[Cochlear implantation with preservation of residual deep frequency hearing].
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Cochlear Implantation↗
Biomedical subjects
J Müller
Publications and source records attributed to J Müller.
The structure of microtubule motor proteins.
Microtubules are the intracellular tracks for two classes of motor proteins: kinesins and dyneins. During the past few years, the motor domain structures of several kinesins from different organisms have been determined by X-ray crystallography. Compared with kinesins, dyneins are much larger proteins and attempts to crystallize them have failed so far. Structural information about these proteins comes mostly from electron microscopy. In this chapter, we mainly focus on the crystal structures of kinesin motor domains.
Animals↗
Wave function engineering in elongated semiconductor nanocrystals with heterogeneous carrier confinement.
We explore two routes to wave function engineering in elongated colloidal CdSe/CdS quantum dots, providing deep insight into the intrinsic physics of these low-dimensional heterostructures. Varying the aspect ratio of the nanoparticle allows control over the electron-hole overlap (radiative rate), and external electric fields manipulate the interaction between the delocalized electron and the localized hole. In agreement with theory, this leads to an exceptional size dependent quantum confined Stark effect with field induced intensity modulations, opening applications as electrically switchable single photon sources.
Journal Article↗
[Investigation about the clinical use of brushite- and hydroxylapatite-cement in sheep].
For future clinical use as synthetic bone replacement, an injectable brushite-(chronOS-Inject) and hydroxylapatite-(Biobon) cement were compared in a drill hole model in 10 sheep over time at 2, 4, 6, 8, 16 and 24 weeks. Results were compared regarding their practical use, biocompatibiliy, resorption mechanism and subsequent new bone formation. The cements were filled into drill holes (psi 8 x 13mm) of the proximal and distal humerus, and femur and the samples evaluated macroscopically, radiologically and microscopically including histomorphometrical quantification of percentages of new bone, fibrous tissue and remnants of cements. The cement area decreased continuously from 2 to 24 weeks with chronOS-Inject, as well as the area of granules. Inversely, the subsequent new bone formation increased from 2-24 weeks accordingly. With Biobon the cement area decreased slower between 2 and 24 weeks, and the new bone formation was less. Both cements were well integrated into the bone in long bones. chronOS-Inject demonstrated good biocompatibility and was almost completely replaced through bone within 24 weeks. Biobon was resorbed considerably slower and initially a slight inflammatory reaction including bone resorption was observed within the adjacent host bone.
Absorbable Implants↗
Sonographic imaging of the distal biceps tendon -- an experimental and clinical study.
AIM: With this study we aimed to determine the reliability of ultrasound imaging in depicting the normal anatomy of the distal biceps tendon in human cadaver specimens and to provide an accurate visualisation of ruptures of the distal biceps tendon in healthy volunteers. METHOD: The distal biceps tendons of six whole-arm human cadaver specimens were investigated. The tendons were subsequently marked with a biopsy needle and re-examined. In addition, ultrasound imaging of the distal biceps tendon was performed in 25 healthy volunteers (50 sonograms). All examinations were carried out using linear ultrasonic transducers of various frequencies (5 - 13.5 MHz). The sonographic images were submitted to two experienced examiners for analysis. RESULTS: Positive identification of the tendon was achieved in all cases. The best results were achieved using 7.5 MHz transducers. Our study also suggests that the medial longitudinal scan and the articular transversal scan are a definite prerequisite for a correct diagnosis in the region of the distal biceps tendon. The dynamic examination is very useful to visualise the tendon with sufficient accuracy. CONCLUSION: Based on this study, ultrasound imaging is recommended as the method of choice for visualisation of the distal biceps tendon if performed with the necessary accuracy.
Adult↗
[Hearing disorder. Mechanical management of hearing loss: cochlear implants and brain stem implants--current developments in the last 10 years].
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Adolescent↗
International consensus on bilateral cochlear implants and bimodal stimulation.
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Adult↗
Insensitivity of cardiovascular function to low power cm-/mm-microwaves.
A previous study failed to disclose an effect of short (15 min) exposure to low level energy microwaves (3 microW/cm2) emitted by a commercially available automobile radar system (77 GHz) for adaptive cruise control (ACC) on cardiovascular function. The present study explored whether a 15 min exposure to higher level energy microwaves of frequencies varying from 5.8 to 110 GHz influences cardiovascular function. To this end heart rate, skin temperature (thermocouple), skin conductance (Ag/AgCl electrodes), systolic and diastolic blood pressure (automatic cuff) were recorded in 50 test persons before, during and after a 15 min exposure to a sequential pattern of microwaves varying from 5.8 to 110 GHz (59.7 microW/cm2). After an equilibration period of 30 min the first group of test persons and after additional 30 min the second group of test persons were exposed. The study has been performed in a strict double blind design. While significant effects on the measured parameters were observed depending on time ("calming" effect), no significant difference was observed between exposure and sham exposure to microwaves. In view of the small scatter of the data the present study rules out physiologically relevant effects of moderate energy (59.7 microW/cm2) microwaves varying from 5.8 to 110 GHz on cardiovascular function.
Adolescent↗
Anisotropic adaptive finite element method for modelling blood flow.
In this study, we present an adaptive anisotropic finite element method (FEM) and demonstrate how computational efficiency can be increased when applying the method to the simulation of blood flow in the cardiovascular system. We use the SUPG formulation for the transient 3D incompressible Navier-Stokes equations which are discretised by linear finite elements for both the pressure and the velocity field. Given the pulsatile nature of the flow in blood vessels we have pursued adaptivity based on the average flow over a cardiac cycle. Error indicators are derived to define an anisotropic mesh metric field. Mesh modification algorithms are used to anisotropically adapt the mesh according to the desired size field. We demonstrate the efficiency of the method by first applying it to pulsatile flow in a straight cylindrical vessel and then to a porcine aorta with a stenosis bypassed by a graft. We demonstrate that the use of an anisotropic adaptive FEM can result in an order of magnitude reduction in computing time with no loss of accuracy compared to analyses obtained with uniform meshes.
Adaptation, Physiological↗
Monitoring surface charge movement in single elongated semiconductor nanocrystals.
We demonstrate a universal correlation between the spectral linewidth and position of the excitonic transition in the spectral jitter observed from single elongated colloidal quantum dots. Breaking the symmetry of electron and hole confinement as well as of the spatial directions for surface charge diffusion enables us to microscopically track meandering surface charges, providing a novel probe of the particle's nanoenvironment. Spectral diffusion exhibits only a weak temperature dependence, which allows us to uncover the single particle homogeneous linewidth of 50 meV at room temperature.
Journal Article↗
Raman microscopic investigations of BaTiO(3) precursors with core-shell structure.
Due to their outstanding dielectric and ferroelectric properties, barium titanate (BaTiO(3))-based ceramics have found many applications in electronic devices. To optimise the final quality of such ceramics, a detailed knowledge of the complex processes involved in the formation of BaTiO(3) is required. The phase formation process in ordered structures of the BaCO(3)/TiO(2) system was analysed by X-ray diffraction and by Raman spectral imaging (RSI) as a function of the annealing temperature. RSI was used for the first time as a locally resolving method for phase analysis, and proved to be a useful tool in examining the formation process of BaTiO(3) starting from spherical, core-shell structured precursors of the type TiO(2) core/BaCO(3) shell. The Raman spectra of different BaO-TiO(2) phases appearing as intermediate phases during the formation of BaTiO(3) were recorded for separately-prepared pure substances. Using these spectra as fingerprints, and choosing phase filters by setting wave number windows, "phase landscape pictures" of the samples at different temperatures during the genesis of BaTiO(3) could be created with a lateral resolution of up to 200 nm. These pictures confirm shell-like formation of the different barium titanate phases according to the diffusion of barium and oxygen ions from the Ba-rich shell into the TiO(2) core. At an intermediate state of the phase formation process, the phase sequence Ba(2)TiO(4), BaTiO(3), BaTi(2)O(5), BaTi(4)O(9) and BaTi(5)O(11) to TiO(2) was detected from the outer to the inner parts of the core-shell structures.
Barium Compounds↗
Mutational analysis of genes encoding chromatin proteins in the archaeon Methanococcus voltae indicates their involvement in the regulation of gene expression.
Several genes for chromatin proteins are known in Archaea. These include histones and histone-like proteins in Euryarchaeota, and a DNA binding protein, Alba, which was first detected in the crenarchaeote Sulfolobus solfataricus and is thought to be involved in transcriptional regulation. The methanogenic archaeon Methanococcus voltae harbors four genes coding for all these three types of chromatin proteins. Deletion mutants for the two histone genes ( hstAand hstB), the gene encoding the histone-like protein ( hmvA) and the gene for the Alba homologue ( albA) have now been constructed in this organism. Although all single mutants were viable, deletion of hstA resulted in slow growth. Two transcripts were detected for each of the two histone genes. These were expressed in different relative amounts, which were correlated with different growth phases. Cell extracts obtained from the different mutants exhibited altered protein patterns, as revealed by 2D gel electrophoresis, indicating that the chromatin proteins are involved in gene regulation in M. voltae.
Amino Acid Sequence↗
Correlation between invasion of Caco-2 eukaryotic cells and colonization ability in the chick gut in Campylobacter jejuni.
In an in vitro cell culture model using Caco-2 cells the adhesion and invasion properties of 11 Campylobacter (C.) jejuni isolates of different origin were studied. Additionally, we investigated the colonization ability of the strains in a chick model. Virtually, all C. jejuni showed cell adherence in the in vitro assay, but there were large differences in the invasion frequencies among the Campylobacter isolates. The colonization ability in the chick gut also differed markedly and enabled the formation of three groups: non-colonizing, weak or delayed colonization and strong colonization ability. On this occasion, we found a putative correlation between invasion of Caco-2 cells and colonization in the chick gut. Non-colonizers are not invasive or only have small invasion indexes. Strains which colonize weakly or exhibit delayed colonization have a medium invasion index and strong colonizers show markedly higher values of this parameter. The characterization of the flagellin gene of the used C. jejuni strains resulted in eight flaA types. There was no association between flaA type and invasion or colonization ability in the chick gut.
Animals↗
Bilateral cochlear implants: a way to optimize auditory perception abilities in deaf children?
OBJECTIVES: The Würzburg bilateral cochlear implant (CI) program was started with the aim to improve the patients' communicative abilities in complex listening situations. In this study, the auditory skills of children using bilateral cochlear implants were evaluated. STUDY DESIGN AND SETTINGS: Qualitative data based on free observations in the rehabilitation setup were collected in 39 bilaterally implanted children. A speech discrimination in noise test was performed in 18 of these children; lists of bisyllabic words were presented in noise at a signal to noise ratio (SNR) of +15 dB. RESULTS: Qualitative and quantitative data show clearly that bilateral CI improves the children's communicative behaviour, especially in complex listening situations. Children examined with the speech in noise test scored significantly better under the bilateral condition compared to the unilateral condition. Integration of the second implanted side and use of binaural information was observed to be easier and faster in children with a short time lag between both implants. CONCLUSIONS: To be able to obtain optimal benefit from bilateral cochlear implants, an intensive rehabilitation program is necessary. The important aspects of such a program are creating realistic expectations in older children before implantation; performing the first processor fitting of the second side with the first side switched on; and separate intensive training with the new system in order to balance out the hearing competence of the second CI with that of the first.
Adolescent↗
Outdoor use, tonic immobility, heterophil/lymphocyte ratio and feather condition in free-range laying hens of different genotype.
1. Movement (frequency of changes) between inside and outside housing areas, time spent in each area, tonic immobility (TI) and differential blood cell counts were studied in relation to feather condition in laying hens of two genotypes, white (LSL) and brown (LT). 2. From 18 weeks of age, LSL and LT were kept in 4 groups of 50 birds in a poultry house with passages to a roofed scratching room and a grassland area with a stocking density of one bird/10 m2. 3. All birds had transponders to record the movements of each hen between inside and outside areas and the time spent in each area during 24 h. Feather scoring was carried out at 6 ages from 20 to 48 weeks. At 44 weeks of age, TI reactions of 40 hens (20 from each genotype) were quantified and blood smears from 20 hens (10 from each genotype) were analysed for differential leucocyte counts. 4. LSL hens moved more frequently to outdoor areas than LT hens (44.66 vs 28.78 least square/d). However, the proportion of time spent on grassland was greater in LT than in LSL hens, whereas time (%) spent by LT hens in the roofed scratching area was less than for LSI hens. 5. In LT hens TI was shorter while heterophil/lymphocyte ratio and basophilia were greater than in LSL hens. 6. Total body feather score was poorer in LSL than in LT hens. Incidence of footpad inflammation was higher in LSL than LT hens. 7. There was a positive association between TI and footpad inflammation. The percentage of time spent on grassland and feather damage were inversely correlated. 8. More movement between the areas, as in LSL hens, was positively associated with fearfulness, whereas long periods on grassland, as in LT hens, were associated with indicators of increased stress. The negative correlation between feather damage and time spent outside suggests that feather pecking risk decreases in birds attracted to grassland.
Aggression↗
Influence of low power cm-/mm-microwaves on cardiovascular function.
The present study has been designed to investigate physiological effects of short (15 min) exposure to low level energy microwaves (< 10 microW cm(-2)). To this end heart rate, PQ, QS and ST (electrocardiography), respiration (conductive stretch band around the thorax), skin temperature (thermocouple), skin conductance (Ag/AgCl electrodes), systolic and diastolic blood pressure (automatic cuff) were continuously recorded in a group of 50 test persons before, during and after a 15 min exposure to 3 microW cm(-2) high frequency (77 GHz) microwaves. After an equilibration period of 30 min the first group of test persons and after additional 30 min the second group of test persons were exposed. The study has been performed in a strict double blind design. While significant effects on the measured parameters were observed depending on time ('calming' effect), no significant difference was observed between exposure and sham exposure to microwaves. In view of the small scatter of the data the present study rules out physiologically relevant effects of low level energy on the autonomic nervous system and cardiovascular function.
Adolescent↗
First human immunodeficiency virus-1 group O infection in a European blood donor.
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Adult↗