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Biomedical subjects

J M Rothberg

Publications and source records attributed to J M Rothberg.

46 records · Page 3Linked to original sources
PubMed1978

A longitudinal study of military performance subsequent to civilian drug use.

This study evaluates the military performance of soldiers who were identified by the Army's urine screening program as having used drugs at the time they reported for active duty. The study used prospectively defined cohorts of large size (over 1,600 urinalysis positive and over 2,400 urinalysis negative entering males) and used longitudinal outcome measures drawn from existing medical and personnel files. The major findings are that the urinalysis positive individuals were significantly more likely not to complete their tour of duty, were more likely to be hospitalized, and had more bed-days per hospitalization than their urinalysis negative fellow soldiers. In terms of cohorts entering the Army, however, minimal improvement in outcome was found by considering an entirely drug-free cohort (obtained by omitting the urinalysis positive individuals) compared to a random cohort which contained positives at the then current prevalence of 2 per cent.

Humans↗
PubMed1976

An application of stepwise discriminant analysis to the characterization of military heroin dependents, illicit drug users, and psychiatric patients.

This application of stepwise discriminant analysis explores a way to structure skewed-sample interview data, discusses some implications of the results and the conceptual limitations of assumptions about deviancy, and suggests a focus for future studies of the complex phenomena of drug abuse. The methodology differs from previous reports in that it uses a constant probability level, letting the computational procedure determine the number of significant variables. It also provides a method of determining the "chance" level (the amount of correct classification when there are no differences between the groups) so that the observed correct classification values may be usefully interpreted.

Computers↗
PubMed1975

Addicted and nonaddicted drug users. A comparison of drug usage patterns.

Adetailed analysis of drug usage patterns of 101 multidrug-using soldiers disclosed little differentiation between individuals with a history of heroin addiction (N=68) from demographically similar multidrug-using (but nonaddicted) peers (N=33). Prior to the onset of herion addiction, relatively few differences in drug usage patterns emerged between the two groups, and what differences there were indicated more extensive drug use and a more rapid progression of drug use among the nonaddicted users. A "stepping-stone hypothesis" of heroin addiction is refuted by these data. Differences in drug use emerge after the intiation of heroin. Within a few months after first heroin use, those who did not become addicted returned to their preheroin experimentation levels of drug taking while the addicted group maintained an escalating pattern of opiate use.

Adolescent↗
PubMedDate not supplied

Implications of oncogenomics for cancer research and clinical oncology.

The explosion of information generated by large-scale functional genomics technologies has resulted in an exponential increase in the number of potential genes and proteins available for pharmaceutical and diagnostic research development. In order to tap this potential, the primary challenge is to develop a strategy to effectively integrate and extract meaning from the human genomic sequence information that has been generated since the start of the Human Genome Project. This article deals with the strategies being applied by academics and by the biotechnology sector to sort and triage this information with the ultimate goal of identifying future therapeutic targets for cancer and other diseases.

Animals↗