Search PubMed⌕ Search

Biomedical subjects

J M Pearson

Publications and source records attributed to J M Pearson.

At least 91 records · Page 5Linked to original sources
PubMed1970

Experimental and clinical studies on rifampicin in treatment of leprosy.

Rifampicin showed high activity against experimental leprosy, inhibiting the multiplication of dapsone-sensitive and dapsone-resistant strains of Mycobacterium leprae in mice fed 5 mg./kg. body weight. In a formal pilot-type trial on six previously untreated patients with active lepromatous leprosy, rifampicin (600 mg. daily by mouth) was as effective as standard treatment with dapsone. Myco. leprae, however, appeared to be killed more rapidly by rifampicin than by dapsone or other antileprosy drugs so far studied. This was confirmed on a further 10 patients, including two with dapsone resistance, and from the infectivity in mice of bacilli recovered from patients during treatment with rifampicin or dapsone. These results are consistent with the bactericidal activity of rifampicin against other micro-organisms, which could be important to the chemotherapy of leprosy, since all antileprosy drugs in current use are bacteriostatic.

Animals↗
PubMed1969

Human leprosy in normal mice.

It has now been shown that normal mice can be used as models for studying the early stages in the development of leprosy. Inoculation into the foot pads of mice of as few as 10(4) leprosy bacilli leads to infections which spread to distant sites via the blood stream and after two or more years give rise to granulomata and neural damage at the sites of inoculation. Where the tissue response had fully developed it reproduced exactly the histological features of human leprosy in the borderline range.

Animals↗
PubMedDate not supplied

A light microscopical, immunohistochemical, and ultrastructural comparison of hemangiomata and lymphangiomata.

In this study we have compared the light microscopical, immunohistochemical, and ultrastructural features of five hemangiomata of the dermis with five lymphangiomata of the dermis and subcutaneous tissue. We have attempted to define differentiating features with regard to the ultrastructural appearances and the immunohistochemical staining for the endothelial markers factor VIII-related antigen (FVIII:RAg) and Ulex europaeus agglutinin I (UEA-I). In addition, immunolocalization of FVIII:RAg at the ultrastructural level was performed to compare its distribution within endothelial cells of neoplastic blood vessels and lymphatic vessels. The results show that immunohistochemical staining for FVIII:RAg and UEA-I does not differentiate between blood and lymphatic vessels. However, the presence of a fragmented basal lamina and anchoring filaments does distinguish lymphatic vessels from blood vessels ultrastructurally.

Adolescent↗
PubMedDate not supplied

Flow cytometric DNA characteristics of radiation colitis--a preliminary study.

The DNA status of 12 rectal biopsies, taken during the investigation of radiation proctitis, was investigated. Of these six were in the acute phase and six in the chronic phase. All of the acute biopsies had diploid DNA, despite bizarre histological epithelial cell appearances. Two of the chronic phase biopsies were to have aneuploid DNA profiles. This finding may be relevant to the increased risk of malignancy in irradiated tissues.

Acute Disease↗