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Biomedical subjects

J M Pearce

Publications and source records attributed to J M Pearce.

At least 253 records · Page 14Linked to original sources
PubMed1983

The present place of routine ultrasound screening.

The value of routine ultrasound examinations is illustrated in Table 3. Ultrasound examination may of course be indicated in early pregnancy on clinical grounds. If it is not, we recommend that all patients should have measurement of the BPD between 16 to 18 weeks' gestation even if they have optimal menstrual histories. It is preferable to have a routine ultrasound service if a MSAFP programme is offered because, although it is possible to scan only patients with a raised MSAFP, prior knowledge of gestational age helps in the timing of the sample and prevents concern in patients with inaccurate dates. At 16 to 18 weeks' gestation multiple pregnancies can be diagnosed reliably and many structural abnormalities can be detected even when the routine examination is performed by non-medically trained personnel. A fundal placenta at 16 to 18 weeks' gestation excludes the possibility of placenta praevia. Seeing the fetus on the ultrasound screen and watching fetal movements strengthens parental feelings towards pregnancy. A repeat ultrasound examination in the third trimester to measure AC is superior to clinical means of detecting growth retardation. Placental localization at this gestation is accurate and has removed the need for the hazardous 'examination under anaesthetic'. If facilities are available we recommend that every patient has a repeat scan in the third trimester. If facilities are insufficient then we recommend that high risk patients have serial scans and that other patients have SFH measurement at each antenatal visit, and that only those that have a low SFH should have repeat ultrasound examinations. Until the day arrives when there is sufficiently trained personnel, adequate equipment and time to perform detailed examinations of all fetuses at 16 to 18 weeks' gestation, together with serial examination and measurement of all growth parameters, we feel the above schema makes the best use of available facilities.

Female↗
PubMed1981

Scapuloperoneal syndrome with cardiomyopathy: report of a family with autosomal dominant inheritance and unusual features.

Four members of a family with scapuloperoneal syndrome were examined and investigated. The pattern of inheritance was autosomal dominant and the myopathic basis of the muscle atrophy was established by histological studies of muscle and spinal cord. The family illustrates an unusual combination of features which appear to be distinct from those of other families with myopathic scapuloperoneal syndrome and autosomal dominant inheritance. These include early age of onset and rapid progression in most cases; occurrence of early muscle contractures; and a high incidence of severe cardiomyopathy in three of the four cases. Some of these features resemble those seen in the x-linked form of the disease and the present family appeared to be a new variant of the autosomal dominant form of the scapuloperoneal syndrome.

Adult↗
PubMed1980

Chronic migrainous neuralgia: a variant of cluster headache.

A series of 101 patients suffering from cluster headache is examined in this paper. Ninety-five of these patients suffered from the periodic form of the disorder and in clinical symptomatology differed little from the many previous reports in the literature. As in other series, the condition was seldom diagnosed when the patient presented to the clinic. Six patients had a different pattern. In these there was no brief cluster, but rather a continuous period of once- or twice-daily attacks of migrainous neuralgia without apparent spontaneous remission. Both primary and secondary types of chronic migrainous neuralgia are recognized: in the latter instance attacks which were at first periodic later changed to the continuous or chronic form. In these patients the attacks were less responsive to ergotamine and methysergide than are patients with the periodic cluster headache, although individually useful periods of control of symptoms were obtained with these drugs. The use of lithium in three patients provided continuous control when the drug was used in low dosage, and no side-effects were observed.

Adolescent↗
PubMed1980

Lack of effect of interview and gynaecological examination on plasma levels of prolactin and cortisol.

Levels of prolactin and cortisol were measured in plasma from 18 non-pregnant patients attending a general gynaecological outpatient clinic for the first time. Each patient was seen by one of two clinicians and blood samples were taken at six different stages of the clinical interview and examination. No significant changes in the levels of prolactin or cortisol were observed suggesting that pulsatile secretion and the response to the stress of an outpatient gynaecological visit are not important factors in the interpretation of plasma prolactin levels.

Female↗