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Biomedical subjects

J M Simon

Publications and source records attributed to J M Simon.

At least 73 records · Page 4Linked to original sources
PubMed1987

Labeling index and labeling distribution in the colonic crypts: a contribution to definition of patients at high risk for colorectal cancer.

The labeling index (LI), representing the percentage of S-phase cells, was measured in the healthy colorectal mucosa of subjects without a personal or familial history of neoplasm as well as in persons with a positive history, and was compared to the LI in benign or malignant lesions in a total of 128 subjects. In the healthy mucosa, LI was lowest in control subjects; it rose progressively in patients with a personal history of adenoma, patients with non colorectal cancer, and colorectal cancer patients respectively. There was a significant increase in LI from healthy mucosa to adenoma to carcinoma. The pattern of labeling in the crypts was studied in 56 subjects with different familial and personal histories. Limitation of labeling to the deepest part of the crypts was observed in control subjects and to a lesser extent in the healthy mucosa of patients with adenoma. An upward shift of the proliferative zone was observed in patients with a personal or familial history of cancer; adenomatous lesions had an inverse labeling distribution: labeling decreased from the luminal aspect towards the deep segments. High LI values and a shift of the proliferative zone towards the surface of the crypt may identify individuals at high risk for cancer of the colon and rectum.

Adenoma↗
PubMed1984

[Computed x-ray tomography of abdominal lipoma and liposarcoma in adults. Apropos of 9 cases].

CT scans were performed in 9 patients with fatty tumors of the abdomen: 2 lipomas and 7 liposarcoma. Of primary retroperitoneal origin, five tumors had extended intraperitoneally. Scanning images typical for each type of tumor are described: lipomas are very hypodense and well circumscribed, with thin intratumoral septa; liposarcomas are less hypodense and contain thick septa which may coalesce and form large nodules. Scanner imaging provides precise data on tumor extension and allows early detection of recurrences of these fatty tumors.

Abdominal Neoplasms↗
PubMedDate not supplied

A multidisciplinary approach to chronic pain.

Chronic pain often is frustrating to nurses and patients, since many times it has not been responsive to traditional medical approaches. The purpose of this article is to discuss the chronic pain syndrome and the role of nursing within a multidisciplinary chronic pain rehabilitation program designed to return the patient to a functional lifestyle. The purpose and rationale for each treatment modality within the pain management program is described, although the treatment plans are individualized for every patient. Nurses play a crucial role, because they are the only professionals who are constantly available to the patient. Nurses collect data and continually assess the patient to develop comprehensive nursing care plans. In this intensive educational program, nurses also assist in teaching the patient positive health practices to control the pain. Further evaluations of these chronic pain rehabilitation programs are needed.

Analgesia↗
PubMedDate not supplied

Chronic pain syndrome: nursing assessment and intervention.

Chronic pain is a major health problem in the United States. People with chronic pain syndrome are a subgroup of patients with chronic pain who experience high levels of pain, functional impairment, and depression. Because chronic pain syndrome is a complex multidimensional health problem, nurses must use their expert knowledge and skills in pain management and in rehabilitation nursing to help patients improve their health status and quality of life. This article discusses the nursing assessment and management of chronic pain syndrome as well as an assessment tool that the author has helped develop.

Chronic Disease↗
PubMedDate not supplied

Development of a chronic pain assessment tool.

Research demonstrates that many nurses lack knowledge about pain assessment, the differences between acute and chronic pain, and the use of pain rating scales. In this article, the authors describe an instrument for evaluating chronic pain, the purpose of which is to assess systematically the various dimensions of chronic pain and its impact on quality of life. This assessment can establish a baseline for developing clients' treatment plans and can be used to evaluate the effectiveness of treatment plans. Using this tool can provide an accurate multidimensional assessment of clients' chronic pain experiences. The article also discusses recommendations for other applications of the tool.

Chronic Disease↗
PubMedDate not supplied

Failure of the müllerian regression factor in two patients with complete androgen insensitivity syndrome.

The present paper describes the histological and endocrinologic features of 2 subjects with 46,XY karyotype affected by complete androgen insensitivity syndrome (AIS) with müllerian structures. Both patients had fallopian tubes, but only one had also uterus and presented a seminoma. Serum levels of luteinizing hormone, testosterone and estradiol were high or in the upper part of normal limits, whereas levels of follicle-stimulating hormone were normal. The association between AIS and the presence of müllerian structures observed in these 2 patients might be explained by an impaired synthesis of müllerian regression factor or by a failure in its mechanism of action.

Adolescent↗