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Biomedical subjects

J M Ryan

Publications and source records attributed to J M Ryan.

143 records · Page 8Linked to original sources

WHO collaborative study on the sero-epidemiology of rubella.

Under the auspices of WHO an investigation was made by 9 laboratories in different parts of the world on the distribution of rubella antibodies in girls and women of child-bearing age. In the first part of the study the objective was to determine the reliability and reproducibility of the tests employed. It was found that there were no significant differences in the variability of the titres obtained in different laboratories when the results were compared with those obtained by repeatedly testing the same sera in one laboratory.In the second part of the study sera were obtained from girls in schools and women attending clinics and health centres. They were not taken from random samples of the populations. In most of the studies the pattern of development of antibody was similar. About half the persons had antibody at 6-8 years of age and 80%-87% at 17-22 years of age, the percentage remaining relatively constant thereafter. The island populations of Trinidad and Jamaica and a rural area of Japan were, however, found to have significantly fewer women with antibodies than urban areas in Europe or the Americas.

Adolescent↗

Child abuse and the community health nurse.

Little attention has been given to prevention in the area of child abuse--the victims are almost always discovered after the fact. Yet several observable factors within a family situation can identify the family at high risk for child abuse, and permit intervention by the community nurse before the risk becomes reality.

Adult↗

Finite element based predictions of preferred material symmetries in saccular aneurysms.

Over the years, various hypotheses have implicated the role of structural instabilities in the expansion of intracranial saccular aneurysms. Recent nonlinear analyses suggest, however, that particular subclasses of aneurysms are structurally stable (in the mechanics sense) and that we must consider different hypotheses. Indeed, based on an ever-increasing database, it appears that aneurysms may well expand via the remodeling of their constituents. Although more data and a kinetics-based formulation of remodeling are needed to examine this hypothesis, we present results from quasistatic finite element analyses of 12 subclasses of lesions that support the remodeling hypothesis. Briefly, we identify regional variations in material symmetry, for a class of noncomplicated axisymmetric lesions subjected to a uniform distension pressure, that minimize local maxima in multiaxial stress and tend to homogenize the stress field. Such symmetries are termed preferred. It is shown that the numerical predictions are consistent with the teleological concept that some intracranial saccular aneurysms will seek to become spherical, since the sphere is an optimal geometry for resisting a distension pressure. To achieve this, however, different subclasses must develop differently. Lesions having an initially large neck:height ratio must increase in height and therefore may seek to become increasingly stiffer circumferentially from the fundus to the neck. Conversely, lesions having an initially small neck:height ratio must increase in breadth and therefore may seek to become increasingly stiffer meridionally from the fundus to the neck. We submit that these results demonstrate the need for a detailed histological examination of regional variations in collagen organization in human lesions, for it is upon data that an analysis of remodeling must be founded.

Anisotropy↗

Reiter's aortitis with pericardial fluid, heart block and neurologic manifestations.

A man who presented with Reiter's triad and keratoderma blenorrhagicum followed by cardiac manifestations is reported. He developed mild aortic insufficiency, A-V block and pericardial effusion. Painful ophthalmoplegia occurred 5 months later with exacerbation of the cardiac complications as corticosteroids were being tapered. Retreatment with high dose corticosteroids resulted in a remarkable remission of the neurologic complications and stabilization of his cardiac manifestations now maintained for 3 years.

Adrenal Cortex Hormones↗

Review of a mobile accident and emergency unit at a rock concert.

On Saturday 16th May 1992, an outdoor Rock concert was held at a rural location located between two hospitals which are fourteen miles apart. It was attended by over 50,000 people. A mobile accident and emergency unit (MAEU), was staffed by two doctors and five nurses. The facilities, demands and injury pattern are reviewed, and recommendations for future events are made.

Alcoholic Intoxication↗