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Biomedical subjects

J M Verlander

Publications and source records attributed to J M Verlander.

6 recordsLinked to original sources

Somatosensory-evoked response of ataxic Angora goats in suspected haloxon-delayed neurotoxicity.

Somatosensory-evoked responses (SER) were recorded in 3 Angora goats with moderate posterior paresis. The cause of posterior paresis was unknown. The goats had recently been given haloxon and had also been grazing in a pasture with carpetweed (Kallstroemia hirsutissima). Haloxon and carpetweed have each been reported to cause posterior paresis in livestock. An electrical stimulus applied subcutaneously in the pelvic limb of the affected goats failed to evoke an SER at the cerebral cortex. Electrical stimulation in the thoracic limb evoked a normal-appearing SER. The absence of SER from pelvic limb stimulation indicated a functional impairment of the somatosensory pathways.

Animals↗

The clinical use of cocaine.

Cocaine is an extremely useful drug for various otolaryngologic procedures, and as an anesthetic it is unrivaled for vasoconstriction and decongestion. Its use should not be restricted any more than any other controlled drug. In the majority of procedures 200 to 300 mg. of cocaine is sufficient to obtain adequate anesthesia, decongestion, and vasoconstriction. In cases in which this amount may be less than adequate, injections of lidocaine with epinephrine can be used to supplement the anesthetic action of cocaine. It is difficult to imagine a case requiring 1000 mg. of cocaine as some physicians have reported in the past. To prevent mistaken injections of cocaine solutions, we recommend that they be colored by the pharmacy. To prevent overdosing we recommend starting with a known amount and not exceeding this total dose. We have chosen 200 to 300 mg. as our total dose for most adult procedures. Some pharmacies prepare 250 mg. of cocaine base in saline for those who prefer a cocaine "slush"; this, too, would be acceptable.

Anesthesia, Local↗

Radio telemetry system for obtaining body temperature during simulated diving to 1000 FSW.

An implantable radio telemetry system for transmitting deep body temperatures from dogs subjected to hyperbaric conditions was designed and tested. The design was adapted from a transmitter described by J. L. Riley, and was successfully tested both in vitro and in vivo to a simulated depth of 1000 FSW. Circuit schematic, printed circuit layout, and component layout are given.

Animals↗

Computer analysis of the electroencephalographic activity of the Caiman olfactory bulb.

Bipolar EEG records of olfactory activity of Caiman sclerops were computer analyzed and the derived power spectral density functions (PSD) were statistically compared by the method of Bendat and Piersol (1971) and Fails and Verlander (1977). These recordings included surface and underwater episodes. The Caiman olfactory EEG may legitimately be divided into four types of activity: a spindle form of high amplitude and long duration (1-3 sec), a spindle of lower amplitude, short duration (less than 1 sec) and significantly lower power generation irregular surface background activity, and an irregular underwater activity. PSD analysis showed a great deal of moment-to-moment variability in both quantity of power generated and the frequency regions containing significant power generation during surface background activity. A statistical comparison of surface background and underwater background activity also showed significant differences.

Animals↗

Statistical comparison of power spectra: a computer program.

A general computer program, of interest to neurobiologists, for comparison of uncorrelated power spectra is presented. The program, ALPHAF, is written in Fortran V language and is easily compiled and executed in any computer with a Fortran software package. The purpose of the program is to read power spectral density (PSD) values into a computer from digital tape and then perform the following functions: (1) compute and report power; (2) compute and report averages of the computed power values over selected frequency bands and (3) compute and report statistical standardised normal distributions for a frequency spectrum of interest. The standardised normal distribution statistic is derived by using equation 7.20, page 250 of Random data: Analysis and measurement procedures (Bendat and Piersol, 1971).

Computers↗