Search PubMed⌕ Search

Biomedical subjects

J M Suc

Publications and source records attributed to J M Suc.

At least 127 records · Page 7Linked to original sources
PubMed1981

[Kidney allograft in familial Mediterranean fever a case report and review of the literature (author's transl)].

Chronic renal insufficiency in an Algerian patient with familial mediterranean fever and amyloidosis was treated by kidney transplantation. Diagnosis of the affection was confirmed by the onset of typical acute episodes during haemodialysis, and a bone marrow biopsy established the presence of amyloidosis. The transplant was unsuccessful at an early stage with infective complications. The incidence of similar complications and deaths (11 cases) was particularly high in the 23 previously reported patients in whom transplants had been performed, and no definite relationship was able to be established between the course of the disease and treatment by haemodialysis or transplantation. The functional prognosis of the transplant was apparently not adversely affected by the recurrence of amyloidosis in 3 cases.

Amyloidosis↗
PubMed1980

Specificity and nephrotoxicity of heterologous antibodies directed against renal basement membranes.

Two immune sera have been raised in sheep against rabbit glomerular and tubular basement membranes, respectively (GBM and TBM). Their specificity was investigated by immunoabsorption and radioimmunoassay, and their nephrotoxicity was studied by injecting them into New Zealand rabbits. Both antisera reacted in vitro collagen and noncollagen-related glycopeptides. However, while the anti-GBM antiserum reacted preponderantly with GBM and TBM collagen which probably represent the antigen(s) shared by the two basement membranes, the anti-TBM antiserum was directed preferentially against the noncollagenous component of rabbit TBM. The anti-GBM antiserum induced in rabbits a diffuse extracapillary glomerulonephritis with linear fixation of autologous IgG and C3 along the GBM. The anti-TBM antiserum also induced an extracapillary glomerulonephritis but in addition a focal tubular atrophy was seen and autologous IgG and C3 were fixed along both GBM and TBM and glucosuria frequently occurred. These results suggested that the glomerular lesions induced by the two antisera were due to anticollagen antibodies while the tubulointerstitial lesions were due to antibodies directed against the noncollagenous portion of TBM.

Animals↗
PubMed1980

Mesangial isolated C3 deposition in patients with recurrent or persistent hematuria.

We reviewed 222 renal biopsies performed on patients with nonurologic hematuria alone or hematuria and proteinuria. This review revealed 31 patients who presented minor glomerular abnormalities with granular mesangial C3 deposition without any immunoglobulin or other complement component deposits. These patients presented with gross hematuria in five cases, microscopic hematuria alone in 12 cases, and proteinuria and microscopic hematuria in 14 cases. Light microscopy disclosed a segmentally increased mesangial matrix, sometimes associated with a segmental and focal mesangial hypercellularity. Focal tubulointerstitial and arteriolar lesions occurred in seven cases. In all cases, immunofluorescence showed diffuse granular mesangial deposition of C3. However, the deposits were not observed along the glomerular and tubular basement membranes. We should point out the high frequency of arteriolar C3 deposits (27 of 31). They were either isolated or associated with IgM or other complement components. Using electron microscopy, an increase of mesangial matrix and/or a proliferation of mesangial cells was observed. In two cases, electron-dense deposits were present in the mesangium. Glomerular basement membranes were normal in all but five cases, where they appeared segmentally thickened. After a 3-year follow-up study the clinical features remained unchanged.

Adolescent↗
PubMed1980

Long term effect of captopril in hypertension with chronic renal failure.

We report the use of the orally active converting enzyme inhibitor Captopril in hypertensive patients with mild chronic renal failure. Twenty eight patients were followed for a period of six months. Eleven patients required the addition of furosemide. Mean arterial pressure (MAP) decreased in all but two at six months (MAP: 102 +/- 0.8 vs 133 +/- 2.2mmHg, p less than 0.001). Untoward effects were frequent: the commonest reactions are loss of taste (four patients), skin rashes (11 patients), proteinuria (2 patients), tachycardia (2 cases). These side effects disappeared after reduction of dose (10 cases) or withdrawal (8 cases). Patients on 300mg daily or less were free of any untoward effect. In summary (i) Captopril alone or in combination with furosemide has an antihypertensive effect in patients with chronic renal failure and hypertension; (ii) side effects seem to be dose dependant and a reduced dosage should be used in these patients.

Blood Pressure↗
PubMed1980

[A technique of transposed dog kidney perfusion at steady pressure (author's transl)].

One limitation of the technique of isolated dog kidney perfusion with heparinized blood is the progressive impairment of the organ function which leads to perfuse separately and simultaneously the two kidneys of the same animal with two identical apparatuses, one of the kidneys being used as a control. In order to overcome this difficulty, we describe a technique of perfusion where the kidney is transposed to the femoral or the carotido-jugular vessels. Interposition of a reservoir and a ventricular pump between the vessels and the kidney secures perfusion at a steady pressure. In 10 experiments, haemodynamics and functions of the kidneys remained steady and nearly normal during a 150 min perfusion.

Animals↗
PubMed1979

A correlative study of immunofluorescence, electron, and light microscopy in immunologically mediated renal tubular disease in man.

Renal biopsy specimens obtained from patients with various chronic nephropathies were studied by immunofluorescence (IF), electron and light microscopy. Of 49 biopsies studied by IF, 22 had granular deposits of IgG and/or C3 along the basement membranes of proximal tubules while 14 had linear and 13 both linear and granular deposits. The possible importance of immunologically mediated renal tubular lesions in chronic nephropathies is discussed.

Basement Membrane↗
PubMed1979

[Are surgical renal biopsies useful for clinical prognosis in renal artery stenosis?].

The most significant results show the predominance of arteriolar lesions in the controlateral kidney, The most significant results show the predotients with unilateral renal artery stenosis. and parenchymal lesions of the kidney with stenosis in patients with atherosclerosis. These results do not seem to provide information which would alter the clinical management in any particular case.

Adult↗
PubMed1979

Postpartum hemolytic uremic syndrome: a study of three cases with a review of the literature.

Three cases of postpartum hemolytic uremic syndrome (HUS) are presented. Symptoms of acute renal failure, hypertension and microangiopathic hemolytic anemia with thrombocytopenia occurred 10, 17 and 24 days after delivery. Despite early heparin therapy in all cases, one patient went into terminal renal failure needing chronic hemodialysis, with persistent hypertension which became uncontrollable requiring bilateral nephrectomy 6 months later. The second patient had diuresis one month after starting hemodialysis, but 3 months later developed malignant hypertension. Slight improvement in renal function with persistent hypertension occurred after hemodialysis for 20 months. The third patient showed complete clinical recovery after 2 months. Pathological examination of renal tissue showed the typical lesions of thrombotic microangiopathy (TMA). However, striking differences were observed in the lesion seen in early and late specimens. Early lesions could be differenciated from infancy TMA because the medium-dize arteries were more severely involved. Late lesions were variable, ranging from minor changes in glomeruli and blood vessels, via ischemic and sclerotic lesions in glomeruli with arteriolosclerosis, to the vascular and glomerular lesions seen in malignant nephrosclerosis. There was a good correlation between the renal pathology and the clinical outcome of the patients. HUS with renal TMA as a cuase of postpartum renal failure has been reported in 49 patients with a fatal outcome in 61%. The pathogenesis of the syndrome probably involves a primary endothelial damage. This causes local renal intravascular coagulation in the presence of the usual postpartum hypercoagulable state. This is shown by the presence of fibrin-fibrinogen in glomeruli and vessels, increased plasma fibrin degradation products, thrombocytopenia and lowered levels of coagulation factors. There is little hematological or pathological evidence fo disseminated intravascular coagulation or an immune-complex disease. Hypocomplementemia seen frequently is probably due to local C3 activation via the alternative pathway.

Adult↗
PubMed1978

Study of light-, electron- and immunofluorescence microscopy of urinary sediment in amyloidosis.

Urinary sediment of 11 patients with amyloidosis and 12 without (with proteinuria or in good health) have been sutdied by different morphological techniques. By light microscopy, an amyloid-related substance was occasionally demonstrated both in patients with amyloidosis and in control subjects. Immunofluorescence (IF) showed substance A (amyloid component) to be present in some cases of amyloidosis and in controls. On electron-microscopy, fibrils with characteristic appearance of amyloid substance were found in some cases of amyloidosis (4 out of 11), but were also found in controls. It therefore seems difficult to establish the diagnosis of amyloidosis by microscopic studies of the urinary sediment.

Amyloid↗