Biomedical subjects
Publications and source records attributed to J M Provenzale.
Contrast angiography is the standard means of diagnosing spinal dural arteriovenous fistulas. We present a patient in whom a spinal dural arteriovenous fistula was demonstrated on phase contrast MR angiography.
Pituitary apoplexy almost invariably occurs following hemorrhage into a pituitary neoplasm. We report a case in which pituitary apoplexy occurred in the setting of, and probably secondary to, dissection of the internal carotid artery.
We report development of an intracranial epidermoid cyst 2 years after a depressed skull fracture. The epidermoid cyst is presumed to be the result of introduction of epidermal elements at the time of trauma. Post-traumatic intracranial epidermoid cysts are rare and appear to be less common than those occurring in the spine.
OBJECTIVE: Our goal was to demonstrate the spectrum of neuroradiologic (CT, MR, and angiographic) findings in craniocervical arterial dissection (CAD) related to exercise or sporting activities and compare the diagnostic utility of CT, MRI, and MR angiography (MRA). MATERIALS AND METHODS: The neuroradiologic examinations of 11 patients with CAD was performed: CT was performed in 10 patients, cranial MRI in 9, cranial and cervical MRA in 4, and contrast angiography in 10. The CT examinations were assessed for the presence of an infarction or a hyperdense artery (consistent with intraluminal thrombus), MRI examinations for the presence of infarction or abnormal periarterial signal, and contrast angiograms for arterial stenosis or occlusion, luminal irregularity, pseudoaneurysm, intimal flap, or distal branch occlusions. RESULTS: Computed tomography demonstrated infarction in four patients. At contrast angiography, a dissection was found in the artery supplying the region of infarction in all cases. A hyperdense artery was found by CT in two patients, which correlated with dissection of the artery or its parent artery on contrast angiography. Cranial MRI findings were seen in six patients (infarction in five, periarterial signal abnormality in five). Dissection was confirmed in all four patients with abnormal periarterial signal who underwent contrast angiography. Two patients with abnormal intracranial periarterial signal had corresponding abnormalities on MRA. False-negative cranial and cervical MRI and MRA studies were performed in one patient because the imaging volumes used for the cervical and intracranial MR examinations did not overlap. Four patients with normal intracranial arterial signal had dissection in the neck demonstrated by contrast angiography. CONCLUSION: Neuroradiologic findings of CAD can include infarction, a hyperdense artery on CT, abnormal periarterial signal on MRI, and a narrowed arterial signal column on MRA. Computed tomography is an insensitive screening examination. Proper use of MRI and MRA involves examination of both the head and the neck with overlapping imaging volumes of the two regions.
OBJECTIVE: Our goal was to characterize the CT and MR features of supratentorial ependymomas and subependymomas. MATERIALS AND METHODS: The CT or MRI examinations of 11 supratentorial ependymomas (average patient age: 16 years) and 3 supratentorial subependymomas (average age: 60 years) were analyzed for tumor size, location, and appearance. RESULTS: Ependymomas were periventricular (nine), intraventricular (one), or both (one) and averaged 4 cm in diameter. Four of nine ependymomas examined by CT were calcified. Eight ependymomas had a cystic component. All seven ependymomas evaluated with MRI demonstrated prolonged T1 and T2 relaxation, with two having foci thought to represent intratumoral hemorrhage. The MR contrast enhancement patterns included an enhancing nodule within the wall of a cyst (four), heterogeneous enhancement of cystic/solid lesions (two), and homogeneous enhancement of a solid lesion (one). All subependymomas were solid intraventricular masses, averaging 2.6 cm in diameter. One had small amounts of calcification, and none were cystic. All three were isointense or hypointense to white matter on T1-weighted MR images and heterogeneous or hyperintense on T2-weighted images, with variable enhancement characteristics. Early (< 1 year) postsurgical recurrence was seen in two ependymomas and one subependymoma. CONCLUSION: Supratentorial ependymomas are typically large, cystic, calcified, extraventricular masses found in children and young adults. Supratentorial subependymomas are generally solid, intraventricular masses that are usually smaller than ependymomas and occur in an order patient population.
OBJECTIVE: The purpose of this study was to determine if typical clinical and neuroradiologic patterns exist in patients with spontaneous vertebral artery (VA) dissection. MATERIALS AND METHODS: The medical records and neuroradiologic examinations of 14 patients with spontaneous VA dissection were reviewed. The medical records were examined to exclude patients with a history of trauma and to record evidence of a nontraumatic precipitating event ("trivial trauma") and presence of possible risk factors such as hypertension. All patients underwent conventional angiography, 13 either CT or MRI (11 both CT and MRI), and 3 MRA. Conventional arteriograms were evaluated for dissection site, evidence of fibromuscular dysplasia, luminal stenosis or occlusion, and pseudoaneurysm formation. CT examinations for the presence of infarction or subarachnoid hemorrhage. MR examinations for the presence of infarction or arterial signal abnormality, and MR angiograms for abnormality of the arterial signal column. RESULTS: Seven patients had precipitating events within 24 h of onset of symptoms that may have been causative of dissection and five had hypertension. At catheter angiography, two patients had dissections in two arteries (both VAs in one patient, VA and internal carotid artery in one patient), giving a total of 15 VAs with dissection. Dissection sites included V1 in four patients, V2 in one patient, V3 in three patients, V4 in six patients, and both V3 and V4 in one patient. Luminal stenosis was present in 13 VAs, occlusion in 2, pseudoaneurysm in 1, and evidence of fibromuscular dysplasia in 1. Posterior circulation infarcts were found on CT or MR in five patients. Subarachnoid hemorrhage was found on CT in two patients and by lumbar puncture alone in two patients. Abnormal periarterial signal on MRI was seen in three patients. MRA demonstrated absent VA signal in one patient, pseudoaneurysm in one, and a false-negative examination in one. Repeat catheter angiography of nine VAs at an interval ranging from 2 weeks to 1 year showed progression to occlusion in two arteries, unchanged appearance in 4, and angiographic resolution in three, which did not closely correlate with clinical outcome. CONCLUSION: No preferred site of dissection along the course of the VA was found in this study. CT and MR examinations of the head are frequently normal in patients with VA dissections. No correlation between clinical outcome and findings at repeat angiography was demonstrated.
PURPOSE: Our aim was to determine the thoracic manifestations of patients with antiphospholipid antibodies (APAs). METHOD: We performed a retrospective review of the clinical records and thoracic imaging studies of 88 patients (63 women, 25 men; mean age 47 years) with APAs to determine the spectrum of thoracic disease. RESULTS: Nine patients (10%) had thoracic abnormalities, including eight with pulmonary embolism (PE) and one with aortic thrombus. One patient with PE had subclavian vein thrombosis. Coexistent thromboses included deep venous thrombosis of the leg in six patients. CONCLUSION: PE was the most common thoracic abnormality in our patients. The presence of these antibodies should be suspected in patients with PE of otherwise unexplained etiology.
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BACKGROUND AND PURPOSE: Our purpose was to compare diffusion tensor MR and magnetization transfer imaging in assessing normal-appearing white matter (WM) regions in multiple sclerosis (MS). METHODS: Diffusion tensor, magnetization transfer, and conventional MR imaging were performed in 12 patients with MS. Fractional anisotropy, apparent diffusion coefficients (ADCs), and magnetization transfer ratios (MTRs) were measured in plaques, normal-appearing periplaque WM (PWM) regions, and normal-appearing WM regions remote from plaques. Mean fractional anisotropy, ADCs, and MTRs were calculated and compared in WM regions. RESULTS: Fractional anisotropy was lower in normal-appearing PWM regions than in remote WM regions (P <.001) but higher than in plaques (P <.001). MTRs were lower (not significantly, P =.19) in normal-appearing PWM regions than in remote regions. MTRs were higher in normal-appearing PWM regions than in plaques (P <.001). ADCs were higher in normal-appearing PWM regions than in remote regions (P =.008) but lower than in plaques (P =.001). Correlation between fractional anisotropy and MTRs of individual lesions was poor (r = 0.18) and between fractional anisotropy and ADC, modest (r = -0.39). CONCLUSION: In MS, diffusion tensor MR imaging can depict differences between WM regions that are not apparent on conventional MR images. Anisotropy measurements may be more sensitive than those of MTRs in detecting subtle abnormalities in PWM.
OBJECTIVE: Our aim was to determine the frequency with which a lesion responsible for hemiballismus was detectable on CT and MR examinations. MATERIALS AND METHODS: The CT and MR examinations of six patients with hemiballismus were reviewed. Three patients underwent MRI alone, two CT alone, and one underwent both CT and MRI. Sites considered as possible locations for a lesion causing hemiballismus included the subthalamic nucleus on the side contralateral to the movements, contralateral putamen, caudate nucleus, thalamus, corpus striatum, lenticular nucleus, substantia nigra, and the premotor and motor cortex. RESULTS: A lesion likely to account for hemiballismus was found in five patients (contralateral subthalamic nucleus in four patients, contralateral putamen in one patient). Causes of hemiballismus included infarction (one patient), hemorrhage (two patients), trauma (one patient), and an abscess (one patient). A responsible lesion was detected in all five patients who underwent MRI. In one patient who underwent CT alone, a responsible lesion was not identified. CONCLUSION: A lesion responsible for hemiballistic movements can generally be found on cross-sectional imaging examinations. Because the multiplanar imaging capability of MR appears to allow for sensitive detection of even small lesions in sites likely to cause hemiballismus, MRI offers the best means of imaging these patients.
PURPOSE: To demonstrate the neuroradiologic findings in patients with polyarteritis nodosa. METHODS: A review of hospital records for a 10-year period revealed 50 patients with a discharge diagnosis of polyarteritis nodosa. Thirteen patients had undergone neuroimaging, and abnormal findings were found in 5 cases; these were the subjects of this study. RESULTS: All 5 patients had abnormal findings on CT scans, 3 had abnormal findings on MR images, and 1 had an abnormal finding on a cerebral angiogram. All patients had cerebral cortical or subcortical infarctions, and 1 also had small infarctions within the brain stem and cerebellum. One patient had cerebral angiographic findings of arteritis. The diagnosis of arteritis was considered probable or possible in 3 other patients. Three patients had echocardiographic evidence of concentric hypertrophy and a hypocontractile left ventricle resulting from polyarteritis nodosa-related hypertension. Cardiogenic embolism was considered the likely cause in 1 patient. CONCLUSION: Small peripheral cerebral infarctions, consistent with an arteritis involving medium-sized and small arteries, were the most common finding. However, cardiogenic embolism should also be considered as a possible cause of cerebral infarction in patients with polyarteritis nodosa who have left ventricular dysfunction.