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Biomedical subjects

J M Stevens

Publications and source records attributed to J M Stevens.

173 records · Page 10Linked to original sources

A comparison of the performance of three multiple choice question papers in obstetrics and gynaecology over a period of three years administered at five London medical schools.

Four, and later five, of the medical schools in the one multiple choice question (MCQ) paper in Obstertrics and Gynaecology to their students at the end of the Obstetrics and Gynaecology courses. The paper was amended twice after intervals of approximately 12 months. The results showed differences in performance between the five schools on questions and alternatives within questions, which were common to all editions of the paper (the "short" paper). These differences were also shown in the first two editions of the full paper (the "long" paper), but were not apparent in the third. There was a significant improvement in performance from the first to the second paper edition of the long by approximately 11%, but this was reversed from the second to the third edition, where there was a significant decrease in performance by approximately 4%. We cannot here exclude the possibility that this decrease in the third edition has resulted from sample bias. The rank order of the schools may result from differences in methods of teaching. It seems that such relative performance between London medical schools in contributed to by the differences in course legnth and by the occurence of mid-course test. It appears also that student performance in any of the schools has not been uniform over the period of the study, there being a peak during the period when the second edition of the paper was used. Variations in student selection occuring between schools may effect some of these differences. There was also a marked difference in students' performance between Obstetrics and Gynaecology. The short papers appeared easier than the full papers. Whilst this may due to the greater clarity of phrasing for the questions of the short paper, we also believe the subject matter of the short paper may be more relevant. A distinct effect could also be shown, over the period, due to improvements in the wording of the questions. It is possible that students perform better at Obstetrics than at Gynaecology.

Curriculum↗

Inhibition by bromoestrogens of the effects of estradiol on apomorphine-induced climbing behavior.

The chronic administration of estrogens to mice or rats will result in antidopaminergic effects. Apomorphine-induced climbing behavior in mice, the result of direct stimulation of dopamine receptors in the striatal and mesolimbic regions, is a simple animal model for examining these antidopaminergic effects of estrogens. Bromoestrogens, inhibitors of catechol estrogen formation, have been utilized in order to examine the role of estrogen metabolism in dopaminergic antagonism. Mice were pretreated for 3 days with 2-bromoestradiol, 4-bromoestradiol, or 2,4-dibromoestradiol dibenzoates alone or in combination with estradiol benzoate prior to apomorphine administration. The haloestrogens did not alter the climbing-induced responses elicited by apomorphine, whereas estradiol benzoate clearly attentuated the actions of apomorphine. Furthermore, the bromoestradiol dibenzoates were effective in reversing the effects of estradiol benzoate when the two steroids (estradiol benzoate and a bromoestrogen dibenzoate) were administered simultaneously during pretreatment. Thus, the bromoestrogens are able to inhibit the antidopaminergic effects of estradiol exhibited in the apomorphine-induced mouse climbing model.

Animals↗

Gynaecology from ancient Egypt: The papyrus Kahun: A translation of the oldest treatise on gynaecology that has survived from the ancient world.

This article presents a new translation of the papyrus Kahun. Interest in the papyrus lies in its being indisputably the most ancient document on gynaecology known. The text consists of a continuum of individual "cases" which lend themselves to subdivsion into four major sections. Selected commentaries accompany the translation which consist in the main of illuminating quotations from other Egyptian papyri. The aim is to propagate some insight into the gynaecological concepts behind medical practice around 2000 B.C.

Contraceptive Agents↗

CT changes associated with migraine.

In order to determine further the correlation between severe migraine and cerebral atrophy, a group of patients attending either the Charing Cross Hospital migraine clinic or outpatient clinics at the National Hospital, Queen Square, was investigated by computed tomography. The results confirm an association between atrophy and migraine of more than 5 years duration, probably more severe in men than women. The most striking changes were seen in those men who suffered from attacks lasting less than 6 hr.

Adolescent↗

Cord shape and measurements in cervical spondylotic myelopathy and radiculopathy.

A combined clinical myelographic and computed myelographic study was performed in 30 patients with cervical spondylotic myelopathy; computed myelography was also performed in 16 control patients. Good correlation was found between degree of deformity of cross-sectional shapes of the cord and the outcome of surgery, and measurements of anteroposterior diameter and area of the cord seemed helpful in this preliminary study. There was also reasonably good correlation between the clinical features when grouped according to specific tract involvement, and the pattern of deformity shown by the abnormal cross-sectional cord shapes.

Adult↗