic (EEG) findings are especially analyzed. The series are grouped following the Hilal classification, based on angiographical aspects. The incidence and etiological facts as well as the clinical and the angiographical findings, are summarized. The EEG analysis shows the high incidence of localized or lateralized abnormalities (23 out of 26), closely related with the clinical signs. However, there is no close relationship between these findings and the conscious state of the stage of the disease. An attempt is made to correlate the added diffuse and/or paroxysmal activities with the brain damage suspected by the angiographical signs. Seizures are present in 10 cases, 9 of them as initial symptoms predominantly of the focal type. There seems to be no relationship between the incidence and type of fits and the angiographical findings. Follow-up study shows that seizures do not modify the immediate course of the disease nor the persistence of this sequela in 9 of the controlled patients. The histopathological findings of cerebral vessel involvement are reported.

Adolescent↗
PubMed1976

Adipose tissue blood flow during prolonged, heavy exercise.

Subcutaneous adipose tissue blood flow (ATBF) was examined in 8 subjects during 6 h exercise on a bicycle ergometer. The initial work load was 118 W corresponding to about 50% of maximal work capacity. The oxygen uptake increased from 0.261 - min-1 at rest to about 1.61-min-1 during work. In 7 subjects ATBF increased, in 1 it remained constant. After 3 h exercise ATBF at an average reached values 3--4 times the control value. This increase was maintained for the remaining work periods. The increase was significant at the 5% level. Plasma free fatty acids increased 7-, plasma glycerol 10-fold during work.

Adipose Tissue↗
PubMed1976

Influence of hypoxia and hyperoxia on subcutaneous adipose tissue blood flow in man.

Subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xe washout method in normal men breathing oxygen at partial pressures from 0.1 to 2 atmospheres. Breathing oxygen at partial pressures of 0.1 and 1 atm. increased and reduced ATBF by 56% and 26%, respectively as compared to air breathing. These effects were highly significant. Breathing of oxygen at 2 atm. partial pressure had no consistent effect on ATBF, although considerable changes--positive or negative--could been seen in some experiments. Oxygen-breathing at 1 atm. partial pressure is associated with a slight hyperventilation and fall in PACO2. This was shown to be without importance for the effect of oxygen on adipose tissue blood flow.

Adipose Tissue↗
PubMed1975

Compensation for geometric changes during monitoring of 133Xe washout from subcutaneous adipose tissue.

A method is described for automatic compensation of changes in geometry during monitoring of 133Xe-washout curves from subcutaneous depots. A 99mTc source is placed on the skin over the 133Xe depot, and both isotopes are counted simultaneously. Variations in the 99mTc activity (corrected for radioactive decay) reflects changes in counting geometry and efficiency and are used for correction of the 133Xe elimination curve. The method permits accurate elimination curves to be obtained from subjects exercising on a bicycle ergometer or running a treadmill.

Adipose Tissue↗
PubMed1975

Continuous estimation of adipose tissue blood flow in rats by 133Xe elimination.

A method is described which permits continuous estimation of adipose tissue blood flow (ATBF) in anesthetized female rats. The method is basesd on continuous monitoring of the elimination of 133Xe after labeling of the animal by intraperitoneal injection. From 2 to 6 h after the beginning of the elimination period close to 100% of the measured activity is shown to be located in adipose tissue, mainly in the parametrial fat. About 18% of the elimination is by way of intertissue diffusion, 82% of the perfusing blood. Changes in ATBF can readily be detected. The coefficient of variation for ATBF determinations is 9-11%. Changes in ATBF can be determined with great accuracy. Average ATBF per g tissue for fed and 48-h fasted rats were 0.105 and 0.122 ml-g-1-min-1, respectively. Total ATBF was lower in fasted than in fed rats (1.05 vs. 1.43 ml-min-1 for parametrial plus retroperitoneal fat). Intravenous administration of glucose (250 mg/h) decreased ATBF significantly in fed but not in fasted rats.

Adipose Tissue↗