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Biomedical subjects

J M Tanner

Publications and source records attributed to J M Tanner.

At least 73 records · Page 4Linked to original sources
PubMed1976

Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.

New charts for height, weight, height velocity, and weight velocity are presented for clinical (as opposed to population survey) use. They are based on longitudinal-type growth curves, using the same data as in the British 1965 growth standards. In the velocity standards centiles are given for children who are early- and late-maturing as well as for those who mature at the average age (thus extending the use of the previous charts). Limits of normality for the age of occurrence of the adolescent growth spurt are given and also for the successive stages of penis, testes, and pubic hair development in boys, and for stages of breast and pubic hair development in girls.

Adolescent↗
PubMed1976

Dose dependence of growth response to human growth hormone in growth hormone deficiency.

A trial of the relative effect on growth of 20 IU/week and 10 IU/week of human growth hormone has been made in 38 patients with "isolated" growth hormone deficiency over 1 year of treatment, 18 patients over 2 years and 10 over 3 years, and in 17 patients with surgically treated craniopharyngiomata over 1 year. The velocity of height growth in the first year of treatment, compared with a full year of pre-treatment control, was 1.3 times as great in both groups of patients on the larger dose as it was in those on the smaller one. Second-degree equations fitted to the treatment catch-up curve gave estimates of 1.7 cm more height gained on the larger dose by the end of the first year, 2.7 cm by the end of the second, and 3.4 cm by the end of the third. Adjusting treatment increment by covariance for bone age at the beginning of treatment, pre-treatment velocity, and body surface area did not alter these mean differences. Bone age velocity during treatment was the same in both treatment groups (mean 1.09 "years"/year in the first year); thus we anticipate a gain in final adult height of the order of 10 cm from employing the larger dose. The decrease in skin folds occurring on treatment, however, was no different with the larger than with the smaller dose. This reinforces previous observations that the short-term metabolic and longer-term auxologic effects of hGH are not necessarily related.

Adolescent↗
PubMed1975

The 1972 Cuban national child growth study as an example of population health monitoring: design and methods.

A stratified 3-stage random sample of 50 360 children ages 0-19 drawn from the whole population of Cuba was measured in a large-scale growth study during 1972-73. Fifteen anthropometric measurements were taken and puberty stages and menarche status were assessed. Hand-wrist radiographs were done on 10% of the sample. Information regarding the social and education status of the parents was obtained and parental heights were measured. One year later, 30% of the sample were re-measured and 10% re-X-rayed. The overall response rate was 96% at pre-school and primary school age, and a lettle less later. Quality control sessions were held at which the nine measuring teams compared results. No significant differences were found between teams working different parts of the island. Differences between duplicate measurements of stature by individual measurers had standard deviations approximating 0.20 cm. Individual measurers' means differed from the grand means of all measurers by up to +/- 0.2 cm for stature, +/- 0.4 cm for sitting height and +/- 0.5 mm (7% of mean) for triceps skinfold. One or more measurements lay outside the 3rd-97th centile limits in 21% of individuals. Scrutiny of these individuals' records resulted in elimination of measurements in amounts ranging from 0.1% (triceps skinfold) to 1.1% (crown-rump length). Problems of planning and execution of growth surveys designed to set national standards are described, and solutions given or suggested.

Adolescent↗
PubMed1975

Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height.

Multiple regression equations for predicting the adult height of boys and girls from height and bone age at ages 4 and upwards are presented. There is a separate equation for each half year of chronological age; and for pre- and postmenarcheal girls at ages 11 to 14. These are based on longitudinal data from 116 boys and 95 girls of the Harpenden Growth Study and the London group of the International Children's Centre longitudinal study. The bone age used is the revised version of the Tanner-Whitehouse standards, omitting the score for carpal bones (RUS age, TW 2 system). Boys aged 4 to 12 are predicted in 95% of instances to within plus or minus 7 cm of true height, and at ages 13 and 14 to within plus or minus 6 cm. Girls ages 4 to 11 are predicted to within plus or minus 6 cm; premenarcheal girls aged 12 and 13 to within plus or minus 5 and plus or minus 4 cm, respectively; and postmenarcheal girls aged 12 and 13 to within plus or minus 4 and plus or minus 3 cm, respectively. Prediction can be somewhat imporved by allowing for midparent height. One-third of the amount that midparent height differs from mean midparent height is added or subtracted. An alternative system of equations which are based on initial classification by bone age rather than chronological age is given. These have about the same accuracy as the equations based on initial classification by chronological age, but allowance for bone age retardation is less. It is not clear which system is preferable. The equations probably apply to girls complaining of tall stature and boys or girls complaining of shortness and needing reassurance as to normality. In clearly pathological children, such as those with endocrinopathies, they do not apply.

Adolescent↗
PubMed1975

Revised standards for triceps and subscapular skinfolds in British children.

Revised centile standards are given for triceps and subscapular skinfold measurements in boys and girls aged from one month to 19 years. The school age data are based on London measurements made in 1966, and the infant data on Midland Infant Welfare Clinic figures in 1966-67. All centiles are above those given in the earlier standards published in 1962, and particularly so in infancy. It is emphasized that the standards represent what is, not what ought to be.

Adolescent↗
PubMed1975

The natural history of the Silver-Russell syndrome: a longitudinal study of thirty-nine cases.

The growth of 39 children with Silver-Russell syndrome has been followed for 1-13 years. Pregnancy and labor were normal; none of the 61 sibs had the syndrome. Height at referral (mean age 4.6 years) averaged 3.6 SD below the mean and remained at this level during subsequent growth. Bone age averaged 69 percent of normal at referral but caught up by puberty, which occurred at the normal time. Nineteen cases were treated with human growth hormone without lasting effect. There is no clear-cut distinction between the Silver and Russell syndromes; the name should be Silver-Russell. It is likely that some 10 percent of cases have birth weights in the minus 1.5 to minus 2.0 SD range.

Abnormalities, Multiple↗
PubMed1975

A note on the bone age at which patients with true isolated growth hormone deficiency enter puberty.

Nineteen boys with true isolated growth hormone deficiency developed the first stages of puberty at an average bone age of 12.0"years" (Tanner Whitehouse Method 2, RUS score). The average chronological age was 15.0 years. Seven similar girls entered puberty at 10.9"years" in bone age and 13.7 years in chronological age. The means and ranges of bone age at beginning of puberty of these patients are very close to those of normal children.

Adolescent↗
PubMed1974

Diurnal variation in stature and sitting height in 12-14-year-old boys.

1. Measurements of stature and sitting height were made at 0930 and 1400 h on 19 boys aged 12-14 years with the "stretching upward" technique. 11 different boys were similarly measured at 1000 and 1700 h. 2. The average decrease in stature from 0930 to 1400 h was 2.0 mm and from 1000 to 1700 h was 4.6 mm. The corresponding values for sitting height were 2.0 mm and 2.8 mm. 3. No strong evidence for individual differences in diurnal change was found. 4. The standard error of stature measurement, estimated from duplicate measurements taken five minutes apart by the same observer in the afternoon sessions, was +/- 1.8 mm.

Adolescent↗
PubMed1973

Growing up.

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Adolescent↗