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Biomedical subjects

J M Serra

Publications and source records attributed to J M Serra.

36 records · Page 2Linked to original sources

[Bone gammagraphy for evaluating free vascularized bone grafts in mandibular reconstruction].

In oncology jaw reconstruction, the probability of infection, sequestration and failure in scarring is high. For this reason, we use a vascularized free bone graft, whose direct blood flow makes it much more resistant to support the attendant properly. The use of bone scintigraphy by means of three phases acquisition technique is very effective to evaluate the viability of these vascularized grafts during the first days after surgery, in order to adjust the attendant treatments and to prevent the possible complications.

Adult↗

Neurotization of the remaining latissimus dorsi muscle following muscle flap transplant.

The neurotization of the remaining latissimus dorsi muscle at the donor site is a useful technique in children. It is performed during the same surgical procedure as the free vascularized flap and consists of a neurolysis of the thoracodorsal nerve into three to five fascicles, and introducing them into three to five different openings in the muscle fibers. This technique is important in young patients for avoiding functional long-term sequelae such as scoliosis and developmental muscular defects of the vertebral column. Three cases are reported, with evaluation by electromyography and biopsy.

Adolescent↗

The combined composite pectoralis major and minor osteomusculocutaneous flap.

Combining the pectoralis major and minor into a single flap can provide a much longer vascularized segment of bony rib than if the pectoralis major is used alone. This result is possible because of the periosteal vessels emerging from the origins of the pectoralis major and minor. Both muscular attachments are contiguous. The particular characteristics of this flap make it useful for reconstructive surgery of the head and neck when transposed locally, or for other distant regions when microsurgery is attempted.

Bone Transplantation↗

The circumflex scapular flap for reconstruction of mandibulofacial atrophy.

Dissection of the circumflex scapular vessels permits the use of a cutaneous flap of moderate thickness and broad extension because of the plexal arrangement of the two basic arterial components, the cutaneous scapular and the inferior scapular arteries. This flap may be considered as the treatment of choice in reconstructive surgery for facial atrophy of diverse etiology. The anatomic fundamentals and surgical technique for use of this flap are described.

Adolescent↗

Extensive distal subcutaneous metastases of a "benign" giant cell tumor of the radius.

A case of distant metastases of a giant cell tumor of the radius is presented. The tumor within the radius was excised, followed by arthrodesis of the wrist and bone grafting with tibia. At the time she came to us, the patient presented distal dissemination, so we performed curettage of each one of the multiple metastases of soft tissues of the hand. After 9 months, a local recurrence in the radius was resected, and reconstruction was done with a vascularized graft of fibula. Later treatment consisted of intraarterial chemotherapy. The patient is in satisfactory condition 1 year after surgery.

Adult↗

[Rokitansky-Kuster-Hauser-Mayer syndrome. Psychological aspects in current technics in the creation of a neovagina apropos of 2 cases].

A review is made of the actual status of the Rokitansky-Hauser-Kuster-Mayer Syndrome in the following aspects: clinic, diagnostic and actual techniques in the construction of a neovagina. An special remark is made on the importance of the psychologyc and psychosocial aspects in the management, diagnostic and treatment of this patients. Two cases are presented.

Adolescent↗

Extensive intra-hospital spread of a methicillin-resistant staphylococcal clone.

OBJECTIVE: Infection by antibiotic-resistant bacteria can pose serious complications to the therapy of cancer patients. The authors introduced DNA fingerprinting techniques for tracking methicillin-resistant Staphylococcus aureus (MRSA) clones recovered at a central cancer hospital of Lisbon (Instituto Português de Oncologia) with the purpose of making an inventory of the MRSA clones endemic during 1995, and compared them with the outbreak-related clones of 1993. DESIGN: A small group (6 strains) of epidemiologically related MRSA isolated during a suspected outbreak in 1993 and all consecutive single-patient isolates of MRSA (34 strains) recovered between January and November of 1995 from infected patients and health care personnel were characterized using DNA probes and pulsed-field gel electrophoresis. RESULTS: The six 1993 strains and more than half of all 1995 isolates, including those recovered from the health care personnel, showed DNA fingerprints characteristic of the "Iberian MRSA," a multiresistant clone widespread in Portuguese and Spanish hospitals. Four patients were infected by another MRSA clone previously seen only in hospitals in Brazil. CONCLUSION: The epidemic Iberian clone was among the index cases involved with the MRSA outbreak in 1993, and this was found to be endemic in a follow-up survey conducted in 1995, colonizing health care personnel and spreading to most hospital wards. A few isolates of another epidemic clone, the Brazilian MRSA, also were detected among 1995 isolates. A better understanding of the mechanism(s) of epidemicity of these rapidly spreading clones is urgently needed.

Adult↗

Support vector machines for predictive modeling in heterogeneous catalysis: a comprehensive introduction and overfitting investigation based on two real applications.

This works provides an introduction to support vector machines (SVMs) for predictive modeling in heterogeneous catalysis, describing step by step the methodology with a highlighting of the points which make such technique an attractive approach. We first investigate linear SVMs, working in detail through a simple example based on experimental data derived from a study aiming at optimizing olefin epoxidation catalysts applying high-throughput experimentation. This case study has been chosen to underline SVM features in a visual manner because of the few catalytic variables investigated. It is shown how SVMs transform original data into another representation space of higher dimensionality. The concepts of Vapnik-Chervonenkis dimension and structural risk minimization are introduced. The SVM methodology is evaluated with a second catalytic application, that is, light paraffin isomerization. Finally, we discuss why SVMs is a strategic method, as compared to other machine learning techniques, such as neural networks or induction trees, and why emphasis is put on the problem of overfitting.

Alkenes↗

[Comparative study of two methods for laryngeal mask insertion].

OBJECTIVE: To compare two ways of inserting laryngeal airway masks: uninflated and partially inflated to 75% of the volume, as recommended by manufacturers. PATIENTS AND METHOD: We studied 60 ASA I-II patients scheduled for outpatient surgery under general anesthesia with numbers 3 or 4 laryngeal masks, after having obtained informed consent from the patients (or parents in the case of minors). The patients were randomly assigned to two groups. In group A the masks were inserted inflated to 75% of volume as recommended by manufacturers, whereas in group B deflated masks were inserted as described by Brain. Anesthesia was standardized for all patients. One patient was withdrawn from the study when a technical error was detected. We recorded the presence of criteria predictive of difficult airway management, systolic and diastolic blood pressures, heart rate at four times (baseline, before and after induction and after insertion of the mask), number of insertion tries, final mask volume needed for adequate ventilation, need for an additional dose of the hypnotic drug and complications. RESULTS: No statistically significant differences between the two insertion methods were found. Difficult airway management criteria were unrelated to difficulty of mask insertion. Correct insertion of an uninflated mask proved impossible in one patient, in whom we were then able to insert an inflated mask. CONCLUSION: No differences were found between inflated insertion and Brain's uninflated insertion technique. We believe that inflated mask insertion might be useful when uninflated insertion proves impossible.

Adult↗

[Transplantation of free vascularized jejunum for esophageal reconstruction].

Two cases of pharyngo-esophageal carcinoma treated with tumor resection followed by insertion of a vascularized jejunal free graft using microsurgical technique in order to maintain esophageal contiguity are presented. Both cases have received pre-operative radiotherapy. This presentation is motivated by the excellent results obtained in this palliative treatment of said type of cancer. The jejunal transplant improves the quality of life of these patients with less morbidity and mortality compared with other methods of esophageal reconstruction.

Aged↗

[Surgical treatment of eyelid tumors].

Our surgical protocol for reconstruction of eyelid's defects after tumor excision is presented. Each technique is applied depending on the site and extension of the lesion and also on the pathologic characteristics of the tumor.

Eyelid Neoplasms↗