Dystrophy, abiotrophy, amyotrophy.
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Muscles↗
Biomedical subjects
J M S Pearce
Publications and source records attributed to J M S Pearce.
Restless leg syndrome.
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History, 17th Century↗
Romberg and his sign.
Moritz Heinrich Romberg (1795-1873) acquired much of the wisdom and attitudes prevailing in English medicine when in 1820 he translated into German, Andrew Marshall's (1742-1813) The Morbid Anatomy of the Brain and Charles Bell's The Nervous System of the Human Body. He revolutionised European neurology, publishing his Lehrbuch der Nervenkrankheiten des Menschen: the first systematic textbook in neurology. Romberg's contribution to neurology, and his establishing tabes dorsalis as a distinctive disease were of crucial importance. Romberg's sign, once synonymous with tabes dorsalis, became recognised as common to all proprioceptive disorders of the legs. His several major clinical contributions included: a classic description of achondroplasia, progressive facial hemiatrophy, and an unmistakable description of the pupils in tertiary syphilis before E.J. Remak and Argyll Robertson.
History, 18th Century↗
A note on bent spines: 'camptocormia' and 'head ptosis'.
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History, 20th Century↗
Paraneoplastic limbic encephalitis.
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Diagnosis, Differential↗
Mary Broadfoot Walker (1888-1974): a historic discovery in myasthenia gravis.
As a clinical entity, myasthenia gravis was not recognized until Samuel Wilks in 1877 described bulbar and peripheral muscular weakness. In the Lancet of June 2, 1934, the remarkable discovery of physostigmine treatment by Dr. Mary Walker was published, which was to become the mainstay of symptomatic treatment. A quiet and modest physician, she laboured with considerable success under many obstacles in her work and career.
Cholinesterase Inhibitors↗
Chronic regional pain and chronic pain syndromes.
This paper seeks to consider the validity and utility of two related terms in spinal and other injuries: complex regional pain syndrome (CRPS) and chronic pain syndrome (CPS). It is argued that the words chronic regional pain syndrome convey neither understanding of the condition nor of its mechanism. They simply redefine the clinical problem, but fail to establish specific diagnostic features or consistent primary pathogenesis. CRPS is best construed as a reaction to injury, or to excessive, often iatrogenic, immobilization after injury; but it is not an independent disease. The diagnosis of CPS groups together ill-defined symptoms under a convenient, but medically untestable and therefore inept label. Patients, lawyers, and support groups commonly deny psychogenesis, with the sadly mistaken notion that this implies a bogus or spurious cause.
Chronic Disease↗
Neuromyelitis optica.
The combination of optic neuritis and myelitis, the so-called Neuromyelitis optica is an uncommon pattern of demyelinating disorder. In 1870, Sir Thomas Clifford Allbutt first reported the association and Erb published a comparable report. Gowers and Dreschfeld described other instances in the 19th century. This paper attempts to review the syndrome to consider whether it merits recognition as a disease, sui generis, or rather as a syndrome symptomatic of multiple sclerosis, acute disseminated encephalomyelitis, and other immunological disorders. Two forms are distinguished: a monophasic illness, and a relapsing form. The claimed differential features separating it from classical multiple sclerosis are appraised. Modern immunology suggests an antibody-dependent, complement-mediated pathogenesis.
Humans↗
Poliomyelitis (Heine-Medin disease).
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History, 19th Century↗
Brodmann's cortical maps.
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Brain Mapping↗
Historical note. Neuralgic amyotrophy.
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Brachial Plexus Neuritis↗